Translational repression of 5' TOP mRNAs in chronically activated CD8+ T cells in vitro [0.03%]
体外慢性活化的CD8⁺T细胞中对5'TOP mRNA的翻译抑制作用
Erica S Pledger,Navya Ambavaram,Lucas Ferguson et al.
Erica S Pledger et al.
T cell exhaustion is a dysfunctional state that arises during chronic infections and cancer, characterized by impaired effector functions and sustained expression of inhibitory receptors. While transcriptional, epigenetic, and metabolic rew...
Phani Rama Krishna Behra,Malavika Ramesh,B M Fredrik Pettersson et al.
Phani Rama Krishna Behra et al.
The Mycobacterium genus includes more than 190 species that occupies diverse ecological niches. Some are non-pathogenic and environmental, whereas others cause severe diseases both in humans and animals, e.g. tuberculosis (TB) and leprosy. ...
Yenan Yang,Yuanming Zheng,Qiang Zhou et al.
Yenan Yang et al.
The Mediator complex functions as a central multi-subunit coactivator essential for RNA polymerase II-dependent transcription in eukaryotes, integrating signals from enhancers to promoters across the transcription cycle. This review summari...
TWO DIPEPTIDE REPEAT PROTEINS ARE PRODUCED FROM MAMMALIAN TELOMERIC RNA PREVIOUSLY THOUGHT TO BE a LONG NON-CODING RNA [0.03%]
此前被认为是一种长链非编码RNA的哺乳动物端粒RNA可产生两种二肽重复蛋白
Taghreed M Al-Turki,Jack D Griffith
Taghreed M Al-Turki
Studies of neurological diseases caused by the expansion of nucleotide repeats led to the discovery that RNA can undergo translation by ribosomes in the absence of canonical AUG start signals, a process termed repeat-associated non-ATG tran...
miR-181a-5p: a key regulator of placental function in health and disease [0.03%]
miR-181a-5p：健康与疾病状况下胎盘功能的关键调节因子
Leisa Lopes-Aguiar,Rafaella Scandiuzzi,Gabriela Michelazzo et al.
Leisa Lopes-Aguiar et al.
MicroRNAs (miRNAs) are essential post-transcriptional regulators implicated in diverse physiological and pathological processes. Recently, miR-181a-5p emerged as a critical modulator of placental function. This review synthesizes literature...
Sameer Singh,Denis L J Lafontaine
Sameer Singh
Ribosomes are essential nanomachines responsible for synthesizing all cellular proteins. Their production, known as ribosome biogenesis, is a highly complex and energy-intensive process that requires the coordinated action of hundreds of pr...
Alpha-like subunits of multisubunit RNA polymerases: insights into structure, function, and disease [0.03%]
多亚基RNA聚合酶的alpha样亚基：结构、功能及与疾病的关系透视
Onyinyechi C Onuoha,Alana E Belkevich,Ryan J Palumbo et al.
Onyinyechi C Onuoha et al.
Multisubunit RNA polymerases share a deeply conserved architectural core, yet their regulatory complexity has expanded dramatically over evolution. At the heart of this architecture lies an ancient assembly module formed by the alpha and al...
RNA polymerase II phosphorylation dynamics: from molecular mechanisms to human disease [0.03%]
RNA聚合酶II磷酸化动力学：从分子机制到人类疾病
Araceli González-Jiménez,Ithaisa Medina,Manuel J Alfonso et al.
Araceli González-Jiménez et al.
Accurate RNA polymerase II (RNAPII)-dependent gene expression requires dynamic phosphorylation of the carboxy-terminal domain (CTD) of its largest subunit, Rpb1, whose heptapeptide repeats form a regulatory platform known as the CTD code. T...
Impact of interspecies colostrum and milk replacement on circulating sncRNA dynamics of neonatal goat kids [0.03%]
异种初乳和牛奶替代对山羊 Kids新生期循环sncrna动态的影响
Rob J Dekker,Marielle H van den Esker,Lars Ravesloot et al.
Rob J Dekker et al.
Replacing maternal colostrum and milk with those from other species is common practice in neonatal ruminant management, but the effects on small non-coding RNA (sncRNA) transmission remain poorly understood. This study investigated whether ...
Merin Joy,Alice Cleynen,Nikolay E Shirokikh
Merin Joy
RNA modifications have emerged as central regulators of cancer translational control. Unlike transcriptional reprogramming, which unfolds over hours, modification-dependent translational rewiring enables rapid proteomic adaptation to the nu...