Evaluating Malat1-derived 3'end sequences for functional transgene expression in human cells using synthetic mRNA delivery [0.03%]
利用合成mRNA递送评估Malat1衍生的3'端序列在人类细胞中的功能转基因表达
Julia Rosemann,Gwendolin Thordis Jahr,Jana Macho et al.
Julia Rosemann et al.
The poly(A) tail is a key structural element found in almost all mammalian messenger RNAs, required for stabilizing the transcript and enhancing translation. Here, we evaluate poly(A) replacement strategies based on sequence elements derive...
The mRNA architecture of the translation termination site primes programmed stop codon readthrough events in Drosophila [0.03%]
翻译终止位点的mRNA结构促使果蝇程序化停止密码子读穿事件发生
Laveena Kansara,Georg Wolfstetter,Daniel Wintermayr et al.
Laveena Kansara et al.
Programmed stop codon readthrough (SCR) is a form of genetic re-coding, in which a near-cognate tRNA base-pairs with a stop codon, leading to the translation of a C-terminally extended protein. Recent studies revealed that SCR represents an...
PrfH accelerates repair of colicin E3 - damaged translating ribosomes by RtcB2 [0.03%]
PrfH通过RtcB2促进Colicin E3损伤的翻译核糖体的修复
Tinashe P Maviza,Nadezhda R Burmistrova,Aleksandr A Grachev et al.
Tinashe P Maviza et al.
Colicin E3 (E3-rRNAse) abolishes protein biosynthesis in bacteria by cleaving 16S rRNA in the decoding centre. The RtcB2-PrfH 16S rRNA repair module prevents cellular death upon exposure to E3-rRNAse in E. coli. Upon overexpression, RtcB2 R...
Structure-driven function of plant lncRNAs: conserved RNA architectures in transcriptional and post-transcriptional regulation [0.03%]
植物长链非编码RNA的结构驱动功能：转录和后转录调控中保守的RNA架构
Yanqi Shen,Qianli Dong,Yiliang Ding et al.
Yanqi Shen et al.
Long noncoding RNAs (lncRNAs) have emerged as critical regulators of plant development, physiology, and environmental stress adaptation. Despite exhibiting limited primary sequence conservation across the plant kingdom, emerging evidence un...
Integrating bulk and single-cell transcriptomic data to construct a risk model for histidine metabolism-related epithelial cell features in lung adenocarcinoma, predicting prognosis and immune landscape [0.03%]
整合批量和单细胞转录组数据构建组氨酸代谢相关上皮细胞特征的肺腺癌风险模型，预测预后和免疫图谱
Chaofan Mao,Lin Zhou
Chaofan Mao
The rising incidence and mortality of lung adenocarcinoma (LUAD) present a significant public health challenge. Histidine, an essential amino acid, plays a pivotal role in metabolic processes, yet its specific contribution to LUAD pathogene...
RNA G-quadruplex-protein interactions: from nuclear RNA processing to cytoplasmic stress response and neurodegeneration [0.03%]
RNA G-四链体与蛋白质相互作用：从核内RNA加工到胞浆应激反应和神经退行性疾病
Dimitrios G Anastasakis,Markus Hafner
Dimitrios G Anastasakis
RNA G-quadruplexes (rG4s) are stable secondary structures formed by non-canonical Hoogsteen base-pairing of guanine-rich sequences in precursor and mature messenger and non-coding RNAs. We review evidence that rG4s exist in two functionally...
Toward precision oncology: deciphering the circRNA-EMT axis in cancer and its therapeutic implications [0.03%]
精准肿瘤学：揭秘环状rna-上皮间质转化在癌症中的作用及其治疗意义
Zekai Lv,Guang Xie,Wenming Xu
Zekai Lv
The epithelial-mesenchymal transition is a pivotal driver of cancer metastasis, the leading cause of mortality in solid tumours. Circular RNAs, a unique class of endogenous RNAs characterized by covalently closed loop structures and high st...
RNA export through the nuclear pore complex: pathways, mechanisms, and imaging strategies [0.03%]
核孔复合物介导的RNA输出：途径、机制与成像策略
Donghong Fu,Wenlan Yu,Fanghemei Zhang et al.
Donghong Fu et al.
Understanding how RNA molecules traverse the nuclear pore complex (NPC) is central to regulated gene expression because the NPC serves as the selective gateway for RNA export from the nucleus. Distinct RNA classes, including tRNAs, snRNAs, ...
NSUN2 as an emerging epigenetic regulator in cancer: from biomarker to therapeutic target [0.03%]
NSUN2作为癌症中的新型表观遗传调控因子：从生物标志物到治疗靶点
Yukun Wei,Wenjian Xu,Yueyang Bi et al.
Yukun Wei et al.
NOL1/NOP2/SUN domain family member 2 (NSUN2), a member of the RNA methyltransferase family responsible for catalysing 5-methylcytosine (m5 C) modifications, has been increasingly recognized as a key regulatory factor in the initiation and p...
Crosstalk between RNA secondary and three-dimensional structure prediction: a comprehensive study [0.03%]
RNA二级结构与三维结构预测相互作用的全面研究
Deyin Wang,Yangwei Jiang,Linli He et al.
Deyin Wang et al.
In recent years, various computational methods have been developed to predict the three-dimensional (3D) structures of RNAs. Due to its hierarchical folding property, RNA secondary (2D) structure is often used as input for 3D structure pred...