SS-31 Targets NOS2 to Enhance Osteogenic Differentiation in Aged BMSCs by Restoring Mitochondrial Function [0.03%]
SS-31通过恢复线粒体功能增强BMSCs成骨分化的靶点NOS2的作用
Sen Duan,Qindong Zhang,Jinqiang Zhu et al.
Sen Duan et al.
This study delves into the rejuvenating effects of SS-31 on aged human Bone Marrow-Derived Mesenchymal Stem Cells (BM-MSCs), focusing on its potential to restore their diminished osteogenic differentiation capacity, a critical issue in geri...
Baicalein Alleviates Lithium-Pilocarpine-Induced Status Epilepticus by Regulating DNMT1/GABRD Pathway in Rats [0.03%]
黄芩素通过调节DNMT1/GABRD信号通路缓解大鼠局灶性脑缺血再灌注诱发的癫痫持续状态
Zhenggang Wu,Jing Liu,Deju Yin et al.
Zhenggang Wu et al.
Background: Epilepsy is a common disease of the nervous system. Recent advances in epigenetics have revealed DNA methylation as a key mechanism in epilepsy pathogenesis, particularly through dysregulation of GABAergic sig...
ORM1 Mediates Ln-IgG-Induced Podocyte Damage and Autophagy via the AMPK/mTOR Signaling [0.03%]
ORM1通过AMPK/mTOR信号传导介导LN-IgG诱导的足细胞损伤和自噬
Jie Chen,Libin Zou,Lu Liu et al.
Jie Chen et al.
Podocyte damage is a central feature of lupus nephritis (LN), making the identification of potential therapeutic targets to prevent podocyte injury and improve treatment outcomes essential. ORM1 has been suggested as a significant candidate...
Pnky Modulates Neural Stem Cell Proliferation and Differentiation Through Activation of Wnt/β-Catenin Signaling Pathway [0.03%]
Pnky通过激活Wnt/β-catenin信号通路调控神经干细胞的增殖和分化
Haidong Wu,Jing Huang,Xiaojing Li et al.
Haidong Wu et al.
Neural stem cell (NSC) possess the essential properties of pluripotency and self-renewal, making them promising candidates for the treatment of neurological disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), and spinal co...
MicroRNA-214-3p Delivered by Bone Marrow Mesenchymal Stem Cells-Secreted Exosomes Affects Oxidative Stress in Alzheimer's Disease Rats by Targeting CD151 [0.03%]
骨髓间充质干细胞分泌的外泌体递送microRNA-214-3p通过靶向CD151影响阿尔茨海默病大鼠氧化应激状态
Luzy Zhang
Luzy Zhang
Objective: This study probed the effect of targeted regulation of CD151 by microRNA-214-3p (miR-214-3p) delivered by bone marrow mesenchymal stem cells-secreted exosomes (BMSCs-exo) on oxidative stress and apoptosis of ne...
Optimized Individualized Nursing Improves Recovery and Reduces Complications in ICU Patients with Severe Pneumonia [0.03%]
优化的个体化护理可改善重症肺炎ICU患者的恢复并减少并发症
Linjuan Wu,Jingchuan Lin
Linjuan Wu
Objective: This study evaluates the effectiveness of optimized individualized nursing interventions on clinical outcomes in intensive care unit (ICU) patients with severe pneumonia. ...
Randomized Controlled Trial
Organogenesis. 2025 Dec;21(1):2489670. DOI:10.1080/15476278.2025.2489670 2025
Calcium Imaging in Vivo: How to Correctly Select and Apply Fiber Optic Photometric Indicators [0.03%]
钙成像技术在活体中的应用：如何正确选择和运用光纤光度检测指标
Lanxia Wu,Wenxuan Sun,Linjie Huang et al.
Lanxia Wu et al.
Fiber-photometric is a novel optogenetic method for recording neural activity in vivo, which allows the use of calcium indicators to observe and study the relationship between neural activity and behavior in free-ranging animals. Calcium in...
Correlation of MicroRNA-31 with Endometrial Receptivity in Patients with Repeated Implantation Failure of In Vitro Fertilization and Embryo Transfer [0.03%]
体外受精胚胎移植反复植入失败患者microRNA-31与子宫内膜接受性的相关性研究
Yan Tan,Bijun Du,Xixi Chen et al.
Yan Tan et al.
Objective: This trial probed the correlation between miR-31 expression and endometrial receptivity (ER) in patients with repeated implantation failure (RIF) of in vitro fertilization and embryo transfer (IVF-ET). ...
Tetramethylpyrazine Confers Protection Against Oxidative Stress and NLRP3-Dependent Pyroptosis in Rats with Endometriosis [0.03%]
四甲基吡嗪对氧化应激和依赖NLRP3的焦亡发挥保护作用于子宫内膜异位症大鼠模型中
Ke Xu,Mingzhe Zhang,Xiaofeng Zou et al.
Ke Xu et al.
Tetramethylpyrazine (TMP) has been confirmed to suppress inflammation in endometriosis (EMs). Herein, this study investigated whether and how TMP affected NLRP3 inflammasomes and oxidative stress in EMs. After establishment of an EMs rat mo...
The Role of SUMO1 Modification of SOX9 in Cartilage Development Stimulated by Zinc Ions in Mice [0.03%]
锌离子诱导的SOX9 SUMO1修饰在软骨发育中的作用机制研究
Na Xue,Jing Zhao,Jing Yin et al.
Na Xue et al.
Zinc ions play a pivotal role in facilitating the development of cartilage in mice. Nevertheless, the precise underlying mechanism remains elusive. Our investigation was centered on elucidating the impact of zinc deficiency on cartilage mat...