Tissue stiffness dictates development, homeostasis, and disease progression [0.03%]
组织硬度决定发育、稳态和疾病进展
Andrew M Handorf,Yaxian Zhou,Matthew A Halanski et al.
Andrew M Handorf et al.
Tissue development is orchestrated by the coordinated activities of both chemical and physical regulators. While much attention has been given to the role that chemical regulators play in driving development, researchers have recently begun...
Relevance of the plasma membrane calcium-ATPase in the homeostasis of calcium in the fetal liver [0.03%]
胎肝钙稳态的血浆膜钙依赖性酶的作用
Blanca Delgado-Coello,Jaime Mas-Oliva
Blanca Delgado-Coello
During the early stages of development, the embryo depends on the placenta as provider of oxygen and calcium, among other essential compounds. Although fetal liver accomplishes a well-known haematopoietic function, its contribution to calci...
Freezing/Thawing without Cryoprotectant Damages Native but not Decellularized Porcine Renal Tissue [0.03%]
无冷冻保护剂冻存对天然和去细胞猪肾脏组织的损伤作用不同
Nafiseh Poornejad,Timothy S Frost,Daniel R Scott et al.
Nafiseh Poornejad et al.
Whole organ decellularization of porcine renal tissue and recellularization with a patient's own cells would potentially overcome immunorejection, which is one of the most significant problems with allogeneic kidney transplantation. However...
Rui Gao,Wanquan Wu,Junxi Xiang et al.
Rui Gao et al.
Background and aims: Using decellularized scaffold to reengineer liver tissue is a promising alternative therapy for end-stage liver diseases. Though the decellularized human liver matrix is the ideal scaffold for reconst...
Large-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation [0.03%]
大规模的人类诱导多能干细胞来源的神经干细胞/早期神经前体细胞的生成及其神经元分化
Leonardo D&#x;Aiuto,Yun Zhi,Dhanjit Kumar Das et al.
Leonardo D&#x;Aiuto et al.
Induced pluripotent stem cell (iPSC)-based technologies offer an unprecedented opportunity to perform high-throughput screening of novel drugs for neurological and neurodegenerative diseases. Such screenings require a robust and scalable me...
Maturation of embryonic tissues in a lymph node: a new approach for bioengineering complex organs [0.03%]
胚胎组织在淋巴结中的成熟：一种生物工程复杂器官的新方法
Maria Giovanna Francipane,Eric Lagasse
Maria Giovanna Francipane
Given our recent finding that the lymph node (LN) can serve as an in vivo factory to generate complex structures like liver, pancreas, and thymus, we investigated whether LN could also support early development and maturation from several m...
An unusual colon atresia in a calf: at the junction of the distal loop and transverse colon. A brief overview [0.03%]
犊牛罕见的结肠闭锁：发生在远端回转和横 Colon结合部的一个简短综述
Matilde Lombardero,María del Mar Yllera
Matilde Lombardero
Congenital defects are those abnormalities present at birth. During embryogenesis, many anomalies can occur. The primitive gut tube lengthens quickly and rotates, allowing the gastrointestinal tract acquire its final position and orientatio...
Case Reports
Organogenesis. 2014;10(3):312-6. DOI:10.4161/15476278.2014.970090 2014
Age associated communication between cells and matrix: a potential impact on stem cell-based tissue regeneration strategies [0.03%]
细胞与胞外基质间的通讯随年龄变化的规律及其对基于干细胞组织再生策略的影响研究
Kevin Lynch,Ming Pei
Kevin Lynch
A recent paper demonstrated that decellularized extracellular matrix (DECM) deposited by synovium-derived stem cells (SDSCs), especially from fetal donors, could rejuvenate human adult SDSCs in both proliferation and chondrogenic potential,...
Rajprasad Loganathan,Charles D Little,Pranav Joshi et al.
Rajprasad Loganathan et al.
The tissue scale deformations (≥ 1 mm) required to form an amniote embryo are poorly understood. Here, we studied ∼400 μm-sized explant units from gastrulating quail embryos. The explants deformed in a reproducible manner when grown usin...
Finding the winning combination. Combinatorial screening of three dimensional niches to guide stem cell osteogenesis [0.03%]
寻找获胜组合。三维生态位组合筛选指导干细胞成骨分化
Adnan Memic,Ali Khademhosseini
Adnan Memic
The ability to predict and guide stem cell differentiation remains a major challenge in regenerative medicine. Numerous dynamic microenvironmental cues often provide synergistic or combinatorial signals that influence the fate of stem cells...