Neoadjuvant Rectal (NAR) Score: a New Surrogate Endpoint in Rectal Cancer Clinical Trials [0.03%]
新辅助治疗直肠癌临床试验的替代终点——NAR评分
Thomas J George Jr,Carmen J Allegra,Greg Yothers
Thomas J George Jr
The conduct of clinical trials in colorectal cancer has historically relied upon endpoints such as disease-free (DFS) or overall survival (OS). While ideal, these endpoints require long-term follow-up, thus contributing to a slow pace of sc...
The Increasing Relevance of Tumour Histology in Determining Oncological Outcomes in Colorectal Cancer [0.03%]
结直肠癌中肿瘤组织学在决定肿瘤结局中的作用越来越重要
Iris D Nagtegaal,Niek Hugen
Iris D Nagtegaal
Colorectal cancer is not just one type of cancer. Differences in outcome and reaction to treatment can at least be partly explained by different histological and molecular subtypes. Recognition of these differences may influence treatment d...
Biomarkers of Inflammation and Immune Function and Risk of Colorectal Cancer [0.03%]
炎症和免疫功能生物标志物与结直肠癌风险的关系
Alicia Garcia-Anguita,Artemisia Kakourou,Konstantinos K Tsilidis
Alicia Garcia-Anguita
A substantial number of prospective epidemiological studies have been conducted to investigate the association between biomarkers of inflammation and immune function and risk of colorectal cancer. Although pre-diagnostic concentrations of t...
D Kim Turgeon,Dean E Brenner
D Kim Turgeon
Human DNA fragments, as well a as whole colonocytes, can be found in stool and interrogated for mutations associated with carcinogenesis. Multiplexed panels of point mutations in fecal DNA improved the sensitivity of cancer detection (51.6%...
What Are the Best Questionnaires To Capture Anorectal Function After Surgery in Rectal Cancer? [0.03%]
评估直肠癌手术后肛门直肠功能的最佳问卷有哪些？
Tina Yen-Ting Chen,Katrine J Emmertsen,Søren Laurberg
Tina Yen-Ting Chen
With enhanced surgical techniques and neoadjuvant therapy in rectal cancer, survivorship issues are at the forefront of clinical practice and research. More and more patients are living with altered bowel habits following rectal cancer surg...
Sandeep Sreevalsan,Stephen Safe
Sandeep Sreevalsan
Several agents used for treatment of colon and other cancers induce reactive oxygen species (ROS) and this plays an important role in their anticancer activities. In addition to the well-known proapoptotic effects of ROS inducers, these com...
Hassan Ashktorab,Hassan Brim
Hassan Ashktorab
Colorectal cancer (CRC) is one of the major cancers in the world and second death-causing cancer in the US. CRC development involves genetic and epigenetic alterations. Changes in DNA methylation status are believed to be involved at differ...
Santanu Paul,Satish Ramalingam,Dharmalingam Subramaniam et al.
Santanu Paul et al.
Cell growth and proliferation are controlled through different posttranslational modifications including demethylation, a process regulated by regulated by the demethylase enzymes. This review focuses on our current understanding of functio...
Mechanisms by Which Pleiotropic Amphiphilic n- 3 PUFA Reduce Colon Cancer Risk [0.03%]
长链n-3多不饱和脂肪酸减少结肠癌风险的多效性分子机制研究进展
Robert S Chapkin,Vanessa DeClercq,Eunjoo Kim et al.
Robert S Chapkin et al.
Colorectal cancer is one of the major causes of cancer-related mortality in both men and women worldwide. Genetic susceptibility and diet are primary determinants of cancer risk and tumor behavior. Experimental, epidemiological, and clinica...
Suman Suman,Trinath P Das,Murali K Ankem et al.
Suman Suman et al.
The activation of Notch signaling is implicated in tumorigenesis in the colon due to the induction of pro-survival signaling in colonic epithelial cells. Chemoresistance is a major obstacle for treatment and for the complete eradication of ...