Shuling Fan,Ben Margolis
Shuling Fan
Cilia are microtubule-based organelles that arise from the centrosome and project from the surface of many cells. Defects in cilia-localized proteins are felt to lead to polycystic kidney disease as well as ciliopathies with multiple organ ...
Engraftment of cells from porcine islets of Langerhans following transplantation of pig pancreatic primordia in non-immunosuppressed diabetic rhesus macaques [0.03%]
非免疫抑制猕猴移植猪胰腺始祖细胞后兰格汉斯岛细胞的植入情况
Sharon A Rogers,Piyush Tripathi,Thalachallour Mohanakumar et al.
Sharon A Rogers et al.
Transplantation therapy for human diabetes is limited by the toxicity of immunosuppressive drugs. If toxicity can be minimized, there will still be a shortage of human donor organs. Xenotransplantation of porcine islets is a strategy to ove...
Benedetta Bussolati
Benedetta Bussolati
A rapid in vivo assay system for analyzing the organogenetic capacity of human kidney cells [0.03%]
一种用于分析人类肾细胞器官发生能力的快速体内检测系统
Tsahi Noiman,Ella Buzhor,Sally Metsuyanim et al.
Tsahi Noiman et al.
Transplantation of human kidney-derived cells is a potential therapeutic modality for promoting regeneration of diseased renal tissue. However, assays that determine the ability of candidate populations for renal cell therapy to undergo app...
Scott Reule,Sandeep Gupta
Scott Reule
Given its complexity, high metabolic activity and excretory functions, the kidney is particularly susceptible to acute ischemic and toxin-mediated injury. Current therapies do not facilitate kidney regeneration, and there is an increasing i...
Potential applications of germline cell-derived pluripotent stem cells in organ regeneration [0.03%]
生殖细胞来源的多能干细胞在器官再生中的潜在应用
Sharmila Fagoonee,Rinaldo Pellicano,Lorenzo Silengo et al.
Sharmila Fagoonee et al.
Impressive progress has been made since the turn of the century in the field of stem cells. Different types of stem cells have now been isolated from different types of tissues. Pluripotent stem cells are the most promising cell source for ...
Mihaela Crisan,Mirko Corselli,Chien-Wen Chen et al.
Mihaela Crisan et al.
Mesenchymal stem cells proliferate extensively in cultures of unselected, total cell isolates from multiple fetal and adult organs. Perivascular cells, principally pericytes surrounding capillaries and microvessels, but also adventitial cel...
Ciro Tetta,Stefania Bruno,Valentina Fonsato et al.
Ciro Tetta et al.
Microvesicles (MVs) are released by almost all cells in resting and activated conditions. First described several years ago, it is only recently that their mechanisms of action are being elucidated, and their potential role in health and di...
The role of multipotent marrow stromal cells (MSCs) in tissue regeneration [0.03%]
骨髓多能基质细胞(MSCs)在组织再生中的作用
Florian Tögel,Christof Westenfelder
Florian Tögel
An extensive body of preclinical and clinical data has shown that administration of adult multipotent marrow stromal cells (MSCs) effectively ameliorates experimental and clinical conditions of many different organ systems. Differentiation ...
Selecting the optimal cell for kidney regeneration: fetal, adult or reprogrammed stem cells [0.03%]
选择肾脏再生的最优细胞：胎儿、成人还是重编程干细胞？
Orit Harari-Steinberg,Oren Pleniceanu,Benjamin Dekel
Orit Harari-Steinberg
Chronic kidney disease (CKD) is a progressive loss in renal function over a period of months or years. End-stage renal disease (ESRD) or stage 5 CKD ensues when renal function deteriorates to under 15% of the normal range. ESRD requires eit...