Tumor microenvironment in primary central nervous system lymphoma (PCNSL) [0.03%]
原发中枢神经系统淋巴瘤(PCNSL)的肿瘤微环境
Qiqi Jin,Haoyun Jiang,Ye Han et al.
Qiqi Jin et al.
Primary central nervous system lymphoma (PCNSL) is one of the rare lymphomas limited to the central nervous system. With the availability of immunotherapy, the tumor microenvironment (TME) attracts much attention nowadays. However, the syst...
CDH2 and CDH13 as potential prognostic and therapeutic targets for adrenocortical carcinoma [0.03%]
钙黏蛋白CDH2和CDH13可能是肾上腺皮质癌的预后及治疗靶点
Yongli Situ,Li Deng,Ziqing Huang et al.
Yongli Situ et al.
Cadherin 2 (CDH2, N-cadherin) and cadherin 13 (CDH13, T-cadherin, H-cadherin) affect the progress and prognoses of many cancers. However, their roles in adrenocortical carcinoma (ACC), a rare endocrine cancer, remain unclear. To decipher th...
SHR-1806, a robust OX40 agonist to promote T cell-mediated antitumor immunity [0.03%]
SHR-1806：一种有效的OX40激动剂，可促进T细胞介导的抗肿瘤免疫反应
Jun Zhang,Lei Zhou,Xing Sun et al.
Jun Zhang et al.
Anti-CTLA-4 and anti-PD-1/PD-L1 antibodies have significantly revolutionized cancer immunotherapy. However, the persistent challenge of low patient response rates necessitates novel approaches to overcome immune tolerance. Targeting immunos...
The tubulin polymerization inhibitor gambogenic acid induces myelodysplastic syndrome cell apoptosis through upregulation of Fas expression mediated by the NF-κB signaling pathway [0.03%]
细胞周期素依赖性激酶抑制剂 Gambogic acid 通过 NF-κB 信号通路上调Fas 表达诱导骨髓增生异常综合征细胞凋亡
Cheng Zhong,Shijun Wang,Lei Xia et al.
Cheng Zhong et al.
The development of an effective treatment for myelodysplastic syndrome (MDS) is needed due to the insufficient efficacy of current therapies. Gambogenic acid (GNA) is a xanthone constituent of gamboge, a resin secreted by Garcinia hanburyi ...
Tripartite motif-containing protein 50 suppresses triple-negative breast cancer progression by regulating the epithelial-mesenchymal transition [0.03%]
三聚体基序含有的蛋白50通过调节上皮间质转化抑制三阴性乳腺癌进展
Danxiang Chen,Jing Jiang,Wei Zhang et al.
Danxiang Chen et al.
Background and objectives: Tripartite motif-containing protein 50 (TRIM50) is a recently discovered E3 ubiquitin ligase that participates in tumor progression. TRIM50 is overexpressed in many cancers, although few studies...
A positive feedback loop of SRSF9/USP22/ZEB1 promotes the progression of ovarian cancer [0.03%]
SRSF9/USP22/ZEB1正向调控环路促进卵巢癌进展
Jing Wang,Ming Hu,Jie Min et al.
Jing Wang et al.
Ovarian cancer (OC) is recognized as the most lethal type of gynecological malignancy, making treatment options challenging. Discovering novel therapeutic targets will benefit OC patients. This study aimed to reveal the mechanism by which S...
Shujuan Jin,Mengjiao Zhang,Xiaoting Qiao
Shujuan Jin
Cyclophilin A (CypA), a member of the immunophilin family, stands out as the most prevalent among the cyclophilins found in humans. Beyond serving as the intracellular receptor for the immunosuppressive drug cyclosporine A (CsA), CypA exert...
The polymeric fluoropyrimidine CF10 overcomes limitations of 5-FU in pancreatic ductal adenocarcinoma cells through increased replication stress [0.03%]
聚氟嘧啶CF10通过增加复制压力克服了5-FU在胰腺导管腺癌细胞中的局限性
Jennifer M Finan,Roberto Di Niro,Soon Young Park et al.
Jennifer M Finan et al.
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease soon to become the second leading cause of cancer deaths in the US. Beside surgery, current therapies have narrow clinical benefits with systemic toxicities. FOLFIRINOX is the curr...
Extracellular vesicle-packaged miR-4253 secreted by cancer-associated fibroblasts facilitates cell proliferation in gastric cancer by inducing macrophage M2 polarization [0.03%]
癌相关成纤维细胞分泌的胞外囊泡包装的miR-4253通过诱导巨噬细胞M2极化促进胃癌细胞增殖
Xinxing Duan,Xiong Yu,Jin Gan
Xinxing Duan
Cancer-associated fibroblasts (CAFs) can interact with macrophages in the tumor microenvironment by secreting extracellular vesicles (EVs), thereby affecting tumor progression. However, the mechanisms of CAF-secreted EVs in gastric cancer (...
TM4SF4 is a diagnostic biomarker accelerating progression of papillary thyroid cancer via AKT pathway [0.03%]
TM4SF4通过AKT途径促进乳头状甲状腺癌进展的诊断生物标志物作用机制研究
Lizhi Lin,Jialiang Wen,Tiansheng Xu et al.
Lizhi Lin et al.
The incidence of papillary thyroid cancer (PTC) has been steadily rising, though the underlying mechanism remains unclear. This study aims to elucidate the biological role of TM4SF4 in the PTC progression. Our differential expression analys...