Coordination of the Fe-S cluster biogenesis network by the sRNA RyhB in E. coli [0.03%]
RyhB-siRNA通过铁调控细菌Fe-S簇生物发生成网协调
Karine Prévost,Carlos Daniel Vega Valle,Marie-Hélène Normand et al.
Karine Prévost et al.
Iron (Fe) plays critical roles as enzyme cofactor involved in key biological processes but can also lead to toxicity by catalysing the formation of highly damaging reactive oxygen species. To stabilize Fe and perform catalysis, most organis...
Precursor RNA structural patterns at SF3B1 mutation sensitive cryptic 3' splice sites [0.03%]
SF3B1突变敏感的隐蔽外显子多聚嘧啶序列的前体RNA结构特征分析
Austin Herbert,Abigail Hatfield,Alexandra Randazza et al.
Austin Herbert et al.
SF3B1 is a core component of the spliceosome involved in branch point recognition and 3' splice site selection. The SF3B1 K700E mutation, (lysine to glutamic acid), is common in myelodysplastic syndrome and other blood disorders. SF3B1 K700...
DeepRNA-Reg: a deep-learning based approach for comparative analysis of CLIP experiments [0.03%]
基于深度学习的CLIP实验比较分析方法DeepRNA-Reg
Harshaan Sekhon,Robin Kageyama,Neil T Sprenkle et al.
Harshaan Sekhon et al.
DeepRNA-Reg employs advances in deep learning to enable high-fidelity comparative analysis of paired datasets of high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP). In a HITS-CLIP experimental paradig...
Comparative Study
RNA biology. 2025 Dec;22(1):1-18. DOI:10.1080/15476286.2025.2564941 2025
Altering rRNA 2'O-methylation pattern during neuronal differentiation is regulated by FMRP [0.03%]
FMRP调控神经元分化过程中rRNA 2'-O-甲基化模式的重编程
Michelle Ninochka D&#x;Souza,Naveen Kumar Chandappa Gowda,Nivedita Hariharan et al.
Michelle Ninochka D&#x;Souza et al.
The Fragile X Messenger Ribonucleoprotein (FMRP) is a selective RNA-binding protein that localizes to the cytoplasm and the nucleus. The loss of FMRP results in Fragile X Syndrome (FXS), an autism spectrum disorder. FMRP interacts with ribo...
miR-4484 suppresses hepatocellular carcinoma progression via targeting KIF2C [0.03%]
microRNA-4484通过靶向KIF2C抑制肝癌进展
Jianyang Lin,Yun Cai,Zhihong Chen et al.
Jianyang Lin et al.
Aberrantly expressed microRNA-4484 (miR-4484) has recently garnered attention for its involvement in human diseases, but its specific role in hepatocellular carcinoma (HCC) remains largely unexplored. This study investigates the function of...
E2-regulated transcriptome complexity revealed by long-read direct RNA sequencing: from isoform discovery to truncated proteins [0.03%]
利用长读直接RNA测序揭示E2调控的转录组复杂性：从异构体发现到截断蛋白
Didem Naz Dioken,Ibrahim Ozgul,Irem Yilmazbilek et al.
Didem Naz Dioken et al.
Oestrogen receptor alpha (ERα)-positive (ER+) breast cancers are driven by the binding of 17β-oestradiol (E2) to ERα, which transcriptionally regulates target genes. Although microarrays and conventional RNA sequencing have identified E2...
MicroRNA-mediated regulation of proliferation, lineage differentiation, and apoptosis in neural stem cells [0.03%]
微小核糖核酸调控神经干细胞增殖、分型及凋亡的作用机制研究
Yukyeong Lee,Camilla Boschian,Kinarm Ko
Yukyeong Lee
Neural stem cells (NSCs) are multipotent stem cells with self-renewal capacity, able to differentiate into all neural lineages of the central nervous system, including neurons, oligodendrocytes, and astrocytes; thus, their proliferation and...
Direct and indirect effects of spliceosome disruption compromise gene regulation by nonsense-mediated mRNA decay [0.03%]
裂解体功能紊乱的直接和间接效应损害由无意义介导的mRNA降解对基因的调控作用
Caleb M Embree,Debadrita Paul,Andreas Stephanou et al.
Caleb M Embree et al.
Pre-mRNA splicing, carried out in the nucleus by a large ribonucleoprotein machine known as the spliceosome, is functionally and physically coupled to the mRNA surveillance pathway in the cytoplasm called nonsense-mediated mRNA decay (NMD)....
Time-resolved miRNA-mRNA integrated analysis reveals the miRNA-mRNA networks underlying plasma membrane damage-dependent senescence and DNA damage response-dependent senescence in WI-38 normal human fibroblasts [0.03%]
时间分辨的miRNA-mRNA整合分析揭示了与WI-38人正常成纤维细胞的质膜损伤依赖性衰老和DNA损伤应答依赖性衰老相关的miRNA-mRNA网络
Yatzu Chiu,Risa Ishida,Yohsuke Moriyama et al.
Yatzu Chiu et al.
Cellular senescence is a stable cell cycle arrest associated with upregulated inflammatory responses. Senescent cells contribute to various pathological and physiological processes including organismal ageing and cancer. Cellular senescence...
Opposing mechanisms by which miRNAs mediate distinct Nrf1 and Nrf2 regulation of epithelial-mesenchymal transition in hepatocellular carcinoma [0.03%]
调控肝癌上皮间质转化的Nrf1和Nrf2的不同miRNA介导机制
Juan Chen,Jing Feng,Yuping Zhu et al.
Juan Chen et al.
Accumulation of various genetics and epigenetics alterations are accepted to result in the initiation and progression of hepatocellular carcinoma (HCC), and its high metastasis is viewed as a critical bottleneck leading to its treatment fai...