Thomas Shupe,Matthew Williams,Alicia Brown et al.
Thomas Shupe et al.
We have developed a method for the decellularization of whole rat livers by perfusion with increasing concentrations of detergents. This procedure resulted in an intact, decellularized organ with an intact liver capsule. These decellularize...
Sylvie Abouna,Robert W Old,Stella Pelengaris et al.
Sylvie Abouna et al.
Pregnancy is a normal physiological condition in which the maternal β-cell mass increases rapidly about two-fold to adapt to new metabolic challenges. We have used a lineage tracing of β-cells to analyse the origin of new β-cells during ...
Reduction of diffusion barriers in isolated rat islets improves survival, but not insulin secretion or transplantation outcome [0.03%]
减少孤立胰岛的扩散屏障可提高其存活率，但并不能改善胰岛素分泌或移植效果
S Janette Williams,Han-Hung Huang,Karen Kover et al.
S Janette Williams et al.
For people with type 1 diabetes and severe hypoglycemic unawareness, islet transplants offer hope for improving the quality of life. However, islet cell death occurs quickly during or after transplantation, requiring large quantities of isl...
Jeffrey M Rosenstein,Janette M Krum,Christiana Ruhrberg
Jeffrey M Rosenstein
Vascular endothelial growth factor (VEGF, VEGFA) is critical for blood vessel growth in the developing and adult nervous system of vertebrates. Several recent studies demonstrate that VEGF also promotes neurogenesis, neuronal patterning, ne...
Joaquim Miguel Vieira,Christiana Ruhrberg,Quenten Schwarz
Joaquim Miguel Vieira
The secreted glycoprotein vascular endothelial growth factor A (VEGF or VEGFA) affects many different cell types and modifies a wide spectrum of cellular behaviors in tissue culture models, including proliferation, migration, differentiatio...
Yee-Hung M Chan,Wallace F Marshall
Yee-Hung M Chan
How size is controlled is a fundamental question in biology. In this review, we discuss the use of scaling relationships-for example, power-laws of the form y∝x(α)-to provide a framework for comparison and interpretation of size measureme...
The regulation of organ size in Drosophila: physiology, plasticity, patterning and physical force [0.03%]
果蝇器官大小的调控：生理、可塑性、图案及物理力量
Alexander W Shingleton
Alexander W Shingleton
The correct regulation of organ size is a fundamental developmental process, the failure of which can compromise organ function and organismal integrity. Consequently, the mechanisms that regulate organ size have been subject to intense res...
Yasmin Alam-Faruque,Emily C Dimmer,Rachael P Huntley et al.
Yasmin Alam-Faruque et al.
The gene ontology (go) resource provides dynamic controlled vocabularies to aid in the description of the functional attributes and subcellular locations of gene products from all taxonomic groups (www.geneontology.org). A renal-focused cur...
Jordan A Kreidberg
Jordan A Kreidberg
Kidney development has been studied over the past sixty years as a model of embryonic induction during organogenesis. Wilms' tumor-1 (WT1), that encodes a transcription factor and RNA-binding protein, was one of the first tumor suppressor g...
Modeling bidirectional transcription using silkmoth chorion gene promoters [0.03%]
用大蚕蛾卵壳基因启动子模拟双向转录
Rena Lecanidou,Argyris Papantonis
Rena Lecanidou
Bidirectional transcription is an interesting feature of eukaryotic genomes; yet not all aspects of its mechanism are understood. Silkmoth choriogenesis is a model system for studying transcriptional regulation at the initiation level. As c...