The RNA-binding activity of the drosophila Brat protein is necessary for viability and mRNA regulation [0.03%]
果蝇Brat蛋白的RNA结合活性对其存活及mRNA调节是必不可少的
Robert Connacher,Yichao Hu,Richard Roden et al.
Robert Connacher et al.
Brain tumour (Brat) is a Drosophila TRIM-NHL protein required for embryogenesis and neural stem cell differentiation. Although structural and biochemical studies established that the Brat NHL domain specifically binds RNA, the in vivo requi...
The role of miRNA in modulating oxidative stress in preeclampsia: current knowledge [0.03%]
miRNA在调节子痫前期氧化应激中的作用：现状及展望
Chao Lin,Qiang Xu,Jinye Yan et al.
Chao Lin et al.
Preeclampsia (PE), a gestational disorder diagnosed with hypertension and proteinuria, is recognized as a significant cause of both maternal and perinatal morbidity and mortality around the world. Oxidative stress (OS) is found to act as a ...
Ann S Yang,Alexander M Tang,Mary Gehring
Ann S Yang
Plants possess an expansive suite of epigenetic control mechanisms to keep their large, repetitive, and unruly genomes in check. Small non-coding RNAs constitute one such mechanism by directing transcriptional and post-transcriptional gene ...
miR-34 regulates cuticle pigmentation by targeting Bm-iAANAT and Bmserpin3 in Bombyx mori [0.03%]
微RNA-miR-34通过靶向蚕眼斑素和丝胶蛋白家族蛋白成员调控家蚕茧色遗传分子机制研究
Zulian Liu,Dehong Yang,Xingyu Luo et al.
Zulian Liu et al.
Pigmentation is an orchestrated process involved in cuticle melanization and sclerotization in insects, and plays a critical role in maintaining the structural integrity and functional completeness of the insect cuticle. Although the cascad...
Identification of proteins interacting with the N-terminal half of endoribonuclease RNase E in Escherichia coli [0.03%]
鉴定参与RNase E蛋白N端区的相互作用蛋白质
Yvonne Göpel,Svetlana Durica-Mitic,Solomiia Boyko et al.
Yvonne Göpel et al.
In E. coli endoribonuclease RNase E (Rne) plays a central role in RNA processing and decay. Rne consists of an N-terminal catalytic domain (NTD) and a C-terminal scaffolding domain, separated by a membrane targeting sequence (MTS). While th...
Julie Buisson,Florent Colin,Anna Labernadie et al.
Julie Buisson et al.
Chromatin serves as the dynamic carrier of genetic and epigenetic information in eukaryotic cells, playing a pivotal role in maintaining nuclear shape, mechanical stability, and cellular function. Aberrant nuclear morphology, often observed...
Nusinersen: the antisense oligonucleotide at the forefront of spinal muscular atrophy treatment [0.03%]
用于治疗脊髓性肌萎缩症的反义寡核苷酸药物诺西那生钠注射液
Natalia N Singh,Eric W Ottesen,Ravindra N Singh
Natalia N Singh
Spinal muscular atrophy (SMA) is the first human disease to be treated with an antisense oligonucleotide (ASO) that restores the full coding sequence of a mRNA through splicing modulation. The therapeutic ASO nusinersen (marketed as Spinraz...
Comprehensive profiling and molecular characterization of alternative splicing regulation in synaptic remodeling associated with neuropathic pain induced by chronic constrictive injury in a rat Model [0.03%]
慢性 constriction性损伤诱发的大鼠神经病理性疼痛相关突触重塑的可变剪接调控的全面谱型及分子特征分析
Jun Zhou,Yifan Jia,Wei Song et al.
Jun Zhou et al.
Background: Neuropathic pain (NP) is a chronic pain condition caused by injury to the nervous system. Although alternative splicing dysregulation has been implicated in NP, the contribution of RNA-binding proteins (RBPs) ...
Bevacizumab induces apoptosis in glioblastoma cells by upregulating miR-4695-5p to inhibit PKMYT1 [0.03%]
贝伐单抗通过上调miR-4695-5p抑制PKMYT1诱导胶质母细胞瘤细胞凋亡
Yuan Shen,Chong Yang,Huayin Wang et al.
Yuan Shen et al.
We sought to determine the pro-apoptotic effects of bevacizumab in glioblastoma (GBM) and to elucidate the contribution of the miR-4695-5p/PKMYT1 pathway to this process. Following treatment of U87MG and U251 GBM cells with dose-gradient be...
The lncRNA ZNF295-AS1 alleviates lung squamous cell carcinoma progression by reducing miR-96-5p and inhibiting cancer cell invasiveness [0.03%]
长链非编码RNA ZNF295-AS1通过降低miR-96-5p和抑制癌细胞侵袭性来缓解肺鳞状细胞癌的进展
Yan Huang,Dong Yan,Zhenhua Hao et al.
Yan Huang et al.
Objective: Lung squamous cell carcinoma (LUSC) is highly invasive, and patients with advanced disease generally have a poor prognosis. ZNF295-AS1 is abnormally expressed in lung cancer. This study aims to investigate the ...