MLPH/RAB3A accelerates the differentiation of pancreatic stem cells to islet β-cells to control blood glucose in diabetic rats [0.03%]
MLPH/RAB3A通过促进胰腺干细胞向胰岛β细胞分化来控制糖尿病大鼠血糖水平
Junling Shan,Huifeng Wang,Guangyu Zhu
Junling Shan
Background: This study aimed to determine the potential mechanism by which pancreatic stem cell-derived beta cells (PSCs-β) assist in the body's glucose-lowering capacity in type 1 diabetes (T1D) rats. ...
Adipose-derived mesenchymal stem cells-derived exosomes containing nano-pearl powder water-soluble matrix promote osteogenic differentiation of MC3T3-E1 cells [0.03%]
脂肪来源的间充质干细胞衍生的外泌体中含纳米珍珠粉水溶性基质可促进MC3T3-E1细胞成骨分化
Ling Chen,QiuHua Mao,WenBai Zhang et al.
Ling Chen et al.
Objective: To explore the synergistic effect of nano-pearl powder (NPP) and adipose-derived stem cell exosomes (ADSC-Exos) on the osteogenic potential of MC3T3-E1 cells. ...
Comparison of vascular remodeling between a bioresorbable poly-L-lactic acid scaffold and a bare metal stent: a 6-month angiography and intravascular ultrasound analysis in porcine iliac arteries [0.03%]
可吸收聚乳酸支架与裸金属支架血管重建的对比研究：猪髂动脉6个月造影及血管内超声分析
Keita Hayashi,Hideaki Obara,Naoki Fujimura et al.
Keita Hayashi et al.
Animal experimental studies involving the Igaki-Tamai stent (ITS), a bioresorbable poly-l-lactic acid scaffold, in peripheral arteries are limited, and existing studies evaluated only short-term (3-month) outcomes. This study compared arter...
Comparative Study
Organogenesis. 2026 Dec 31;22(1):2630543. DOI:10.1080/15476278.2026.2630543 2026
Optimization of TX-100/SDS-based decellularized vascular material using ultrasound and chemical treatment: evaluation of structure and biosafety [0.03%]
采用超声波和化学处理优化TX-100/SDS脱细胞血管材料：结构及生物安全评价
Hongguang Chen,Xiaomei Bie,Lifang Hao et al.
Hongguang Chen et al.
Decellularized blood vessels with low immunogenicity and excellent biocompatibility are promising for tissue engineering and clinical applications. However, current decellularization methods face limitations in cell removal efficiency, matr...
A novel tissue-engineered stent graft combining decellularized scaffold and bioresorbable stent: a pilot feasibility study in a porcine model [0.03%]
一种组织工程移植物的新型药物洗脱血管支架：猪模型中的可行性研究
Tatsuya Shimogawara,Kentaro Matsubara,Kazuki Tajima et al.
Tatsuya Shimogawara et al.
Endovascular aneurysm repair (EVAR) is a widely accepted treatment for aortic pathologies owing to its minimally invasive nature. However, long-term complications, such as stent graft migration and infection, remain unresolved, primarily du...
Mechanism of CGF in osteogenic differentiation of periodontal ligament stem cells through the Wnt pathway [0.03%]
Wnt信号通路介导的CGF促进牙周韧带干细胞成骨分化的机制研究
Bing Zhou,Wentu Zhou,Xin Li et al.
Bing Zhou et al.
Objective: Periodontal ligament stem cells (PDLSCs), undifferentiated mesenchymal cells with multipotent differentiation and self-renewal capacities, constitute the optimal MSC population for periodontal regeneration. Thi...
Exosomal miR-29a-3p derived from bone marrow stromal cells suppresses malignant behavior of NSCLC by regulating DNMT3A/JAK2/STAT3 axis [0.03%]
骨髓stromal细胞衍生的外泌体miR-29a-3p通过调节DNMT3A/JAK2/STAT3轴抑制非小细胞肺癌的恶性行为
Chao Su,Xiaoliang Han,Kang Zhang
Chao Su
MicroRNAs (miRNAs) can be transported to tumor cells through exosomes secreted by bone marrow mesenchymal stem cells (BMSC-Exos) and exert regulatory functions within cells. Here, we aim to investigate the functional mechanism of miR-29a-3p...
SS-31 Targets NOS2 to Enhance Osteogenic Differentiation in Aged BMSCs by Restoring Mitochondrial Function [0.03%]
SS-31通过恢复线粒体功能增强BMSCs成骨分化的靶点NOS2的作用
Sen Duan,Qindong Zhang,Jinqiang Zhu et al.
Sen Duan et al.
This study delves into the rejuvenating effects of SS-31 on aged human Bone Marrow-Derived Mesenchymal Stem Cells (BM-MSCs), focusing on its potential to restore their diminished osteogenic differentiation capacity, a critical issue in geri...
Baicalein Alleviates Lithium-Pilocarpine-Induced Status Epilepticus by Regulating DNMT1/GABRD Pathway in Rats [0.03%]
黄芩素通过调节DNMT1/GABRD信号通路缓解大鼠局灶性脑缺血再灌注诱发的癫痫持续状态
Zhenggang Wu,Jing Liu,Deju Yin et al.
Zhenggang Wu et al.
Background: Epilepsy is a common disease of the nervous system. Recent advances in epigenetics have revealed DNA methylation as a key mechanism in epilepsy pathogenesis, particularly through dysregulation of GABAergic sig...
ORM1 Mediates Ln-IgG-Induced Podocyte Damage and Autophagy via the AMPK/mTOR Signaling [0.03%]
ORM1通过AMPK/mTOR信号传导介导LN-IgG诱导的足细胞损伤和自噬
Jie Chen,Libin Zou,Lu Liu et al.
Jie Chen et al.
Podocyte damage is a central feature of lupus nephritis (LN), making the identification of potential therapeutic targets to prevent podocyte injury and improve treatment outcomes essential. ORM1 has been suggested as a significant candidate...