Advancements in exosome-based cancer diagnosis: from chipsets to nano vaccine [0.03%]
基于外泌体的癌症诊断进展：从芯片到纳米疫苗
Nobendu Mukerjee,Subham Sarkar,Daniel Ejim Uti et al.
Nobendu Mukerjee et al.
Exosome-based therapies represent a pioneering frontier in cancer treatment, leveraging the natural cellular communication mechanisms encapsulated in exosomes. These nano-sized vesicles serve as carriers of proteins, lipids, and nucleic aci...
A comparison of cell death pathways in three different kinds of human lung cancer cell lines following hematoporphyrin derivative-mediated photodynamic therapy [0.03%]
血卟啉衍生物介导的光动力学治疗后三种不同人肺癌细胞株凋亡途径的研究比较分析
Yijiang Ma,Baohong Xiao,Aihua Sui et al.
Yijiang Ma et al.
This study was conducted to investigate the in vitro differences in killing effects and cellular death pathways in human bronchial epithelial BEAS-2B cells, human lung adenocarcinoma A549 cells, human lung squamous carcinoma H520 cells, and...
Cooperative CCL2/CCR2 and HGF/MET signaling enhances breast cancer growth and invasion associated with metabolic reprogramming [0.03%]
CCL2/CCR2和HGF/MET信号协作通过代谢重编程序增强乳腺癌的生长和侵袭性
Wei Fang,Yuuka Kozai,Diana S Acevedo et al.
Wei Fang et al.
With over 60,000 cases diagnosed in women annually, ductal carcinoma in situ (DCIS) is the most common form of pre-invasive breast cancer in the US. Despite standardized therapy, under-treatment and over-treatment are prevailing concerns. B...
Copper death combination therapy: the innovative frontier and challenges in prostate cancer treatment [0.03%]
铜死亡联合治疗：前列腺癌治疗的新前沿与挑战
Jia Wei He,Pei Zhen Li,Zi Xuan Huang
Jia Wei He
Prostate cancer (PCA) remains a significant health challenge, necessitating the exploration of novel therapeutic strategies to enhance patient outcomes. Recent research has identified cuproptosis, a copper-dependent programmed cell death me...
Lenvatinib promotes hepatocellular carcinoma pyroptosis by regulating GSDME palmitoylation [0.03%]
仑伐替尼通过调节GSDME棕榈酰化促进肝癌细胞焦亡
Yuan Yuan,Mu-Ru Wang,Yang Ding et al.
Yuan Yuan et al.
Lenvatinib, as a multi-kinase inhibitor, has been approved as a first-line drug for patients with advanced hepatocellular carcinoma (HCC). Gasdermin E (GSDME)-mediated pyroptosis, a form of programmed cell death, can be induced by chemother...
Robust prediction of glioma prognosis by hypoxia-induced ferroptosis genes: VEGFA-XBP1 co-expression for salvage therapy [0.03%]
缺氧诱导的铁死亡基因对胶质瘤预后的稳健预测：VEGFA-XBP1共表达挽救疗法
Zhou Liwei,Lu Hanwen,Zhao Wenpeng et al.
Zhou Liwei et al.
Hypoxia as a hallmark of solid malignancies compromises therapeutic efficacy and prognosis. This study deciphers the functional role of hypoxia-induced ferroptosis in glioma prognosis. Hypoxia-related transcripts and ferroptosis markers wer...
USP44 promotes chemotherapeutic drug resistance of triple negative breast cancer through EZH2 protein stability [0.03%]
USP44通过EZH2蛋白稳定性促进三阴性乳腺癌的化疗耐药性
Pu Wu,Wanting Xiao,Junjie Ni et al.
Pu Wu et al.
Triple negative breast cancer (TNBC), a highly invasive breast cancer, is one of the leading causes of cancer-related mortality worldwide. Although chemotherapy remains the standard of care for TNBC, the development of chemotherapy resistan...
IFN-γ downregulates miR-4319 to enhance NLRC5 and MHC-I expression in MHC-I-deficient breast cancer cells [0.03%]
干扰素γ通过下调miR-4319促进NLRC5表达及MHCI分子的修复以增强 MHCI缺陷型乳腺癌细胞免疫原性
Ming-Zhen Zhao,Hua-Chuan Zheng,Yu Sun et al.
Ming-Zhen Zhao et al.
Sufficient MHC-I expression on cancer cells is essential for the recognition and killing of cancer cells by immune effector cytotoxic T-lymphocyte (CTL). An important mechanism of cancer immune escape is loss or down-regulation of MHC-I. Th...
Highly enriched exosomal lncRNA OIP5-AS1 regulates gastrointestinal stromal tumor (GIST) resistance to sunitinib through miR-145 and SOX9 [0.03%]
高丰度的肿瘤来源外泌体lncRNA OIP5-AS1通过miR-145/SOX9信号通路调控胃肠道间质瘤苏尼替尼耐药性
Cui-Hua Wang,Xin-Ming Yao,Chun-Xia Pan et al.
Cui-Hua Wang et al.
Targeted therapy-induced resistance is a significant factor contributing to treatment failure in patients with gastrointestinal stromal tumors (GIST). Despite the identification of the long non-coding RNA (lncRNA) OIP5-AS1 as a critical pla...
β-hydroxybutyrate, a ketone body, suppresses tumor growth, stemness, and invasive phenotypes in non-small cell lung cancer [0.03%]
β-羟丁酸通过抑制非小细胞肺癌的肿瘤生长、干性及侵袭表型来发挥抑癌作用
Yunlong Huang,Jiaxuan Ding,Yufeng Zhu et al.
Yunlong Huang et al.
Lung cancer is the most common cancer worldwide. The stemness and metastasis of tumor cells present major challenges to effective lung cancer treatment. Beta-hydroxybutyrate (BHB), a ketone body, plays a key role in various cancers. However...