Time-resolved miRNA-mRNA integrated analysis reveals the miRNA-mRNA networks underlying plasma membrane damage-dependent senescence and DNA damage response-dependent senescence in WI-38 normal human fibroblasts [0.03%]
时间分辨的miRNA-mRNA整合分析揭示了与WI-38人正常成纤维细胞的质膜损伤依赖性衰老和DNA损伤应答依赖性衰老相关的miRNA-mRNA网络
Yatzu Chiu,Risa Ishida,Yohsuke Moriyama et al.
Yatzu Chiu et al.
Cellular senescence is a stable cell cycle arrest associated with upregulated inflammatory responses. Senescent cells contribute to various pathological and physiological processes including organismal ageing and cancer. Cellular senescence...
Opposing mechanisms by which miRNAs mediate distinct Nrf1 and Nrf2 regulation of epithelial-mesenchymal transition in hepatocellular carcinoma [0.03%]
调控肝癌上皮间质转化的Nrf1和Nrf2的不同miRNA介导机制
Juan Chen,Jing Feng,Yuping Zhu et al.
Juan Chen et al.
Accumulation of various genetics and epigenetics alterations are accepted to result in the initiation and progression of hepatocellular carcinoma (HCC), and its high metastasis is viewed as a critical bottleneck leading to its treatment fai...
Developing the risk prediction model (ProlncSig) from lipoxygenase pathway-related lncRNAs for prognosis prediction in breast cancer [0.03%]
基于脂氧合酶通路相关长链非编码RNA的乳腺癌预后预测风险模型（ProlincSig）的研发
Xiaoyu Fu,Weixing Wang,Bradley M Downs et al.
Xiaoyu Fu et al.
Alterations in cellular metabolism are known to play a crucial role in the development and progression of cancer. The lipoxygenase pathway, which controls unsaturated fatty acid metabolism, has been shown to regulate tumour progression and ...
Ting-Yu Lin,Yasmin Stone,Sebastian Glatt
Ting-Yu Lin
Pseudouridylation (Ψ) is a highly abundant and conserved RNA modification that is present in all three domains of life. The incorporation of Ψ can affect the stability of RNAs, modulate their interaction patterns, and regulate many other ...
Dynamic shifts in isomiR profiles during parasite maturation of Fasciola hepatica [0.03%]
肝片吸虫寄生过程中miRNA异构体(isomiR)谱动态变化
Dayna Sais,Sumaiya Chowdhury,Phuong Thao Nguyen et al.
Dayna Sais et al.
We investigated the isomiR profiles of the parasitic worm Fasciola hepatica across three developmental stages: newly excysted juveniles (NEJ), juveniles (JUV), and adults. Our analysis revealed a distinct shift in isomiR distribution during...
Impact of Gemin5 in protein synthesis: phosphoresidues of the dimerization domain regulate ribosome binding [0.03%]
Gemin5对蛋白质合成的影响：二聚化结构域的磷蛋白残基调节核糖体结合
Salvador Abellan,Alejandra Escos,Rosario Francisco-Velilla et al.
Salvador Abellan et al.
RNA-binding proteins are involved in all steps of gene expression. Their malfunction has important consequences for cell growth through dysregulation of protein synthesis events leading to cancer. Gemin5 is a predominantly cytoplasmic prote...
Carrot and stick: how RNase R contributes to function and destruction of the translation machinery [0.03%]
胡萝卜与大棒：RNase R如何影响翻译机制的功能和降解
Helge Paternoga,Lyudmila Dimitrova-Paternoga
Helge Paternoga
RNA is fundamental for life, and its homoeostasis is a critical contributor to cellular growth and adaptation to stress. Key RNA species include messenger RNA (mRNA) and non-coding RNAs, such as transfer RNA (tRNA), or ribosomal RNA (rRNA),...
"Derailing the host machinery to achieve replication: how Viroid and Viroid-like RNAs successfully copy their genomes in hostile territory" [0.03%]
“利用宿主机器实现自我复制：如何在恶劣环境下成功复制基因组的小分子RNA（类）病原体”
Kriton Kalantidis,Martha Tselika,Paraskevi Kallemi et al.
Kriton Kalantidis et al.
Circular infectious RNAs have been known for several decades. Their biology has been intriguing from the beginning partly due to the antithesis between their efficiency and tiny size. Amongst infectious circular RNAs viroids hold a special ...
Kunal M Shah,Alex F F Crozier,Anika Assaraf et al.
Kunal M Shah et al.
MicroRNA-mediated gene silencing is a conserved mechanism of post-transcriptional gene regulation across metazoans. It depends on base pairing between small RNAs and mRNAs, and on protein complexes including the RNA-induced silencing comple...
The hidden power of antisense long non-coding RNAs: a dive into a novel regulatory layer mediated by double-stranded RNA formation [0.03%]
反义长非编码RNA的隐秘力量——双链RNA介导的新调控层次探究
Jan-Philipp Lamping,Heike Krebber
Jan-Philipp Lamping
Over the past decade, non-coding RNAs (ncRNAs) have gained prominence in research due to their widespread presence in cells, yet their functions remain increasingly complex and less understood. Despite being initially deemed "junk," many ln...