Advances in natural killer cell immunotherapy for hematologic malignancies [0.03%]
自然杀伤细胞免疫治疗血液系统恶性肿瘤的新进展
Huijie Hu,Yan Xiong,Minxin Xia et al.
Huijie Hu et al.
Natural killer (NK) cells are a unique subset of cytotoxic lymphocytes within the innate immune system. They play a pivotal role in antiviral and antitumor immunity. NK cell-based adoptive immunotherapy has advanced rapidly in recent years....
Real-world efficacy of Bruton tyrosine kinase inhibitor based maintenance therapy in diffuse large B-cell lymphoma: a multicenter retrospective cohort study with external historical control [0.03%]
布鲁顿酪氨酸激酶抑制剂维持治疗弥漫大B细胞淋巴瘤真实世界疗效的多中心回顾队列研究及历史对照研究
Li-Wei Lyu,Na Yao,Zi-Xian Liu et al.
Li-Wei Lyu et al.
Introduction: The selection of an optimal maintenance agent in diffuse large B-cell lymphoma (DLBCL) continues to pose a significant clinical challenge. This study aims to evaluate the prognostic impact of maintenance the...
Multicenter Study
Cancer biology & therapy. 2026 Dec 31;27(1):2662031. DOI:10.1080/15384047.2026.2662031 2026
Molecular mechanisms and therapeutic strategies: DNA methylation in pancreatic cancer [0.03%]
分子机制和治疗策略：胰腺癌中的DNA甲基化
Junlin Liu,Junhua Xie,Yunyu Ding
Junlin Liu
Objective: This narrative review examines DNA methylation dysregulation in pancreatic cancer, focusing on its mechanistic roles in tumorigenesis and applications in biomarkers and therapies. ...
Epigenetic silencing L3MBTL4 sensitizes esophageal cancer to DNA-PKcs inhibitor [0.03%]
表观遗传抑制L3MBTL4使食管癌对DNA-PKcs抑制剂敏感化
Yuan Li,Aiai Gao,Yuanxin Yao et al.
Yuan Li et al.
Background: Esophageal squamous cell carcinoma (ESCC) remains a deadly disease, with no effective therapeutics available for advanced stages. The application of the "synthetic lethality" principle to cancers with abnormal...
The MYBL2-GTSE1 axis promotes laryngeal squamous cell carcinoma progression by regulating PI3K/AKT-dependent glycolytic reprogramming [0.03%]
MYBL2-GTSE1轴通过调节PI3K/AKT依赖性糖酵解重组促进喉鳞状细胞癌进展
Yiyin Liang,Cansi Wang,Tianjiao Ren et al.
Yiyin Liang et al.
Background: Laryngeal squamous cell carcinoma (LSCC) is a common head and neck malignancy with poor prognosis. The role of MYBL2, an oncogenic transcription factor, in the glycolytic reprogramming of LSCC remains unclear....
Deguelin inhibits perineural invasion in esophageal squamous cell carcinoma via targeting BDNF/TrkB axis [0.03%]
deguelin通过靶向bdnf/trkb轴抑制食管鳞癌的癌周神经浸润
Qiying Wei,Liuyang Bai,Liangying Yan et al.
Qiying Wei et al.
Background: Perineural invasion (PNI) represents a uniquely distinctive pathway for tumor metastasis, but its underlying molecular mechanisms and therapy remain unclear. ...
The role of copper and cuproptosis in digestive system cancers: novel therapeutic strategies and mechanistic insights [0.03%]
铜和杯立托普西斯在消化系统癌症中的作用：新型治疗策略和机制洞察
Guoshuai Xu,Nan Yao,Renjia Cheng et al.
Guoshuai Xu et al.
Recent research has highlighted the critical role of copper metabolism and a novel form of copper-dependent cell death, termed cuproptosis, in the progression and treatment of these cancers. Copper, an essential trace element, plays a cruci...
Research progress on the compositional characteristics of the tumor immune microenvironment and immunopredictive models in esophageal squamous cell carcinoma [0.03%]
食管鳞癌肿瘤免疫微环境组成特征及免疫预测模型的研究进展
Gongcheng Wang,Zhenzhen Li,Siyu Tan et al.
Gongcheng Wang et al.
Esophageal cancer is one of the most prevalent malignant tumors of the digestive tract, with esophageal squamous cell carcinoma (ESCC) as its main histological type. In recent years, immunotherapeutic regimens centered on immune checkpoint ...
ENPP3 drives ccRCC progression by cGAMP hydrolysis and STING-IFN suppression [0.03%]
ENPP3通过cGAMP降解和STING-IFN抑制驱动ccRCC进展
Jiaxing Ma,Yayun Wu,Guangzheng Lin et al.
Jiaxing Ma et al.
Objective: Clear-cell renal cell carcinoma (ccRCC) is an immune-desert tumor. This study investigates the role of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a potential therapeutic target and immune-che...
Glutamine transporter SLC1A5 inhibits autophagy-mediated CD276 degradation to promote esophageal cancer progression [0.03%]
谷氨酰胺转运蛋白SLC1A5通过抑制自噬介导的CD276降解促进食管癌进展
Chunyan Wang,Hongyan Zhang,Chaonan Guan et al.
Chunyan Wang et al.
Background: CD276/B7-H3 is an immune checkpoint molecule often overexpressed in cancers, representing a potential therapeutic target. The underlying mechanisms for CD276 upregulation remain unclear. This study investigate...