Patient-derived organoids (PDOs) as a promising platform for personalized treatment of colorectal cancer: current applications and future challenges [0.03%]
基于患者的肿瘤类器官(PDOs)在结直肠癌的个性化治疗中的应用及未来挑战
Yan Liu,Yao Zhang,Ran Zhang et al.
Yan Liu et al.
Colorectal cancer is a heterogeneous and molecularly complex cancer that often leads to poor prognosis. The standard treatment includes surgical resection and adjuvant therapies such as chemotherapy, radiotherapy, targeted therapy, and immu...
Unveiling the oncogenic role of lncRNA PIG13-DT in hepatocellular carcinoma progression [0.03%]
长链非编码RNA PIG13-DT在肝癌进展中的致癌作用
Hongjie Cai,Song Chen,Shuangyan Tang et al.
Hongjie Cai et al.
Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality due to delayed diagnosis and poor prognosis. Long non-coding RNAs (lncRNAs) are key cancer regulators, yet the role of C1orf21-DT (...
Loss of ACSL1 fuels ferroptosis resistance in clear cell renal carcinoma [0.03%]
ACSL1丢失可驱动透明细胞肾癌的铁死亡抵抗作用
Shangguo Wang,Yuxiong Wang,Bin Liu et al.
Shangguo Wang et al.
Background: Clear cell renal cell carcinoma (ccRCC), the most common kidney cancer subtype, is marked by lipid metabolism reprogramming and therapy resistance. Ferroptosis-an iron-dependent, lipid peroxidation-driven cell...
Yes-associated protein 1 in cancer: bridging mechanical transduction and epigenetic regulation [0.03%]
Yes相关蛋白1与癌症：连接机械转导和表观遗传调控
Tingting Liu,Shuo Yu,Lu Zhang et al.
Tingting Liu et al.
Yes-associated protein 1 (YAP1) and its paralog TAZ serve as central mechanotransductive transcription coactivators that integrate mechanical cues from the extracellular matrix, such as stiffness and fluid shear stress, with epigenetic modi...
USP7 overexpression prevents the progression of clear cell renal cell carcinoma by enhancing pyroptosis via TRIP12 deubiquitination [0.03%]
USP7过表达通过TRIP12去泛素化促进细胞焦亡从而抑制透明细胞肾细胞癌进展
Hongsheng Li,Yao Ning,Junjie Yu et al.
Hongsheng Li et al.
Ubiquitin-specific protease 7 (USP7) involves in various human cancers due to its capacity for binding and stabilizing specific target proteins through deubiquitylation, but its roles in clear cell renal cell carcinoma (ccRCC) development r...
MiR-135a-3p inhibits the progression of prostate cancer by targeting TLR4 [0.03%]
miR-135a-3p通过靶向TLR4抑制前列腺癌进展
LianQiang Li,Xiao Zhang
LianQiang Li
To explore the expression of miR-135a-3p in prostate cancer，analyze its effects on tumor development and the involved mechanisms. A total of 125 specimens of cancer tissues and corresponding adjacent normal tissues from prostate cancer patie...
Adipose-Derived Exosomes: mediators of crosstalk between Adipose tissue and cancer [0.03%]
脂肪来源的外泌体：脂肪组织和癌症相互作用的介质
Changjian Wang,Zhikun Zheng,Chuangyan Wu et al.
Changjian Wang et al.
Adipose-derived exosomes (ADEs), a subtype of extracellular vesicles, are critical mediators of communication between adipose tissue and tumors, playing pivotal roles in cancer progression and therapeutic response. These nanoscale vesicles ...
Hypoxia-induced PYCR1 regulates glycolysis and histone lactylation to promote bladder cancer progression and metastasis via SLC6A14/Glutamine metabolism [0.03%]
缺氧诱导的PYCR1通过SLC6A14/谷氨酰胺代谢调节糖酵解和组蛋白乳酸化促进膀胱癌进展和转移
Zhuo Li,Qinghua Jiang,Quan Yang et al.
Zhuo Li et al.
Hypoxia-induced Pyrroline-5-Carboxylate Reductase 1 (PYCR1) is implicated in bladder cancer (BC), but its specific role remains elusive. This study investigated how PYCR1 promotes BC progression through glycolysis, histone H3 Lysine 18 Lact...
Establishing a pediatric solid tumor PDX biobank for precision oncology research [0.03%]
建立儿童实体肿瘤PDX生物样本库以促进精准肿瘤学研究
Larissa Akemi Kido,Milena Rodrigues Marusco,Ellen Aparecida da Silva et al.
Larissa Akemi Kido et al.
Developing advanced preclinical models and targeted therapies is essential for reducing cancer-related deaths in children with solid tumors. Patient-derived xenografts (PDX) have the potential to replicate key elements of the original tumor...
SLX1 silencing overcomes Olaparib resistance in metastatic castration-resistant prostate cancer by disrupting SLX4-mediated DNA repair complexes [0.03%]
沉默SLX1通过破坏SLX4介导的DNA修复复合物克服奥拉帕尼对转移性去势抵抗性前列腺癌的耐药性
Xin Zhao,Shiyun Feng,Xiaoping Nitie et al.
Xin Zhao et al.
Purpose: Metastatic castration-resistant prostate cancer (mCRPC) remains a significant therapeutic challenge and a leading cause of cancer-related mortality in men. PARP inhibitors like Olaparib are effective in homologou...