Ibrahim Nassour,Patricio M Polanco
Ibrahim Nassour
Minimally invasive surgery has been cautiously introduced in surgical oncology over the last two decades due to a concern of compromised oncological outcomes. Recently, it has been adopted in liver surgery for colorectal metastases. Colorec...
Kristen K Ciombor,Richard M Goldberg
Kristen K Ciombor
Angiogenesis is a complex biologic process critical to growth and proliferation of colorectal cancer. The safety and efficacy of various anti-angiogenic agents have been investigated in many treatment settings. Bevacizumab, an anti-vascular...
Circulating Tumor Cells Versus Circulating Tumor DNA in Colorectal Cancer: Pros and Cons [0.03%]
循环肿瘤细胞与循环肿瘤DNA在结直肠癌中的应用：利弊分析
Carlyn Rose C Tan,Lanlan Zhou,Wafik S El-Deiry
Carlyn Rose C Tan
Circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) are emerging noninvasive multifunctional biomarkers in liquid biopsy allowing for early diagnosis, accurate prognosis, therapeutic target selection, spatiotemporal monitoring ...
Svetlana Balyasnikova,Gina Brown
Svetlana Balyasnikova
The optimal management of rectal cancer is achieved through a shared multidisciplinary decision making process with accurate staging by imaging being critical for treatment planning. Good quality, high-resolution MRI has become the imaging ...
Molecular Subtypes and Personalized Therapy in Metastatic Colorectal Cancer [0.03%]
转移性结直肠癌的分子亚型和个体化治疗
Donna M Graham,Vicky M Coyle,Richard D Kennedy et al.
Donna M Graham et al.
Development of colorectal cancer occurs via a number of key pathways, with the clinicopathological features of specific subgroups being driven by underlying molecular changes. Mutations in key genes within the network of signalling pathways...
Epigenetics and Colorectal Neoplasia: the Evidence for Physical Activity and Sedentary Behavior [0.03%]
表观遗传学与大肠肿瘤变性：体力活动和久坐行为的证据
Elizabeth Hibler
Elizabeth Hibler
Studies demonstrate that regular physical activity and, more recently, limited sedentary behavior are associated with reduced risk of colorectal neoplasia. However, the biological mechanisms of action for physical activity versus sedentary ...
Aspirin and Colorectal Cancer Prevention and Treatment: Is It for Everyone? [0.03%]
阿司匹林与结直肠癌的预防和治疗：适合所有人吗？
Christopher Coyle,Fay Helen Cafferty,Ruth Elizabeth Langley
Christopher Coyle
There is now a considerable body of data supporting the hypothesis that aspirin could be effective in the prevention and treatment of colorectal cancer, and a number of phase III randomised controlled trials designed to evaluate the role of...
Rahul Nayani,Hassan Ashktorab,Hassan Brim et al.
Rahul Nayani et al.
African Americans suffer the highest burden from colorectal cancer (CRC) in the USA. Studies have suggested that healthcare access and poorer utilization of preventive services may be playing more of a role in this disparity. However, Afric...
Robin M J M van Geel,Jos H Beijnen,René Bernards et al.
Robin M J M van Geel et al.
Colorectal cancer has been characterized as a genetically heterogeneous disease, with a large diversity in molecular pathogenesis resulting in differential responses to therapy. However, the currently available validated biomarkers KRAS, BR...
Immunotherapy of Metastatic Colorectal Cancer: Prevailing Challenges and New Perspectives [0.03%]
转移性结直肠癌免疫治疗：面临的挑战和新的视角
Timothy J Zumwalt,Ajay Goel
Timothy J Zumwalt
Patients with recurring or metastatic colorectal cancer (mCRC) have strikingly low long-term survival, while conventional treatments such as chemotherapeutic intervention and radiation therapy marginally improve longevity. Although, many fa...