ADAR1-circRAB5A-BIP axis governs radiotherapy resistance in colorectal cancer through coordinating protective autophagy and apoptosis [0.03%]
ADAR1-circRAB5A-BIP轴通过协调保护性自噬和凋亡治理结直肠癌放疗抗性
Wangsheng Chen,Xu Zhang,Zhengfei Zhao et al.
Wangsheng Chen et al.
Background: Colorectal cancer (CRC) ranks among the most prevalent malignancies globally, and radiotherapy remains a critical treatment modality. However, its efficacy is frequently compromised by acquired radioresistance...
Opsonization and timing as key determinants of MBTA immunotherapy efficacy in pancreatic adenocarcinoma and recurrence treatment [0.03%]
调理作用和时机是胰腺癌免疫疗法MBTA疗效的关键决定因素
Andrea Frejlachova,Radka Lencova,Ondrej Uher et al.
Andrea Frejlachova et al.
Background: Pancreatic adenocarcinoma is a highly aggressive cancer with very limited treatment options. This study aimed to optimize the efficacy of a previously developed tumor immunotherapy for the treatment of this di...
ULK1's role in cancer progression and its emerging therapeutic potential [0.03%]
UNC-51样激酶1在癌症进展中的作用及其新兴治疗潜力
Jack D Webb,Trevor G Shepherd
Jack D Webb
Macroautophagy (autophagy) enables cellular stress adaptation by degrading damaged components; ULK1, a serine/threonine kinase, initiates this process in response to nutrient and energy cues. While autophagy is well studied, few investigati...
Retinol dehydrogenase 11 promotes prostate cancer progression through upregulation of tropomyosin receptor kinase A [0.03%]
视黄醇脱氢酶11通过上调酪氨酸激酶受体A促进前列腺癌进展
Shenghan Wang,Shuyu Zhang,Zekun Xin et al.
Shenghan Wang et al.
Objective: To clarify the clinical significance and biological function of retinol dehydrogenase-11 (RDH11) in prostate cancer (PCa) and to elucidate the downstream signaling mechanism through which it drives tumor progre...
STARD10 promotes progression of HER2+ breast cancer and intracellular lipid metabolism via the cAMP/PKA/CREB1 signaling axis [0.03%]
STARD10通过cAMP/PKA/CREB1信号轴促进HER2阳性乳腺癌进展和细胞内脂质代谢
Siyao Liu,Jing Gao,Yichen Niu et al.
Siyao Liu et al.
Background: Although targeted therapies have improved clinical outcomes, HER2+ breast cancer remains a significant clinical challenge due to its aggressive behavior and unfavorable prognosis. Emerging evidence indicates t...
The tumor microenvironment in triple negative breast cancer and a strategy to improve responses to immunotherapy using cryoablation and immunostimulants [0.03%]
三阴性乳腺癌的肿瘤微环境及利用冷冻消融和免疫刺激剂改善对免疫治疗反应的策略
Ritvik Illindala,Yunpeng Yang,Tyler Mandt et al.
Ritvik Illindala et al.
One in eight women will develop breast cancer (BC) over their lifetime. Triple-negative breast cancer (TNBC) accounts for up to 20% of BC cases and has fewer treatment options, greater metastatic potential, a higher risk of recurrence, and ...
Neoplastic CD3⁺ B cells remodel the DLBCL tumor microenvironment via single-cell and spatial transcriptomics [0.03%]
单细胞和空间转录组学揭示新生成CD3+ B细胞重塑DLBCL肿瘤微环境
Mingxiao Lang,Youqin Feng,Li Zhou et al.
Mingxiao Lang et al.
Introduction: This study constructs a high-resolution multi-omics map of Diffuse Large B-Cell Lymphoma (DLBCL) by integrating single-cell, single-nucleus, and spatial transcriptomics. ...
Leveraging the bacteria for enhanced cancer immunotherapy: from a perspective of synthetic biology [0.03%]
合成生物学视角下利用细菌增强癌症免疫治疗
Xing Liu,Hejin Zhang,Renchun Du et al.
Xing Liu et al.
In recent years, synthetic biology has been widely applied to engineer and program cellular behaviors. Using this approach, bacteria can be designed to express immunotherapeutic agents, improve tumor targeting, and deliver therapeutic paylo...
RET fusion partners dictate oncogenic potential in undifferentiated spindle cell sarcomas [0.03%]
RET融合伙伴决定未分化梭形细胞肉瘤的致癌潜力
Qi Gui,Ying Zhang,Mei Yang et al.
Qi Gui et al.
Background: Spindle cell tumors with RET rearrangements exhibit variable clinical behaviors, ranging from benign to highly aggressive malignancies. The underlying heterogeneity is suspected to be associated with distinct ...
TFPI2 in tumor metastasis: a double-edged sword with clinical implications [0.03%]
肿瘤转移中的TFPI2：具有临床意义的双刃剑
Zhanli Guo,Yuanke Luo,Jinyu Wen et al.
Zhanli Guo et al.
Tissue factor pathway inhibitor 2 (TFPI2), a serine protease inhibitor, plays a multifaceted role in tumor metastasis. Traditionally viewed as a metastasis suppressor, it inhibits extracellular matrix (ECM) remodeling, epithelial-mesenchyma...