Renal organogenesis: what can it tell us about renal repair and regeneration? [0.03%]
肾器官发生：其对肾脏修复和再生有何启示？
Melissa H Little
Melissa H Little
The increasing prevalence of chronic kidney disease in the absence of new treatment modalities has become a strong driver for innovation in nephrology. An increasing understanding of stem cell biology has kindled the prospects of regenerati...
Jacek Topczewski,Rodney M Dale,Barbara E Sisson
Jacek Topczewski
Out of the several signaling pathways controlling craniofacial development, the role of planar cell polarity (PCP) signaling is relatively poorly understood. This pathway, originally identified as a mechanism to maintain cell polarity withi...
Sarah M Romereim,Andrew T Dudley
Sarah M Romereim
Despite extensive genetic analysis of the dynamic multi-phase process that transforms a small population of lateral plate mesoderm into the mature limb skeleton, the mechanisms by which signaling pathways regulate cellular behaviors to gene...
PCP goes organic [0.03%]
有机PCP
Thomas J Carroll
Thomas J Carroll
The planar cell polarity pathway in vertebrate epidermal development, homeostasis and repair [0.03%]
平面细胞极性信号通路在脊椎动物皮肤发育、稳态和修复中的功能研究
Sebastian Dworkin,Stephen M Jane,Charbel Darido
Sebastian Dworkin
The planar cell polarity (PCP) pathway plays a critical role in diverse developmental processes that require coordinated cellular movement, including neural tube closure and renal tubulogenesis. Recent studies have demonstrated that this pa...
Laura L Yates,Charlotte H Dean
Laura L Yates
The clinical burden of both adult and neonatal lung disease worldwide is substantial; in the UK alone, respiratory disease kills one in four people. It is increasingly recognized that genes and pathways that regulate lung development, may b...
Yuki Sugiyama,Frank J Lovicu,John W McAvoy
Yuki Sugiyama
The major role of the eye lens is to transmit and focus images onto the retina. For this function, the lens needs to develop and maintain the correct shape, notably, the precise curvature and high-level order and organization of its element...
Thomas J Carroll,Amrita Das
Thomas J Carroll
Planar cell polarity (PCP) describes the coordinated polarization of tissue cells in a direction that is orthogonal to their apical/basal axis. In the last several years, studies in flies and vertebrates have defined evolutionarily conserve...
Saw Myat Thanda W Maung,Andreas Jenny
Saw Myat Thanda W Maung
In all multicellular organisms, epithelial cells are not only polarized along the apical-basal axis, but also within the epithelial plane, giving cells a sense of direction. Planar cell polarity (PCP) signaling regulates establishment of po...
Benjamin Levi,Samantha Brugman,Victor W Wong et al.
Benjamin Levi et al.
Cleft palate represents the second most common birth defect and carries substantial physiologic and social challenges for affected patients, as they often require multiple surgical interventions during their lifetime. A number of genes have...