Molecular interplay of insulin resistance and cancer: advances in monoclonal antibody therapeutics [0.03%]
胰岛素抵抗和癌症的分子互作以及单克隆抗体治疗的进展
Sivakumar S Moni,Fatma Ayish,Shaqraa Musawi et al.
Sivakumar S Moni et al.
Insulin resistance (IR) is involved in the development, progression, and treatment resistance of cancer. Apart from contributing to obesity and type 2 diabetes, IR leads to hyperinsulinemia, disruption of insulin-like growth factor signalin...
DNA polymerase theta (Polθ): a novel candidate for targeted cancer therapy [0.03%]
DNA聚合酶胸腺嘧啶二聚体糖基化酶(Polθ)：一种潜在的癌症治疗靶点
Bo Zhou,Zhixin Wang,Jun Qi et al.
Bo Zhou et al.
DNA double-strand breaks (DSBs) are the most severe DNA damage, and defective repair can lead to apoptosis or malignant transformation. DSBs are mainly repaired by nonhomologous end joining (NHEJ) and homologous recombination (HR), while mi...
Stress-specific 14-3-3-client modules in digestive cancers: an evidence-graded review of adaptive survival and therapy resistance [0.03%]
消化系统癌症中的应激特异性14-3-3客户模块：适应性生存和治疗抵抗的分级证据回顾
Rudong Li,Zhipeng Zhao,Xudong Wang
Rudong Li
14-3-3 proteins are phosphoserine- and phosphothreonine-binding adaptors that regulate client localization, stability and activity under cellular stress. This narrative review synthesizes stress-specific 14-3-3-client modules in gastric, co...
Targeting molecular and genetic pathways driving tumorigenesis for precision therapy in colorectal cancer [0.03%]
针对结直肠癌精准治疗的肿瘤发生驱动途径分子和遗传通路研究
Allison S Doermann,Adi Caspi,Andrew E Evans et al.
Allison S Doermann et al.
Colorectal cancer (CRC) remains a major global health challenge and a leading cause of cancer-related mortality worldwide. Central to its pathogenesis is the dysregulation of interconnected signal transduction networks that govern cellular ...
Bis-(di-4-phenyl-benzylaminethiocarbonyl)disulfide sensitizes ABCC2/ALDH3A1 overexpressing NSCLC cells to cisplatin [0.03%]
二(ди-4-苯基-苯甲氨硫羰基)二硫化物使ABCC2/ALDH3A1高表达的非小细胞肺癌细胞对顺铂敏感
Jolanta Kryczka,Jakub Mateusz Kryczka,Łukasz Janczewski et al.
Jolanta Kryczka et al.
Background: Lung cancer presents complex etiopathology involving a mix of genetic predispositions and environmental factors. The best treatment modality is surgical resection. However, it becomes ineffective in the advanc...
xinguangA preliminary characterization of PI4K/PIPK alterations across solid tumors: an exploratory framework for prognostic and therapeutic stratification [0.03%]
PI4K/PIPK在实体肿瘤中的初步特征化：预后和治疗分层的探索框架
Yaqiong Jie,Zhongyu Lu,Xiaoxuan Wang et al.
Yaqiong Jie et al.
Background: This study aimed to systematically characterize the genomic alteration landscape of phosphatidylinositol 4-kinase (PI4K) and phosphatidylinositol phosphate kinase (PIPK) family genes in solid tumors, assess th...
Integrative single-cell and spatial transcriptomic approaches to decipher the tumor microenvironment and therapeutic resistance in pancreatic cancer [0.03%]
整合单细胞和空间转录组学方法解析胰腺癌肿瘤微环境及耐药机制
Mengting Luo,Feng Shen,Wanli Xu et al.
Mengting Luo et al.
Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive human malignancies and has an extremely poor prognosis. Its progression is largely driven by a highly complex and immunosuppressive tumor microenvironment (TME), highlight...
Effective treatment of human breast tumors by chimeric CCL2 and CCL8 diphtheria toxin cytotoxic peptides [0.03%]
嵌合型CCL2和CCL8白喉毒素细胞毒性多肽对人乳腺肿瘤的有效治疗作用
Bernardo Chavez,Vitali Sikirzhytski,Chang-Uk Lim et al.
Bernardo Chavez et al.
Objective: Chemokine receptors play crucial roles in tumor onset and progression, but the high redundancy between ligands and their receptors limits the possibilities to leverage them therapeutically for cancer management...
NSUN2 mediates SALL2 m5C methylation to inhibit ferroptosis and promote breast cancer progression [0.03%]
NSUN2介导SALL2 m5C甲基化抑制铁死亡促进乳腺癌进展
Jiawei Li,Min Li,Jianran Guo et al.
Jiawei Li et al.
Background: Due to the heterogeneity of breast cancer (BRCA) and the limited therapeutic efficacy in specific molecular subtypes, identifying new and effective therapeutic targets remains an urgent clinical need. The tran...
Targeting the PI3K/AKT pathway in prostate cancer: the role of PTEN deficiency and biomarker-guided therapy [0.03%]
靶向PI3K/AKT途径治疗前列腺癌：PTEN缺陷与生物标志物指导下的治疗作用
Allison Staton,Melissa Abel,William D Figg
Allison Staton
Loss of the PTEN tumor suppressor gene is a common molecular feature in advanced prostate cancer and is associated with activation of the PI3K/AKT signaling pathway, which controls cell growth and survival. Despite major advances in the tre...