How Can Next-Generation Sequencing (Genomics) Help Us in Treating Colorectal Cancer? [0.03%]
下一代测序（基因组学）如何帮助我们治疗结直肠癌？
Kristen K Ciombor,Sigurdis Haraldsdottir,Richard M Goldberg
Kristen K Ciombor
Next generation sequencing methods have exponentially increased the amount of genomic information available to scientists and clinicians. This review will explain the evolution of tumor gene sequencing and identify its potential to accelera...
Prognostic Impact of Deficient DNA Mismatch Repair and Mutations in KRAS, and BRAFV600E in Patients with Lymph Node-Positive Colon Cancer [0.03%]
DNA错配修复缺陷及KRAS突变和BRAF V600E突变在淋巴结阳性结肠癌患者中的预后价值
Aziz Zaanan,Jean-Baptiste Bachet,Thierry André et al.
Aziz Zaanan et al.
While tumor stage remains the key determinant of colorectal cancer (CRC) prognosis and treatment, there is considerable stage-independent variability in clinical outcome. Molecular markers hold promise for explaining variations in clinical ...
Vitamin D for Prevention and Treatment of Colorectal Cancer: What is the Evidence? [0.03%]
维生素D预防和治疗结直肠癌的证据有哪些？
Kimmie Ng
Kimmie Ng
Vitamin D insufficiency is highly prevalent in the U.S., particularly among colorectal cancer (CRC) patients. These low levels of vitamin D are concerning in light of increasing evidence that vitamin D may have health benefits beyond skelet...
Pulmonary Metastasectomy for Colorectal Cancer: Recent Reports Prompt a Review of the Available Evidence [0.03%]
结直肠癌肺转移手术治疗：近期报道促使重新评估现有证据
Tom Treasure
Tom Treasure
Pulmonary metastasectomy for colorectal cancer is commonplace surgery, but the practice has grown on the basis of follow-up studies. These studies base their conclusion on the effectiveness of metastasectomy on the survival rates at 5 years...
Lukasz Durko,Ewa Malecka-Panas
Lukasz Durko
Many studies suggest that Western lifestyle and dietary factors may be responsible for the high incidence of colorectal cancer in industrialized countries. Consumption of high amounts of red and processed meat and low intake of fiber and mu...
Shahid Umar
Shahid Umar
Gut flora generally contributes to a healthy environment while both commensal and pathogenic bacteria that influence the innate and adaptive immune responses, can cause acute and/or chronic mucosal inflammation. Citrobacter rodentium (C. ro...
Zhiyun He,Dharmalingam Subramaniam,Zhongtao Zhang et al.
Zhiyun He et al.
Radioresistance is a frustrating obstacle for patients with colorectal cancers (CRCs) undergoing radiotherapy. There is an urgent need to find an effective agent to increase the sensitivity of CRCs to radiation. Honokiol, an active compound...
Lin Zhang,Jian Yu
Lin Zhang
Deregulation of apoptosis is a hallmark of human cancer and contributes to therapeutic resistance. Recent advances in cancer genomics reveal a myriad of alterations in key pathways that directly or indirectly increase tumor cell survival. T...
The IDEA (International Duration Evaluation of Adjuvant Chemotherapy) Collaboration: Prospective Combined Analysis of Phase III Trials Investigating Duration of Adjuvant Therapy with the FOLFOX (FOLFOX4 or Modified FOLFOX6) or XELOX (3 versus 6 months) Regimen for Patients with Stage III Colon Cancer: Trial Design and Current Status [0.03%]
国际学界（IDEA）协作组：FLORFX(FLORFX4或改良FLORFX6)和XELOX（3个月与6个月）辅助化疗方案治疗Ⅲ期结肠癌患者的三期临床试验的前瞻性合并分析：研究设计及现状
Thierry André,Timothy Iveson,Roberto Labianca et al.
Thierry André et al.
The International Duration Evaluation of Adjuvant Chemotherapy (IDEA) collaboration was established to prospectively combine and analyze data from several randomized trials conducted around the world to answer whether a three-month course o...
The RNA-Binding Protein Musashi1: A Major Player in Intestinal Epithelium Renewal and Colon Cancer Development [0.03%]
RNA结合蛋白Musashi1在肠道上皮更新及结肠癌发生发展中的作用研究
Michelina Plateroti,Patricia Rosa de Araujo,Acarizia Eduardo da Silva et al.
Michelina Plateroti et al.
Aberrant gene expression is the cause and the consequence of tumorigenesis. A major component of gene expression is translation regulation; a process whose main players are RNA-binding-proteins (RBPs). More than 800 RBPs have been identifie...