Jujuboside A induces bladder cancer cell apoptosis by inhibiting ATP1A2-mediated mitochondrial energy metabolism regulation [0.03%]
金枣苷A通过抑制ATP1A2介导的线粒体能量代谢对膀胱癌细胞发挥诱导凋亡作用
Meng Zhu,Yuepeng Liu,Yumin Jia et al.
Meng Zhu et al.
Background: Conventional treatments for bladder cancer exhibit various limitations. Therefore, natural products, such as jujuboside A (JuA), have been explored for their multi-target effects and low toxicity. However, the...
Methodological insights regarding the prognostic value of lncRNA PGM5P4-AS1 in breast cancer [0.03%]
关于lncRNA PGM5P4-AS1在乳腺癌预后价值的方法学洞见
Rashad Ismayilov,Arzu Oguz
Rashad Ismayilov
Evaluating carboplatin and PARP inhibitor combination efficacy using high-grade serous carcinoma spheroids and organoids [0.03%]
采用高级别浆液性癌类器官和球状体评估卡铂与PARP抑制剂联合用药的疗效
Emily J Tomas,Jennifer Davis,Yudith Ramos Valdes et al.
Emily J Tomas et al.
Background: PARP inhibitors (PARPis) are new targeted agents that exploit homologous recombination DNA repair deficiencies (HRDs), which are present in 50% of high-grade serous carcinoma (HGSC) cases. Currently, olaparib ...
Lenvatinib potentiates the antitumor efficacy of combined radiotherapy and PD-L1 blockade in lung adenocarcinoma [0.03%]
仑伐替尼增敏放射治疗联合PD-L1阻断在肺腺癌中的抗肿瘤效应
Yudi Liu,Ling Xiao,Xinyu Nie et al.
Yudi Liu et al.
Background: The potential of Lenvatinib to synergize with combined radiotherapy and immunotherapy in LUAD remains incompletely characterized. Methods: ...
Downregulation of the lncRNA PGM5P4-AS1 predicts poor prognosis and drives breast cancer progression through miR-3664-5p/KLF9 [0.03%]
lncRNA PGM5P4-AS1低表达预测乳腺癌预后不良并通过miR-3664-5p/KLF9驱动乳腺癌进展
Yifan Wu,Jiangdong Jin,Yuhan Zhang et al.
Yifan Wu et al.
Background: Accumulating evidence suggests that deregulated long non-coding RNAs (lncRNAs) drive breast cancer (BRCA) progression. This study investigated the expression profile and mechanism of PGM5P4 antisense RNA 1 (PG...
Assessing progesterone receptor modulation in glioblastoma: from in vitro and animal model to a human pilot protocol [0.03%]
体外和动物模型在胶质母细胞瘤中评估孕激素受体调节作用并制定人类试验方案
Denisse Arcos-Montoya,Patricia García-López,Talia Wegman-Ostrosky et al.
Denisse Arcos-Montoya et al.
Background: Gliomas, including glioblastomas (GB) and high-grade astrocytomas (HGA), are the most common brain tumors in adults, with poor survival rates around 15 months. Hormonal factors, particularly progesterone recep...
Interaction between ZMIZ2 and AR promotes prostate cancer proliferation in vitro and in vivo [0.03%]
ZMIZ2与AR的相互作用通过体内和体外实验促进前列腺癌增殖
Jing-Ze Yu,Xiao-Pan Zou,Xiao-Bei Wu et al.
Jing-Ze Yu et al.
Background: ZMIZ2, an androgen receptor (AR) transcriptional co-regulator, promotes prostate cancer (PCa) cell proliferation by interacting with AR to upregulate genes associated with cell proliferation; however, its spec...
PI3Kγ inhibition drives M1 macrophage differentiation and synergizes with PD-L1 blockade to improve survival in poorly immunogenic head and neck squamous cell carcinoma [0.03%]
PI3Kγ抑制促进M1型巨噬细胞分化并能与PD-L1阻断协同作用以提高对免疫原性较低的头颈鳞状细胞癌小鼠模型的治疗效果以提高生存率
Pete P Jordanides,Sushmitha Jagadeesha,Puja Upadhaya et al.
Pete P Jordanides et al.
Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer globally with high mortality rates, highlighting the urgent need for novel therapeutic strategies. We investigated the efficacy of ...
Identification of coilin in bone marrow as a potential neuroblastoma tumor progression marker transcriptionally regulated by MYCN [0.03%]
鉴定骨髓中的coilin作为潜在的由MYCN转录调控的神经母细胞瘤肿瘤进展标志物
Zhixia Yue,Lan Li,Shuguang Liu et al.
Zhixia Yue et al.
Background: Current risk stratification for neuroblastoma (NB) relies on limited markers like MYCN amplification. Coilin, a key Cajal body component, regulates cellular processes. This study investigates whether coilin ex...