Ameliorative effects of pyrazinoic acid against oxidative and metabolic stress manifested in rats with dimethylhydrazine induced colonic carcinoma [0.03%]
异丙炔酸改善dimethylhydrazine诱导的结肠癌小鼠的氧化及代谢压力的影响研究
Anil K Sahdev,Vinit Raj,Ashok K Singh et al.
Anil K Sahdev et al.
Pyrazinoic acid (PA) is structurally similar to nicotinic acid which acts on G-protein-coupled receptor (GPR109A). GPR109A expresses in colonic and intestinal epithelial sites, and involves in DNA methylation and cellular apoptosis. Therefo...
Effect of NK cell immunotherapy on immune function in patients with hepatic carcinoma: A preliminary clinical study [0.03%]
NK细胞免疫治疗对肝癌患者免疫功能影响的初步临床研究
Zilin Qin,Jibing Chen,Jianying Zeng et al.
Zilin Qin et al.
We investigated the effectiveness of adoptive transfer of KIR ligand-mismatched highly activated nature killer (HANK) cells in patients with hepatic carcinoma. Peripheral blood mononuclear cells were obtained and cultured in vitro to induce...
Decreased expression of ALDH5A1 predicts prognosis in patients with ovarian cancer [0.03%]
ALDH5A1表达沉默与卵巢癌患者预后密切相关
Xun Tian,Yingyan Han,Lan Yu et al.
Xun Tian et al.
Aldehyde dehydrogenase 5 family, member A1 (ALDH5A1) belongs to the superfamily of aldehyde dehydrogenases (ALDHs). However, the prognostic value of ALDH5A1 in ovarian cancer remains unclear. The aim of this study was to explore the relatio...
Comparative Study
Cancer biology & therapy. 2017 Apr 3;18(4):245-251. DOI:10.1080/15384047.2017.1295175 2017
The screening of a microRNA expression during development of human macrophages and mouse dendritic cells [0.03%]
人单核细胞和小鼠树突状细胞发育过程中筛选一微型rna表达式型
Eui Young So,Trisha Winchester,Toru Ouchi
Eui Young So
There is increasing evidence showing specific roles of microRNA in cell differentiation and cancer progression. Here we examine miRNA profiles during maturation of monocytes and bone marrow-derived dendritic cells (BMDCs) in human and mouse...
BRD4 inhibitor IBET upregulates p27kip/cip protein stability in neuroendocrine tumor cells [0.03%]
溴结构域蛋白4抑制剂IBET通过上调神经内分泌肿瘤细胞中p27kip/cip蛋白稳定性发挥作用
Lei Wang,Smita Matkar,Gengchen Xie et al.
Lei Wang et al.
The prevalence of neuroendocrine tumors (NETs) has recently been increasing. Although various drugs such as Octreotide and its analogs show certain efficacy, NETs in many patients progress and metastasize. It is desirable to develop new int...
Caspase 8 polymorphisms contribute to the prognosis of advanced lung adenocarcinoma patients after platinum-based chemotherapy [0.03%]
caspase 8多态性对晚期肺腺癌患者铂类化疗预后的影响分析
Di Liu,Wen Xu,Xi Ding et al.
Di Liu et al.
Lung cancer is the leading cause of cancer deaths in China, and about 60% of the cases are diagnosed with histological adenocarcinoma. The caspase 8 (CASP8) gene is a critical initiator of the extrinsic apoptosis pathway. To explore the rel...
Correlative analysis of plasma SN-38 levels and DPD activity with outcomes of FOLFIRI regimen for metastatic colorectal cancer with UGT1A1 *28 and *6 wild type and its implication for individualized chemotherapy [0.03%]
UGT1A1*28和*6野生型转移性结直肠癌患者FOLIFRI方案血浆SN-38浓度与DPD活性相关性分析及其对个体化化疗的启示
Xun Cai,Chuan Tian,Liwei Wang et al.
Xun Cai et al.
It remains uncertain whether there is an correlation between clinical pharmacokinetic parameters and outcomes for metastatic colorectal cancer especially with UGT1A1 *28 and *6 wild type (*1/*1-*1/*1) for serious events associated with Irin...
Hypoxia promotes chemotherapy resistance by down-regulating SKA1 gene expression in human osteosarcoma [0.03%]
缺氧通过下调SKA1基因表达促进人成骨肉瘤细胞化疗耐药性
Qiong Ma,Yinglong Zhang,Tao Liu et al.
Qiong Ma et al.
Drug resistance has always been the main problem in osteosarcoma treatment, and hypoxia seems to be one of the many causes for drug resistance. Therefore, in this study, we investigated how hypoxia triggers chemotherapy resistance in osteos...
Yurong Zheng,Wenju Mo,Yang Yu et al.
Yurong Zheng et al.
We report a 28-year-old woman who presented with a 6-year history of milk-like discharge from both of her nipples and was diagnosed with prolactinoma based on computed tomography (CT) findings and serum prolactin level. Further breast exami...
Presence of novel compound BCR-ABL mutations in late chronic and advanced phase imatinib sensitive CML patients indicates their possible role in CML progression [0.03%]
新型BCR-ABL突变体存在于慢性期和加速期的伊马替尼敏感的CML患者中，提示其可能在CML进展中的作用
Afia Muhammad Akram,Zafar Iqbal,Tanveer Akhtar et al.
Afia Muhammad Akram et al.
BCR-ABL kinase domain (KD) mutations are well known for causing resistance against tyrosine kinase inhibitors (TKIs) and disease progression in chronic myeloid leukemia (CML). In recent years, compound BCR-ABL mutations have emerged as a ne...