Using 3D Organoid Cultures to Model Intestinal Physiology and Colorectal Cancer [0.03%]
采用三维类器官培养模型来模拟肠生理及结直肠癌
Sarah P Short,Patricia W Costacurta,Christopher S Williams
Sarah P Short
The three-dimensional (3D) structure of the intestine is a key determinant of differentiation and function; thus, preserving this architecture is an important consideration for studies of intestinal homeostasis and disease. Over the past de...
Lifestyle, Diet, and Colorectal Cancer Risk According to (Epi)genetic Instability: Current Evidence and Future Directions of Molecular Pathological Epidemiology [0.03%]
生活方式、饮食和结直肠癌风险的表观遗传学不稳定性：分子病理流行病学的当前证据及未来方向
Laura A E Hughes,Colinda C J M Simons,Piet A van den Brandt et al.
Laura A E Hughes et al.
Purpose of review: In this review, we describe molecular pathological epidemiology (MPE) studies from around the world that have studied diet and/or lifestyle factors in relation to molecular markers of (epi)genetic pathw...
Apple G Long,Emma T Lundsmith,Kathryn E Hamilton
Apple G Long
Colorectal cancer (CRC) is the fourth most common cancer in both men and women in the United States, resulting in over 55,000 deaths annually. Environmental and genetic factors influence the development of CRC, and inflammation is a critica...
Lifestyle after Colorectal Cancer Diagnosis in Relation to Survival and Recurrence: A Review of the Literature [0.03%]
一项关于生存率和复发与结直肠癌患者生活方式关系的文献综述
Moniek van Zutphen,Ellen Kampman,Edward L Giovannucci et al.
Moniek van Zutphen et al.
Purpose of review: This review summarizes the evidence regarding diet, physical activity, smoking, and body composition after colorectal cancer (CRC) diagnosis in relation to all-cause and CRC-specific mortality and disea...
Current Management of Peritoneal Carcinomatosis From Colorectal Cancer: The Role of Cytoreductive Surgery and Hyperthermic Peritoneal Chemoperfusion [0.03%]
腹膜癌化疗与回温治疗及高位切断手术的作用：结肠癌引发的腹膜癌现行处理方法研究
Ibrahim Nassour,Patricio M Polanco
Ibrahim Nassour
Peritoneal carcinomatosis (PC) from colorectal cancer (CRC) is a disease with a poor prognosis, often thought to be a terminal illness with no hope except for palliative treatment. New therapeutic modalities combining cytoreductive surgery ...
Molecular Biomarkers of Colorectal Cancer and Cancer Disparities: Current Status and Perspective [0.03%]
结直肠癌的分子生物标志物及癌症差异研究：现状与展望
Upender Manne,Trafina Jadhav,Balananda-Dhurjati Kumar Putcha et al.
Upender Manne et al.
This review provides updates on the efforts for the development of prognostic and predictive markers in colorectal cancer based on the race/ethnicity of patients. Since the clinical consequences of genetic and molecular alterations differ w...
Emma M Schatoff,Benjamin I Leach,Lukas E Dow
Emma M Schatoff
The WNT signaling pathway is a critical mediator of tissue homeostasis and repair, and frequently co-opted during tumor development. Almost all colorectal cancers (CRC) demonstrate hyperactivation of the WNT pathway, which in many cases is ...
Microsatellite Instability Pathway and EMAST in Colorectal Cancer [0.03%]
微卫星不稳定途径在结直肠癌中的作用及早期甲基化年龄相关标志物筛查研究
John M Carethers
John M Carethers
Microsatellite instability (MSI) refers to the biochemical detection of frameshifted microsatellite sequences from genomic DNA. Genesis of MSI is due to defective DNA mismatch repair (MMR) that fails to correct post DNA replicative slippage...
Complex Surgical Strategies to Improve Resectability in Borderline-Resectable Disease [0.03%]
改善交界性可切除疾病患者手术切除效果的复杂外科策略
Motaz Qadan,Michael I D&#x;Angelica
Motaz Qadan
Colorectal cancer is the third most common malignancy in the USA and continues to pose a significant epidemiologic problem, despite major advances in the treatment of patients with advanced disease. Up to 50 % of patients will develop metas...
Madeleine Young,Karen R Reed
Madeleine Young
Modelling human diseases in in vitro systems is undisputedly an invaluable research tool, yet there are many limitations. Some of those limitations have been overcome through the introduction of organoid culture systems, which have revoluti...