USP7 overexpression prevents the progression of clear cell renal cell carcinoma by enhancing pyroptosis via TRIP12 deubiquitination [0.03%]
USP7过表达通过TRIP12去泛素化促进细胞焦亡从而抑制透明细胞肾细胞癌进展
Hongsheng Li,Yao Ning,Junjie Yu et al.
Hongsheng Li et al.
Ubiquitin-specific protease 7 (USP7) involves in various human cancers due to its capacity for binding and stabilizing specific target proteins through deubiquitylation, but its roles in clear cell renal cell carcinoma (ccRCC) development r...
MiR-135a-3p inhibits the progression of prostate cancer by targeting TLR4 [0.03%]
miR-135a-3p通过靶向TLR4抑制前列腺癌进展
LianQiang Li,Xiao Zhang
LianQiang Li
To explore the expression of miR-135a-3p in prostate cancer，analyze its effects on tumor development and the involved mechanisms. A total of 125 specimens of cancer tissues and corresponding adjacent normal tissues from prostate cancer patie...
Adipose-Derived Exosomes: mediators of crosstalk between Adipose tissue and cancer [0.03%]
脂肪来源的外泌体：脂肪组织和癌症相互作用的介质
Changjian Wang,Zhikun Zheng,Chuangyan Wu et al.
Changjian Wang et al.
Adipose-derived exosomes (ADEs), a subtype of extracellular vesicles, are critical mediators of communication between adipose tissue and tumors, playing pivotal roles in cancer progression and therapeutic response. These nanoscale vesicles ...
Hypoxia-induced PYCR1 regulates glycolysis and histone lactylation to promote bladder cancer progression and metastasis via SLC6A14/Glutamine metabolism [0.03%]
缺氧诱导的PYCR1通过SLC6A14/谷氨酰胺代谢调节糖酵解和组蛋白乳酸化促进膀胱癌进展和转移
Zhuo Li,Qinghua Jiang,Quan Yang et al.
Zhuo Li et al.
Hypoxia-induced Pyrroline-5-Carboxylate Reductase 1 (PYCR1) is implicated in bladder cancer (BC), but its specific role remains elusive. This study investigated how PYCR1 promotes BC progression through glycolysis, histone H3 Lysine 18 Lact...
Establishing a pediatric solid tumor PDX biobank for precision oncology research [0.03%]
建立儿童实体肿瘤PDX生物样本库以促进精准肿瘤学研究
Larissa Akemi Kido,Milena Rodrigues Marusco,Ellen Aparecida da Silva et al.
Larissa Akemi Kido et al.
Developing advanced preclinical models and targeted therapies is essential for reducing cancer-related deaths in children with solid tumors. Patient-derived xenografts (PDX) have the potential to replicate key elements of the original tumor...
SLX1 silencing overcomes Olaparib resistance in metastatic castration-resistant prostate cancer by disrupting SLX4-mediated DNA repair complexes [0.03%]
沉默SLX1通过破坏SLX4介导的DNA修复复合物克服奥拉帕尼对转移性去势抵抗性前列腺癌的耐药性
Xin Zhao,Shiyun Feng,Xiaoping Nitie et al.
Xin Zhao et al.
Purpose: Metastatic castration-resistant prostate cancer (mCRPC) remains a significant therapeutic challenge and a leading cause of cancer-related mortality in men. PARP inhibitors like Olaparib are effective in homologou...
Functional validation of somatic variability in TP53 and KRAS for prediction of platinum sensitivity and prognosis in epithelial ovarian carcinoma patients [0.03%]
用于预测上皮性卵巢癌患者铂敏感性和预后的TP53和KRAS体细胞变异的功能验证
Al Obeed Allah Mohammad,Ali Esraa,Krus Ivona et al.
Al Obeed Allah Mohammad et al.
Concerning the dismal prognosis of chemoresistant patients with epithelial ovarian carcinoma (EOC), we aimed to follow up the findings of a previous whole-exome sequencing study using an orthogonal Sanger sequencing on the same patients and...
Unraveling the dual role of METTL3-mediated m6A RNA modification in bladder cancer: mechanisms, therapeutic vulnerabilities, and clinical implications [0.03%]
膀胱癌中METTL3介导的m6A修饰的双刃剑作用：机制、治疗靶点及临床意义
Hua Chun,Kangzhuo Baima
Hua Chun
Bladder cancer (BC) remains challenging due to its recurrence and metastasis, with METTL3-mediated m6 A RNA modification emerging as a key oncogenic driver. This review synthesizes METTL3's roles in BC progression, including tumor initiatio...
NR4A3 regulates anoikis resistance and metastasis of bladder cancer through EWSR1 [0.03%]
NR4A3通过EWSR1调节膀胱癌的悬浮耐受性和转移性
Li Fan,Yulin Zhou,Shouyong Liu et al.
Li Fan et al.
Bladder cancer (BLCA) is a common urinary malignancy with high metastatic potential. However, the mechanisms underlying its progression remain unclear. This study aimed to investigate the role and regulatory mechanisms of NR4A3, a nuclear r...
Dual role of CXCL10 in cancer progression: implications for immunotherapy and targeted treatment [0.03%]
CXCL10在癌症进展中的双重作用：对免疫治疗和靶向治疗的意义
Osama A Madkhali,Sivakumar S Moni,Yosif Almoshari et al.
Osama A Madkhali et al.
CXCL10 is a chemokine crucial for immune cell recruitment and inflammation modulation, especially within the tumor microenvironment. This review critically analyzes the underexplored role of CXCL10 in modulating JAK/STAT, MAPK/ERK, an...