Suppression of LncRNA AC008406.3 sensitizes breast cancer cells to docetaxel via triggering cuproptosis [0.03%]
LncRNA AC008406.3的抑制通过诱导铜死亡增强乳腺癌细胞对多西他赛的敏感性
Chenguang Liu,Shiyang Liu,Zonghong Lu et al.
Chenguang Liu et al.
Background: Docetaxel (DTX) is one of the commonly used chemotherapeutic agents for breast cancer. Cuproptosis, a newly defined form of cell death, significantly influences tumor progression. This study aims to identify c...
Diagnostic and prognostic value of lncSPATA8-AS1 in prostate cancer and its regulatory effect on tumor progression [0.03%]
长链非编码RNA lncSPATA8-AS1在前列腺癌中的诊断、预后价值及其对肿瘤进展的调控作用
Jinman Zhong,Yanmeng Deng,Xingru Qin et al.
Jinman Zhong et al.
Background: Long noncoding RNAs (lncRNAs) have significant impacts on the occurrence and development of many cancers. However, their effects and mechanisms on prostate cancer (PCa) remain largely unknown. The study was to...
Impact of leucine-rich diet on placenta's proteomic and metabolomic profiles of pregnant tumor-bearing rats [0.03%]
亮氨酸丰富饮食对携瘤妊娠大鼠胎盘蛋白质组和代谢组图谱的影响
Igor Fernando Dos Santos,Carla de Moraes Salgado,Victor Corasolla Carregari et al.
Igor Fernando Dos Santos et al.
Background: Cancer during pregnancy is a fragile scenario where the maternal body undergoes significant molecular changes, including at proteomic and metabolomic levels, with damage to placenta and fetal development. Prot...
Prolonged intratumoral treatment with TLR7/8 agonist R848 regulates the tumor immune microenvironment resulting in enhanced antitumor activity [0.03%]
TLR7/8激动剂R848的瘤内长效治疗通过重塑肿瘤免疫微环境增强抗肿瘤效应
Yue Zhang,Xueyi Sun,Shixuan Cheng et al.
Yue Zhang et al.
Background: Toll-like receptor 7/8 agonists (TLR7/8a), such as resiquimod (R848), are highly potent in activating dendritic cells and thus hold promise for T cell-mediated tumor immunotherapies. However, the short half-li...
Centromere protein I promotes hepatocellular carcinoma progression by activating PI3K/AKT/mTOR-CDK2 cascade [0.03%]
染色体客粒蛋白I通过激活PI3K/AKT/mTOR-CDK2信号通路促进肝癌进展
Demeng Liu,Peihao Yang,Jiyao Wang et al.
Demeng Liu et al.
Background: Hepatocellular carcinoma (HCC) is characterized by high recurrence rates and limited targeted therapies. Centromere protein I (CENPI), a core kinetochore component linked to chromosomal instability, is dysregu...
Inhibition of STAT3-mediated glycolysis by bruceine D suppresses non-small-cell lung cancer progression in vitro and in vivo [0.03%]
布鲁斯宁D通过抑制STAT3介导的糖酵解抑制体外和体内非小细胞肺癌进展
Yu Zhu,Xuan Xu,Xiaofan Hong et al.
Yu Zhu et al.
Background: Non-small-cell lung cancer (NSCLC) is one of the deadliest malignancies in the world. Signal transducer and activator of transcription 3 (STAT3) plays an important role in the progression of NSCLC. Bruceine D ...
MBD2 suppresses SFRP1 expression and promotes colorectal cancer development by blocking MED19 binding to its methylated promoter [0.03%]
MBD2通过阻止MED19与甲基化启动子结合来抑制SFRP1的表达并促进结直肠癌的发展
Xiuji Huang,Tingting Luo,Lingling Ke et al.
Xiuji Huang et al.
Background: The Wnt signaling pathway antagonist SFRP1 is frequently silenced by promoter DNA hypermethylation in colorectal cancer (CRC). MBD2, a DNA methylation reader, is known to contribute to SFRP1 epigenetic silenci...
IGF2BP3 promotes gastric cancer progression by inhibiting ferroptosis through ETV4-mediated regulation of GCH1 [0.03%]
IGF2BP3通过ETV4介导调节GCH1抑制铁死亡促进胃癌进展
Kan Li,Hui Wei,Fang Li et al.
Kan Li et al.
Background: Ferroptosis can be inhibited by insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) in cancers. ETS variant transcription factor 4 (ETV4) is aberrantly expressed in various cancers. Elevated transcri...
Parthenolide inhibits the progression of intrahepatic cholangiocarcinoma by promoting ferroptosis through inhibiting UBD [0.03%]
帕塞因通过抑制UBD促进肝内胆管癌铁死亡从而抑制其进展
Yuanzhu Xie,Jia Wang,Jia Zhou et al.
Yuanzhu Xie et al.
Objective: This study aimed to investigate the antitumor activity and molecular mechanism of Parthenolide (Par) against intrahepatic cholangiocarcinoma (ICC), a highly malignant liver tumor with poor prognosis, to explore...
UCHL5 suppresses thyroid carcinoma progression via ZRANB1 stabilization and ferroptosis regulation [0.03%]
UCHL5通过稳定ZRANB1和调节铁死亡来抑制甲状腺癌进展
Wenxia Xiao,Yu Ding,Xuesuo Wu et al.
Wenxia Xiao et al.
Objective: This study investigated the role of UCHL5 in thyroid carcinoma (THCA) progression, focusing on its tumor-suppressive mechanisms and regulation of ferroptosis. ...