Targeted Therapy in Metastatic Colorectal Cancer: Current Standards and Novel Agents in Review [0.03%]
转移性结直肠癌的靶向治疗：综述当前标准及新型药物疗法
Rebecca A DeStefanis,Jeremy D Kratz,Philip B Emmerich et al.
Rebecca A DeStefanis et al.
Purpose of review: Treatment options for patients with metastatic colorectal cancer continue to advance as the therapeutic implications of the molecular subtypes of this disease are becoming better understood. DNA sequenc...
Amy V Paschall,Kebin Liu
Amy V Paschall
Colorectal cancer stem cells (CSCs) were initially considered to be a subset of undifferentiated tumor cells with well-defined phenotypic and molecular markers. However, emerging evidence indicates instead that colorectal CSCs are heterogen...
Gut Microbiome and Colon Cancer: Role of Bacterial Metabolites and Their Molecular Targets in the Host [0.03%]
肠道微生物群和结肠癌：细菌代谢产物及其在宿主中的分子靶点的作用
Yangzom D Bhutia,Jiro Ogura,Sathish Sivaprakasam et al.
Yangzom D Bhutia et al.
Purpose of review: The relationship between colonic bacteria and the host is symbiotic, but how communication between the two partners occurs is just beginning to be understood at the molecular level. Here, we highlight s...
Hon Lyn Tan,Matilda Lee,Balamurugan A Vellayappan et al.
Hon Lyn Tan et al.
Purpose of review: Colorectal cancer liver metastasis is a major clinical problem, and surgical resection is the only potentially curative treatment. We seek to discuss various liver-directed therapy modalities and explor...
Sarah F Andres,Kathy N Williams,Anil K Rustgi
Sarah F Andres
Purpose of review: Metastatic colorectal cancer (CRC) is a vexing clinical problem. In contrast to early stage disease, once CRC metastasizes to other organs, long-term survival is compromised. We seek to review the molec...
Is Timing Important? The Role of Diet and Lifestyle during Early Life on Colorectal Neoplasia [0.03%]
时机重要吗？生命早期饮食和生活方式在结直肠肿瘤发生中的作用
Katharina Nimptsch,Kana Wu
Katharina Nimptsch
Purpose of the review: To summarize the current evidence on the most important dietary and lifestyle factors in colorectal carcinogenesis during different stages of a lifetime with special emphasis on studies investigatin...
Laurence Bernier,Svetlana Balyasnikova,Diana Tait et al.
Laurence Bernier et al.
Purpose of review: Pathological complete response is seen in approximately one fifth of rectal cancer patients following neoadjuvant chemoradiation. Since these patients have excellent oncological outcomes, there has been...
The Impact of Novel Radiation Treatment Techniques on Toxicity and Clinical Outcomes In Rectal Cancer [0.03%]
新型放射治疗技术对直肠癌毒副反应及临床预后影响的研究
Lara Hathout,Terence M Williams,Salma K Jabbour
Lara Hathout
Purpose of review: Three-dimensional conformal radiation therapy (3DCRT) has been the standard technique in the treatment of rectal cancer. The use of new radiation treatment technologies such as intensity-modulated radia...
Dietary Patterns and Colorectal Cancer Risk: A Review of 17 Years of Evidence (2000-2016) [0.03%]
饮食模式与结直肠癌风险的关系：2000-2016年证据回顾
Fred K Tabung,Lisa S Brown,Teresa T Fung
Fred K Tabung
Purpose of review: Colorectal cancer (CRC) is a global public health problem, with an estimated 1.4 million cases diagnosed worldwide in 2012. Evidence suggests that diet may be important for primary prevention. ...
Diet, Gut Microbiota, and Colorectal Cancer Prevention: A Review of Potential Mechanisms and Promising Targets for Future Research [0.03%]
饮食、肠道菌群与结直肠癌的预防：潜在机制及未来研究目标展望综述
Mingyang Song,Andrew T Chan
Mingyang Song
Diet plays an important role in the development of colorectal cancer. Emerging data have implicated the gut microbiota in colorectal cancer. Diet is a major determinant for the gut microbial structure and function. Therefore, it has been hy...