Functional validation of somatic variability in TP53 and KRAS for prediction of platinum sensitivity and prognosis in epithelial ovarian carcinoma patients [0.03%]
用于预测上皮性卵巢癌患者铂敏感性和预后的TP53和KRAS体细胞变异的功能验证
Al Obeed Allah Mohammad,Ali Esraa,Krus Ivona et al.
Al Obeed Allah Mohammad et al.
Concerning the dismal prognosis of chemoresistant patients with epithelial ovarian carcinoma (EOC), we aimed to follow up the findings of a previous whole-exome sequencing study using an orthogonal Sanger sequencing on the same patients and...
Unraveling the dual role of METTL3-mediated m6A RNA modification in bladder cancer: mechanisms, therapeutic vulnerabilities, and clinical implications [0.03%]
膀胱癌中METTL3介导的m6A修饰的双刃剑作用：机制、治疗靶点及临床意义
Hua Chun,Kangzhuo Baima
Hua Chun
Bladder cancer (BC) remains challenging due to its recurrence and metastasis, with METTL3-mediated m6 A RNA modification emerging as a key oncogenic driver. This review synthesizes METTL3's roles in BC progression, including tumor initiatio...
NR4A3 regulates anoikis resistance and metastasis of bladder cancer through EWSR1 [0.03%]
NR4A3通过EWSR1调节膀胱癌的悬浮耐受性和转移性
Li Fan,Yulin Zhou,Shouyong Liu et al.
Li Fan et al.
Bladder cancer (BLCA) is a common urinary malignancy with high metastatic potential. However, the mechanisms underlying its progression remain unclear. This study aimed to investigate the role and regulatory mechanisms of NR4A3, a nuclear r...
Dual role of CXCL10 in cancer progression: implications for immunotherapy and targeted treatment [0.03%]
CXCL10在癌症进展中的双重作用：对免疫治疗和靶向治疗的意义
Osama A Madkhali,Sivakumar S Moni,Yosif Almoshari et al.
Osama A Madkhali et al.
CXCL10 is a chemokine crucial for immune cell recruitment and inflammation modulation, especially within the tumor microenvironment. This review critically analyzes the underexplored role of CXCL10 in modulating JAK/STAT, MAPK/ERK, an...
Advancements in exosome-based cancer diagnosis: from chipsets to nano vaccine [0.03%]
基于外泌体的癌症诊断进展：从芯片到纳米疫苗
Nobendu Mukerjee,Subham Sarkar,Daniel Ejim Uti et al.
Nobendu Mukerjee et al.
Exosome-based therapies represent a pioneering frontier in cancer treatment, leveraging the natural cellular communication mechanisms encapsulated in exosomes. These nano-sized vesicles serve as carriers of proteins, lipids, and nucleic aci...
A comparison of cell death pathways in three different kinds of human lung cancer cell lines following hematoporphyrin derivative-mediated photodynamic therapy [0.03%]
血卟啉衍生物介导的光动力学治疗后三种不同人肺癌细胞株凋亡途径的研究比较分析
Yijiang Ma,Baohong Xiao,Aihua Sui et al.
Yijiang Ma et al.
This study was conducted to investigate the in vitro differences in killing effects and cellular death pathways in human bronchial epithelial BEAS-2B cells, human lung adenocarcinoma A549 cells, human lung squamous carcinoma H520 cells, and...
Cooperative CCL2/CCR2 and HGF/MET signaling enhances breast cancer growth and invasion associated with metabolic reprogramming [0.03%]
CCL2/CCR2和HGF/MET信号协作通过代谢重编程序增强乳腺癌的生长和侵袭性
Wei Fang,Yuuka Kozai,Diana S Acevedo et al.
Wei Fang et al.
With over 60,000 cases diagnosed in women annually, ductal carcinoma in situ (DCIS) is the most common form of pre-invasive breast cancer in the US. Despite standardized therapy, under-treatment and over-treatment are prevailing concerns. B...
Copper death combination therapy: the innovative frontier and challenges in prostate cancer treatment [0.03%]
铜死亡联合治疗：前列腺癌治疗的新前沿与挑战
Jia Wei He,Pei Zhen Li,Zi Xuan Huang
Jia Wei He
Prostate cancer (PCA) remains a significant health challenge, necessitating the exploration of novel therapeutic strategies to enhance patient outcomes. Recent research has identified cuproptosis, a copper-dependent programmed cell death me...
Lenvatinib promotes hepatocellular carcinoma pyroptosis by regulating GSDME palmitoylation [0.03%]
仑伐替尼通过调节GSDME棕榈酰化促进肝癌细胞焦亡
Yuan Yuan,Mu-Ru Wang,Yang Ding et al.
Yuan Yuan et al.
Lenvatinib, as a multi-kinase inhibitor, has been approved as a first-line drug for patients with advanced hepatocellular carcinoma (HCC). Gasdermin E (GSDME)-mediated pyroptosis, a form of programmed cell death, can be induced by chemother...
Robust prediction of glioma prognosis by hypoxia-induced ferroptosis genes: VEGFA-XBP1 co-expression for salvage therapy [0.03%]
缺氧诱导的铁死亡基因对胶质瘤预后的稳健预测：VEGFA-XBP1共表达挽救疗法
Zhou Liwei,Lu Hanwen,Zhao Wenpeng et al.
Zhou Liwei et al.
Hypoxia as a hallmark of solid malignancies compromises therapeutic efficacy and prognosis. This study deciphers the functional role of hypoxia-induced ferroptosis in glioma prognosis. Hypoxia-related transcripts and ferroptosis markers wer...