Geoffrey M Fleming
Geoffrey M Fleming
Support of renal function in modern times encompasses a wide array of methods and clinical scenarios, from the ambulatory patient to the critically ill. The ability to safely and routinely deliver ongoing organ support in the outpatient set...
GDNF/Ret signaling and renal branching morphogenesis: From mesenchymal signals to epithelial cell behaviors [0.03%]
GDNF/Ret信号与肾分支形态发生：从间充质信号到上皮细胞行为
Frank Costantini
Frank Costantini
Signaling by GDNF through the Ret receptor tyrosine kinase is required for the normal growth and morphogenesis of the ureteric bud (UB) during kidney development. Recent studies have sought to understand the precise role of Ret signaling in...
Organogenetic tolerance [0.03%]
器官生成耐受性
Marc R Hammerman
Marc R Hammerman
Transplantation therapy for humans is limited by insufficient availability of donor organs and outcomes are complicated by the toxicity of immunosuppressive drugs. Xenotransplantation is a strategy to overcome supply problems. Implantation ...
Directed assembly of cell-laden hydrogels for engineering functional tissues [0.03%]
用于工程组织的含有细胞的水凝胶的定向组装
Nezamoddin N Kachouie,Yanan Du,Hojae Bae et al.
Nezamoddin N Kachouie et al.
Tissue engineering aims to develop functionalized tissues for organ replacement or restoration. Biodegradable scaffolds have been used in tissue engineering to support cell growth and maintain mechanical and biological properties of tissue ...
Kristine P Krafts
Kristine P Krafts
As living beings who encounter every kind of traumatic event from paper cut to myocardial infarction, we must possess ways to heal damaged tissues. While some animals are able to regrow complete body parts following injury (such as the eart...
Michael Lovett,George Eng,Jonathan A Kluge et al.
Michael Lovett et al.
Vascular surgeries such as coronary artery bypass require small diameter vascular grafts with properties that are not available at this time. Approaches using synthetic biomaterials have been not completely successful in producing non-throm...
Comparative Study
Organogenesis. 2010 Oct-Dec;6(4):217-24. DOI:10.4161/org.6.4.13407 2010
S Steven Potter,Eric W Brunskill,Larry T Patterson
S Steven Potter
The kidney represents an excellent model system for learning the principles of organogenesis. It is intermediate in complexity, and employs many commonly used developmental processes. As such, kidney development has been the subject of inte...
Tissue engineering of a collagen-based vascular media: Demonstration of functionality [0.03%]
基于胶原的血管中膜组织工程学：功能演示
Stacey C Schutte,Zhenzhen Chen,Kelvin G M Brockbank et al.
Stacey C Schutte et al.
The property of vasoactivity is important for both resistance vessels and larger arteries. Evaluation of smooth muscle cell phenotype is often done in place of functional testing in engineered tissues, assuming a direct correlation between ...
Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers [0.03%]
基于氨基醇的聚酯胺弹性体微流控支架用于组织工程中的可降解微流体支架
Jane Wang,Christopher J Bettinger,Robert S Langer et al.
Jane Wang et al.
Biodegradable polymers with high mechanical strength, flexibility and optical transparency, optimal degradation properties and biocompatibility are critical to the success of tissue engineered devices and drug delivery systems. Most biodegr...
Human umbilical cord perivascular cells (HUCPVC): A mesenchymal cell source for dermal wound healing [0.03%]
人脐带围血管细胞(HUCPVC)：一种用于真皮伤口修复的间充质细胞来源
Nazlee Zebardast,David Lickorish,John E Davies
Nazlee Zebardast
Human bone marrow mesenchymal stem cells (hBM-MSC) have recently been employed in the clinical treatment of challenging skin defects. We have described an MSC population that can be easily harvested from human umbilical cord perivascular ti...