cGAS-STING signaling in the tumor microenvironment induces myeloid cell activation and favors T cell-mediated antitumor immunity [0.03%]
肿瘤微环境中cGAS-STING信号促进髓系细胞活化和T细胞抗肿瘤免疫
Meiqi Ren,Zhichao Eric Ai,Yan Zhang et al.
Meiqi Ren et al.
The cancer-immunity cycle is regulated by a series of stimulatory and inhibitory factors. The stimulator of interferon genes (STING) pathway, a key stimulator of type I interferon production, connects innate and adaptive immunity to promote...
NCAPD2 promotes the progression of lung adenocarcinoma through an AKT/MDM2/E2F1 positive feedback loop [0.03%]
NCAPD2通过AKT/MDM2/E2F1正反馈环促进肺腺癌进展
Yun Wu,Xiaoqin Li,Yuchen Lin et al.
Yun Wu et al.
Introduction: Lung adenocarcinoma (LUAD) is one of the leading causes of cancer-related deaths worldwide. While NCAPD2 has been implicated in promoting tumorigenesis across various cancer types, its specific role in LUAD ...
High-throughput screening identifies the activity of histone deacetylase inhibitors in patient-derived models of soft tissue sarcoma [0.03%]
高通量筛选确定组蛋白去乙酰化酶抑制剂在软组织肉瘤患者衍生模型中的活性
Molly R Danks,Piotr J Manasterski,Henry Beetham et al.
Molly R Danks et al.
Background: Undifferentiated pleomorphic sarcoma (UPS) is a rare and aggressive soft tissue sarcoma with limited treatment options and a poor prognosis. As a complex karyotype tumor, UPS lacks recurrent targetable mutatio...
CD44v5 enhances the IL-4/IL-4Rα/STAT6/SAM68 aix inducing M2 polarization and promoting triple-negative breast cancer progression [0.03%]
CD44v5通过增强IL-4/IL-4Rα/STAT6/SAM68轴诱导M2极化并促进三阴性乳腺癌进展
Zhongjian Ji,Lan Wang,Xinyi Bao et al.
Zhongjian Ji et al.
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype with a poor prognosis and limited treatment options. Tumor-associated macrophages (TAMs), the predominant and abundant immune cells in the tumor im...
ARNTL2 regulated the oncogene c-myc and promoted the progression of esophageal cancer through activating ANXA2 transcription [0.03%]
ARNTL2通过激活ANXA2转录促进食管癌进展及调控原癌基因c-myc的作用机制研究
Yanzi Qin,Hongfei Ci,Zhaoyi Wang et al.
Yanzi Qin et al.
Objective: Aryl hydrocarbon receptor nuclear transporter-like 2 (ARNTL2) can bind to clock circadian regulator (CLOCK) to regulate gene expression and is abnormally expressed in various cancers. Nevertheless, its effects ...
Potential therapeutic GSK-3β inhibitor 9-ING-41 is active in combination with venetoclax in double-hit lymphoma (DHL) [0.03%]
潜在的治疗性GSK-3β抑制剂9-ING-41与维奈克拉在双打击淋巴瘤(DHL)中的联合应用活性研究
Haohao Lei,Yunxia Zhang,Haiqing Zheng et al.
Haohao Lei et al.
Background: Double-hit lymphoma (DHL) exhibits aggressive behavior due to dysregulated proliferation and resistance to apoptosis. Current therapies, including R-CHOP, show limited efficacy, necessitating novel strategies....
Progress in the study of molecular markers in the prognosis assessment and recurrence patterns of glioblastoma [0.03%]
分子标记物在胶质母细胞瘤预后评估及复发模式中的研究进展
Yuqing Hu,Xiaoqin Ge,Qianyun Xie et al.
Yuqing Hu et al.
Glioblastoma multiforme (GBM), the most invasive primary malignant tumor of the central nervous system, is characterized by an extremely poor prognosis and a high recurrence rate. Its significant molecular heterogeneity challenges precise d...
The roles of the small nucleolar RNA host gene family in ovarian cancer [0.03%]
卵巢癌中snoRNA宿主基因家族的作用机制研究
Tao Zhang,Dapeng Wu,Zhongjie Li et al.
Tao Zhang et al.
Ovarian cancer is one of the most malignant tumors in women. Long noncoding RNAs have been demonstrated to regulate multiple biological processes, including cell proliferation, migration, apoptosis, and drug resistance, in various cancers. ...
Challenges and caveats in manipulating extracellular vesicle secretion from pancreatic cancer cells [0.03%]
操纵胰腺癌细胞释放外泌体的挑战和局限性
Jennifer M Finan,Jonathan R Brody
Jennifer M Finan
Background: Extracellular vesicle (EV) signaling is important in multiple malignancies, including pancreatic ductal adenocarcinoma (PDAC). In this coordinated cell‒cell signaling mechanism, genetically altered tumor cell...