Cas10 residues lining the target RNA binding channel regulate interference by distinguishing cognate target RNA from mismatched targets [0.03%]
调节干扰通过区分同源目标RNA和不匹配的目标RNA来调控Cas10中定位靶RNA结合通道的残基
Sarah Khweis,Mason Blackburn,Calvin Perdigao et al.
Sarah Khweis et al.
Type III CRISPR systems are defined by the presence of the Cas10 protein and are among the most abundant CRISPR systems in nature. Cas10 forms a complex with crRNA and several Cas proteins that surveils prokaryotic cells for foreign RNA mol...
A transformer based method for the Cap analysis of gene expression and gene expression tag associated capping region prediction in RNA [0.03%]
一种基于变压器的用于基因表达Cap分析和基因表达标签相关加帽区域预测的方法
Dibya Kanti Haldar,Avik Pramanick,Chandrama Mukherjee et al.
Dibya Kanti Haldar et al.
5' RNA capping is one of the major post-transcriptional modifications for the mobility and stability of RNA molecules. Measuring 5' caps of RNAs can help quantify expression levels of mRNAs and lncRNAs. One of the most successful RNAseq met...
Profound alterations of cancer transcriptomes by the RNase L inhibitor ABCE1 through the modulation of UU/UA-dinucleotide rich transcript abundance [0.03%]
ABCE1通过调节UU/UA-二核苷酸丰富转录本的丰度对癌症转录组产生深远的影响
Edward Hitti,Tala Bakheet,Linah Mahmoud et al.
Edward Hitti et al.
Tumorigenesis is commonly driven by genetic mutations and disruptions in cellular signalling pathways. Here we show that the oncogenic overexpression of the RNase L inhibitor ABCE1, a component of interferon signalling, leads to distinct an...
Crystal Ling,Benjamin Lebeau,Kwoh Chee Keong et al.
Crystal Ling et al.
The epitranscriptome comprises chemical modifications found on RNA molecules that play essential roles in co- and post-transcriptional gene regulation. Dysregulation of these modifications has been implicated in various diseases, fuelling i...
Mechanistic studies on HNRNPA2B1 suggest binding but not selective recognition of m6A [0.03%]
关于HNRNPA2B1的机制研究表明其与m6A的结合但并非选择性识别
Raeyeon Park,Madeline Demny,Lucas G Miller et al.
Raeyeon Park et al.
HNRNPA2B1 contains two RRM domains and has been investigated for its possible role as an m6A reader protein. The targetome of HNRNPA2B1 was shown to overlap with the m6A methylation motif, but further investigations of its binding affinity ...
Non-coding small RNAs Buffer protein interactions to prevent oncogenic aggregation: structural dampening of aberrant PPIs by RNA [0.03%]
非编码小RNA通过缓冲蛋白质相互作用来防止致癌聚集：由RNA对异常PPIs的结构阻尼作用
Masanobu Chinami
Masanobu Chinami
Non-coding RNAs (ncRNAs) modulate protein - protein interactions (PPIs) by shaping the structural context in which binding occurs, rather than acting as direct inhibitors or enhancers. Using an integrative framework combining catRAPID RNA -...
Marianne Régis,Paola Pulcina,Dmitry Kretov
Marianne Régis
RNA-binding proteins (RBPs) constitute a diverse class of proteins essential for every stage of gene expression process. Many RBPs are also linked to human diseases and pathologies. Understanding the molecular grammar of RNA-protein interac...
RGG-motif protein Scd6 affects oxidative stress response by regulating cytosolic caTalase T1 (Ctt1) [0.03%]
RGG框蛋白Scd6通过调节细胞质催化酶Ctt1影响氧化压力响应
Sweta Tiwari,Chitra Togra,Sudharshan Sj et al.
Sweta Tiwari et al.
In response to stress, cells undergo gene expression reprogramming to cope with external stimuli. Cells utilize a conserved stress response mechanism called global downregulation of translation, leading to the storage of translationally rep...
Conversations at the crossroads of the Human RNome project: a collaborative reflection by the RNome early career Researcher (ECR) [0.03%]
人类基因组计划交叉口的对话：RNome早期职业研究人员（ECR）的合作反思
Bennett Henzeler,Rebekah Penrice-Randal,Rami Bechara et al.
Bennett Henzeler et al.
Different MicroRNAs expression in Mycobacterium tuberculosis and correlation with prognosis of the disease [0.03%]
不同分枝杆菌感染的microRNA表达差异及其与结核病预后的相关性研究
Karthikeyan Sundaram,Sridhar Rathinam
Karthikeyan Sundaram
Tuberculosis, caused by Mycobacterium tuberculosis, is an infectious disease linked to high mortality and can stay in the host cell longer when inactive. Multiple factors are linked to disease prognosis, including microRNAs. It is a diminut...