Mechanism of CGF in osteogenic differentiation of periodontal ligament stem cells through the Wnt pathway [0.03%]
Wnt信号通路介导的CGF促进牙周韧带干细胞成骨分化的机制研究
Bing Zhou,Wentu Zhou,Xin Li et al.
Bing Zhou et al.
Objective: Periodontal ligament stem cells (PDLSCs), undifferentiated mesenchymal cells with multipotent differentiation and self-renewal capacities, constitute the optimal MSC population for periodontal regeneration. Thi...
Exosomal miR-29a-3p derived from bone marrow stromal cells suppresses malignant behavior of NSCLC by regulating DNMT3A/JAK2/STAT3 axis [0.03%]
骨髓stromal细胞衍生的外泌体miR-29a-3p通过调节DNMT3A/JAK2/STAT3轴抑制非小细胞肺癌的恶性行为
Chao Su,Xiaoliang Han,Kang Zhang
Chao Su
MicroRNAs (miRNAs) can be transported to tumor cells through exosomes secreted by bone marrow mesenchymal stem cells (BMSC-Exos) and exert regulatory functions within cells. Here, we aim to investigate the functional mechanism of miR-29a-3p...
SS-31 Targets NOS2 to Enhance Osteogenic Differentiation in Aged BMSCs by Restoring Mitochondrial Function [0.03%]
SS-31通过恢复线粒体功能增强BMSCs成骨分化的靶点NOS2的作用
Sen Duan,Qindong Zhang,Jinqiang Zhu et al.
Sen Duan et al.
This study delves into the rejuvenating effects of SS-31 on aged human Bone Marrow-Derived Mesenchymal Stem Cells (BM-MSCs), focusing on its potential to restore their diminished osteogenic differentiation capacity, a critical issue in geri...
Baicalein Alleviates Lithium-Pilocarpine-Induced Status Epilepticus by Regulating DNMT1/GABRD Pathway in Rats [0.03%]
黄芩素通过调节DNMT1/GABRD信号通路缓解大鼠局灶性脑缺血再灌注诱发的癫痫持续状态
Zhenggang Wu,Jing Liu,Deju Yin et al.
Zhenggang Wu et al.
Background: Epilepsy is a common disease of the nervous system. Recent advances in epigenetics have revealed DNA methylation as a key mechanism in epilepsy pathogenesis, particularly through dysregulation of GABAergic sig...
ORM1 Mediates Ln-IgG-Induced Podocyte Damage and Autophagy via the AMPK/mTOR Signaling [0.03%]
ORM1通过AMPK/mTOR信号传导介导LN-IgG诱导的足细胞损伤和自噬
Jie Chen,Libin Zou,Lu Liu et al.
Jie Chen et al.
Podocyte damage is a central feature of lupus nephritis (LN), making the identification of potential therapeutic targets to prevent podocyte injury and improve treatment outcomes essential. ORM1 has been suggested as a significant candidate...
Pnky Modulates Neural Stem Cell Proliferation and Differentiation Through Activation of Wnt/β-Catenin Signaling Pathway [0.03%]
Pnky通过激活Wnt/β-catenin信号通路调控神经干细胞的增殖和分化
Haidong Wu,Jing Huang,Xiaojing Li et al.
Haidong Wu et al.
Neural stem cell (NSC) possess the essential properties of pluripotency and self-renewal, making them promising candidates for the treatment of neurological disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), and spinal co...
MicroRNA-214-3p Delivered by Bone Marrow Mesenchymal Stem Cells-Secreted Exosomes Affects Oxidative Stress in Alzheimer's Disease Rats by Targeting CD151 [0.03%]
骨髓间充质干细胞分泌的外泌体递送microRNA-214-3p通过靶向CD151影响阿尔茨海默病大鼠氧化应激状态
Luzy Zhang
Luzy Zhang
Objective: This study probed the effect of targeted regulation of CD151 by microRNA-214-3p (miR-214-3p) delivered by bone marrow mesenchymal stem cells-secreted exosomes (BMSCs-exo) on oxidative stress and apoptosis of ne...
Optimized Individualized Nursing Improves Recovery and Reduces Complications in ICU Patients with Severe Pneumonia [0.03%]
优化的个体化护理可改善重症肺炎ICU患者的恢复并减少并发症
Linjuan Wu,Jingchuan Lin
Linjuan Wu
Objective: This study evaluates the effectiveness of optimized individualized nursing interventions on clinical outcomes in intensive care unit (ICU) patients with severe pneumonia. ...
Randomized Controlled Trial
Organogenesis. 2025 Dec;21(1):2489670. DOI:10.1080/15476278.2025.2489670 2025
Calcium Imaging in Vivo: How to Correctly Select and Apply Fiber Optic Photometric Indicators [0.03%]
钙成像技术在活体中的应用：如何正确选择和运用光纤光度检测指标
Lanxia Wu,Wenxuan Sun,Linjie Huang et al.
Lanxia Wu et al.
Fiber-photometric is a novel optogenetic method for recording neural activity in vivo, which allows the use of calcium indicators to observe and study the relationship between neural activity and behavior in free-ranging animals. Calcium in...
Correlation of MicroRNA-31 with Endometrial Receptivity in Patients with Repeated Implantation Failure of In Vitro Fertilization and Embryo Transfer [0.03%]
体外受精胚胎移植反复植入失败患者microRNA-31与子宫内膜接受性的相关性研究
Yan Tan,Bijun Du,Xixi Chen et al.
Yan Tan et al.
Objective: This trial probed the correlation between miR-31 expression and endometrial receptivity (ER) in patients with repeated implantation failure (RIF) of in vitro fertilization and embryo transfer (IVF-ET). ...