Sameer Singh,Denis L J Lafontaine
Sameer Singh
Ribosomes are essential nanomachines responsible for synthesizing all cellular proteins. Their production, known as ribosome biogenesis, is a highly complex and energy-intensive process that requires the coordinated action of hundreds of pr...
Alpha-like subunits of multisubunit RNA polymerases: insights into structure, function, and disease [0.03%]
多亚基RNA聚合酶的alpha样亚基：结构、功能及与疾病的关系透视
Onyinyechi C Onuoha,Alana E Belkevich,Ryan J Palumbo et al.
Onyinyechi C Onuoha et al.
Multisubunit RNA polymerases share a deeply conserved architectural core, yet their regulatory complexity has expanded dramatically over evolution. At the heart of this architecture lies an ancient assembly module formed by the alpha and al...
RNA polymerase II phosphorylation dynamics: from molecular mechanisms to human disease [0.03%]
RNA聚合酶II磷酸化动力学：从分子机制到人类疾病
Araceli González-Jiménez,Ithaisa Medina,Manuel J Alfonso et al.
Araceli González-Jiménez et al.
Accurate RNA polymerase II (RNAPII)-dependent gene expression requires dynamic phosphorylation of the carboxy-terminal domain (CTD) of its largest subunit, Rpb1, whose heptapeptide repeats form a regulatory platform known as the CTD code. T...
Impact of interspecies colostrum and milk replacement on circulating sncRNA dynamics of neonatal goat kids [0.03%]
异种初乳和牛奶替代对山羊 Kids新生期循环sncrna动态的影响
Rob J Dekker,Marielle H van den Esker,Lars Ravesloot et al.
Rob J Dekker et al.
Replacing maternal colostrum and milk with those from other species is common practice in neonatal ruminant management, but the effects on small non-coding RNA (sncRNA) transmission remain poorly understood. This study investigated whether ...
Merin Joy,Alice Cleynen,Nikolay E Shirokikh
Merin Joy
RNA modifications have emerged as central regulators of cancer translational control. Unlike transcriptional reprogramming, which unfolds over hours, modification-dependent translational rewiring enables rapid proteomic adaptation to the nu...
Discovery of a mutation-containing circRNA in polyglutamine disease through systematic analysis of RNAs with CAG repeats [0.03%]
通过分析含有CAG重复的RNA系统发现多谷氨酰胺病相关的环状RNA变异体
Weronika Pawlik,Magdalena Woźna-Wysocka,Magdalena Jazurek-Ciesiołka et al.
Weronika Pawlik et al.
CAG repeat tracts occur in both non-coding and translated RNAs, have tended to lengthen throughout evolution, and are thought to enhance neuronal function. We identified over 600 human RNAs (including mRNAs, lncRNAs, and circRNAs) with at l...
FDA-approved antisense oligonucleotide therapies for duchenne muscular dystrophy: current status and future outlook [0.03%]
杜氏肌营养不良症的反义寡核苷酸疗法现状及未来展望
Hidenori Moriyama,Shiori Moriyama,Toshifumi Yokota
Hidenori Moriyama
Duchenne muscular dystrophy (DMD) is a fatal X-linked recessive disorder caused by dystrophin deficiency. Antisense oligonucleotide (ASO)-mediated exon skipping has emerged as a cornerstone of DMD therapy to restore dystrophin expression. T...
The RNA binding protein ZFP36L2 displays tissue-selective mRNA targeting in mice [0.03%]
RNA结合蛋白ZFP36L2在小鼠组织中表现出选择性的mRNA靶向性
George Stephen Stephenson,Dalia Fleifel,Jeanette Gowen Cook et al.
George Stephen Stephenson et al.
ZFP36L2 (zinc finger protein 36 like 2, C3H type-ZFP) is an RNA-binding protein targeting transcripts rich in adenine-uridine elements (AREs). Previous transcriptomic analysis suggested that ZFP36L2 displays a distinct transcript preference...
Biological consequences of Z-Nucleic acid sensing by ZBP1 and ADAR1 [0.03%]
ZBP1和ADAR1感应Z-型核糖核酸的生物学效应
Fei Lu,Linghuan Tang,Chun Kim et al.
Fei Lu et al.
Since their discovery, Z-nucleic acids (Z-NAs), which adopt a left-handed double helical conformation, have puzzled researchers regarding their physiological functions. These unusual nucleic acids are recognized by proteins containing Zα d...
Crosstalk between circRNAs and the classic signaling pathways in IBD [0.03%]
Circular RNA与经典信号通路在IBD中的串扰机制探究
Mengmeng Jie,Qiushi Liao,Cheng Liu
Mengmeng Jie
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disorder of the gastrointestinal tract with a complex aetiology involving genetic, environmental (such as diet/life...