Sigma1 inhibitor suppression of adaptive immune resistance mechanisms mediated by cancer cell derived extracellular vesicles [0.03%]
σ1受体抑制剂阻断肿瘤细胞来源的外泌体介导的适应性免疫抵抗机制
Paola A Castagnino,Derick A Haas,Luca Musante et al.
Paola A Castagnino et al.
Adaptive immune resistance in cancer describes the various mechanisms by which tumors adapt to evade anti-tumor immune responses. IFN-γ induction of programmed death-ligand 1 (PD-L1) was the first defined and validated adaptive immune resi...
Targeting the IKZF1/BCL-2 axis as a novel therapeutic strategy for treating acute T-cell lymphoblastic leukemia [0.03%]
靶向IKZF1/BCL-2轴作为治疗急性T细胞淋巴母细胞白血病的新策略
Juan Li,Chunmei Ye,Hui Li et al.
Juan Li et al.
Objectives: Acute T-cell lymphoblastic leukemia (T-ALL) is a severe hematologic malignancy with limited treatment options and poor long-term survival. This study explores the role of IKZF1 in regulating BCL-2 expression i...
miR-301a-mediated crosstalk between the Hedgehog and HIPPO/YAP signaling pathways promotes pancreatic cancer [0.03%]
微RNA-301a介导的Hedgehog和HIPPO/YAP信号通路交叉对话促进胰腺癌发展
Bing Qi,Yuqiong Wang,Xian Zhu et al.
Bing Qi et al.
Pancreatic ductal adenocarcinoma (PDAC) poses a significant challenge in oncology due to its dismal prognosis and limited therapeutic options. In this study, we investigated the role of miR-301a in facilitating crosstalk between the Hedgeho...
Fractionated radiotherapy initiated at the early stage of bone metastasis is effective to prolong survival in mouse model [0.03%]
早期分次放疗有效延长小鼠骨转移生存时间
Yun Zhang,Zhunyi Gao,Ziwei Qi et al.
Yun Zhang et al.
Background and purpose: Bone metastasis is common for breast cancer and associated with poor prognosis. Currently, radiotherapy (RT) serves as the standard treatment for patients exhibiting symptoms of bone metastasis to ...
Effect of extracellular vesicle ZNF280B derived from lung cancer stem cells on lung cancer progression [0.03%]
肺癌干细胞衍生的细胞外囊泡ZNF280B对肺癌进展的影响
Qixia Guo,Jiayan Lu,Hui Zhao et al.
Qixia Guo et al.
Objective: The purpose of this research was to investigate the role of extracellular vesicles derived from lung cancer stem cells (lung CSCs-EVs) in lung cancer and to explore their potential mechanisms. ...
NVP-2, in combination with Orlistat, represents a promising therapeutic strategy for acute myeloid leukemia [0.03%]
NVP-2联合奥利司他代表了治疗急性髓系白血病的有希望的治疗策略
Qing Zhu,Jia Cheng,Yuqing Gao et al.
Qing Zhu et al.
Cell cycle dysregulation and the corresponding metabolic reprogramming play significant roles in tumor development and progression. CDK9, a kinase that regulates gene transcription and cell cycle, also induces oncogene transcription and abn...
RSK4 promotes the metastasis of clear cell renal cell carcinoma by activating RUNX1-mediated angiogenesis [0.03%]
RSK4通过激活RUNX1介导的血管生成促进透明细胞肾细胞癌的转移
Jing Ma,Yanru Yang,Kaijing Wang et al.
Jing Ma et al.
Ribosomal S6 protein kinase 4 (RSK4), a member of the serine‒threonine kinase family, plays a vital role in the Ras‒MAPK pathway. This kinase is responsible for managing several cellular activities, including cell growth, proliferation, s...
Long-term effects of neoadjuvant chemotherapy in variant histology locally advanced colon cancer: a propensity score-matched analysis [0.03%]
组织学分型局部晚期结肠癌新辅助化疗的长期影响：倾向性评分匹配分析
Qiancheng Wang,Shiyang Jin,Zeshen Wang et al.
Qiancheng Wang et al.
Purpose: Neoadjuvant chemotherapy (NAC) has proven valuable in treating locally advanced colon cancer (LACC) and is included as a treatment option for patients with clinical T4b colon cancer by the National Comprehensive ...
Knockdown of NDUFAF6 inhibits breast cancer progression via promoting mitophagy and apoptosis [0.03%]
NDUFAF6敲低通过促进线粒体自噬和细胞凋亡抑制乳腺癌进展
Shang Wu,Xindi Ma,Xiangmei Zhang et al.
Shang Wu et al.
Background: While NDUFAF6 is implicated in breast cancer, its specific role remains unclear. Methods: The expression levels and prognos...
Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis [0.03%]
darmisin通过靶向akt-hk2轴抑制肺癌糖酵解
Shi-Ming Tan,Lan Luo,Yi-Fu He et al.
Shi-Ming Tan et al.
Lung cancer, one of the most prevalent tumors, remains a clinical challenge with a poor five-year survival rate. Daurisoline, a bis-benzylisoquinoline alkaloid derived from the traditional Chinese herb Menispermum dauricum, is known to supp...