Systematic analysis of A-to-I RNA editing upon release of ADAR from the nucleolus [0.03%]
ADAR解离至核仁后A-to-I RNA编辑的系统分析
Ruben Lattuca,Rümeyza Bascetin,Vincent Detours et al.
Ruben Lattuca et al.
Adenosine-to-inosine (A-to-I) RNA editing, catalysed by two ADAR isoforms (p110 and p150) and ADARB1, is a critical regulatory step in gene expression. Intriguingly, the nucleolus is conspicuously rich in ADAR p110 and ADARB1, though the bi...
Investigation of possible G-quadruplex formation by GU- and GA-rich repeats and their role in translation [0.03%]
富含GU和GA重复序列的G-四链体形成的可能及其在翻译中的作用研究
Bas M Morren,Jitske Marcelis,Iza Muradin et al.
Bas M Morren et al.
RNA G-quadruplexes (rG4s) are involved in many aspects of cellular and viral protein expression. rG4s consist of at least two stacks of guanine tetrads that are stabilized by non-Watson-Crick-Franklin base pairs. It is currently unknown how...
Extracellular vesicle-derived MicroRNAs as potential therapies for spinal cord and peripheral nerve injuries [0.03%]
外泌体衍生的微小RNA作为脊髓和周围神经损伤潜在治疗手段的可能性
Young-Ju Lim,Min-Soo Seo,Wook-Tae Park et al.
Young-Ju Lim et al.
Complete nerve regeneration is limited in current therapeutic approaches for spinal cord injuries (SCIs) and peripheral nerve injuries (PNIs). Extracellular vesicles (EVs) and microRNAs (miRNAs) play a pivotal role in intercellular communic...
Deciphering the multifaceted role of double-stranded RNA sensor protein kinase R: pathophysiological function beyond the antiviral response [0.03%]
解码双链RNA传感器蛋白激酶R的多面角色：超越抗病毒反应的病理生理功能
Jiyoon Chung,Yerim Lee,Jimin Yoon et al.
Jiyoon Chung et al.
Protein kinase R (PKR) is a serine/threonine kinase that recognizes double-stranded RNAs (dsRNAs) to initiate innate immune signalling during viral infection. PKR dimerizes on long dsRNAs and undergoes autophosphorylation. Phosphorylated/Ac...
Dual synthesis pathways of scaRNA28 via intronic processing of transformation/transcription domain-associated protein transcripts and a novel independent transcription unit [0.03%]
转化/转录域相关蛋白转录本和新型独立转录单位的内含子加工生成scaRNA28的双重合成途径
Keiichi Izumikawa,Tatsuya Shida,Hideaki Ishikawa et al.
Keiichi Izumikawa et al.
Small Cajal body-specific RNAs (scaRNAs) are noncoding RNAs involved in the maturation of U-rich small nuclear RNAs. Except for a few that have their own transcription units, most scaRNA genes are embedded in introns and are predicted to be...
RNA-seq analyses reveal the relevance of RNAs involved in ribosomal complex to induce mammalian prion protein aggregation and phase separation in vitro [0.03%]
RNA_seq分析揭示了与诱导哺乳动物朊蛋白体外聚集和相分离相关的核糖体复合物相关RNAs的相关性
Ana C Tahira,Mariana P B Gomes,Maria Heloisa Freire et al.
Ana C Tahira et al.
Conformational conversion of cellular prion protein (PrPC) into infectious PrP (PrPSc) is one of the most intriguing processes in modern Biology. It is well accepted that this transition is catalysed by one or more cofactors that lower the ...
The oncogenic microRNA miR-222 promotes human LINE-1 retrotransposition [0.03%]
致癌性microRNA miR-222促进人类LINE-1逆转录拷贝的增加
Tomer Friehmann,Yamama Abu Mohsen,Yehuda Schlesinger et al.
Tomer Friehmann et al.
The Long Interspersed Element-1 (LINE-1) contributes significantly to carcinogenesis and to tumour heterogeneity in many cancer types, including hepatocellular carcinoma (HCC), by its autonomous retrotransposition (RTP) and by its ability t...
Computational limitations and future needs to unravel the full potential of 2'-O-Methylation and C/D box snoRNAs [0.03%]
计算限制和未来需求以充分挖掘2'-O-甲基化和C/D盒snoRNA的潜力
Christian Ramirez,Elena Perenthaler,Fabio Lauria et al.
Christian Ramirez et al.
This review evaluates the current state of C/D snoRNA databases and prediction tools in relation to 2'-O-methylation (2'-O-Me). It highlights the limitations of existing resources in accurately annotating and predicting guide snoRNAs, parti...
Leslie Watkins,Mulin Li,Bin Wu
Leslie Watkins
Translation converts genetic information in mRNAs into functional proteins. This process occurs in four major steps: initiation, elongation, termination and ribosome recycling; each of which profoundly impacts mRNA stability and protein yie...
John V McGuire,Scott Horowitz
John V McGuire
Nsp15 is an EndoU nuclease that is partially responsible for SARS-CoV-2's ability to evade the immune system response. Despite its importance, the sequence specificity of Nsp15 remains difficult to fully determine. In this work, we use a sy...