Integrative single-cell and spatial transcriptomic approaches to decipher the tumor microenvironment and therapeutic resistance in pancreatic cancer [0.03%]
整合单细胞和空间转录组学方法解析胰腺癌肿瘤微环境及耐药机制
Mengting Luo,Feng Shen,Wanli Xu et al.
Mengting Luo et al.
Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive human malignancies and has an extremely poor prognosis. Its progression is largely driven by a highly complex and immunosuppressive tumor microenvironment (TME), highlight...
Effective treatment of human breast tumors by chimeric CCL2 and CCL8 diphtheria toxin cytotoxic peptides [0.03%]
嵌合型CCL2和CCL8白喉毒素细胞毒性多肽对人乳腺肿瘤的有效治疗作用
Bernardo Chavez,Vitali Sikirzhytski,Chang-Uk Lim et al.
Bernardo Chavez et al.
Objective: Chemokine receptors play crucial roles in tumor onset and progression, but the high redundancy between ligands and their receptors limits the possibilities to leverage them therapeutically for cancer management...
NSUN2 mediates SALL2 m5C methylation to inhibit ferroptosis and promote breast cancer progression [0.03%]
NSUN2介导SALL2 m5C甲基化抑制铁死亡促进乳腺癌进展
Jiawei Li,Min Li,Jianran Guo et al.
Jiawei Li et al.
Background: Due to the heterogeneity of breast cancer (BRCA) and the limited therapeutic efficacy in specific molecular subtypes, identifying new and effective therapeutic targets remains an urgent clinical need. The tran...
Targeting the PI3K/AKT pathway in prostate cancer: the role of PTEN deficiency and biomarker-guided therapy [0.03%]
靶向PI3K/AKT途径治疗前列腺癌：PTEN缺陷与生物标志物指导下的治疗作用
Allison Staton,Melissa Abel,William D Figg
Allison Staton
Loss of the PTEN tumor suppressor gene is a common molecular feature in advanced prostate cancer and is associated with activation of the PI3K/AKT signaling pathway, which controls cell growth and survival. Despite major advances in the tre...
ABHD17C regulates the efficacy of lenvatinib in suppressing hepatocellular carcinoma [0.03%]
ABHD17C调节Lenvatinib抑制肝癌功效的作用机制研究
Linpei Wang,Jiawei Wang,Xiaoqiu Ma et al.
Linpei Wang et al.
Introduction: Lenvatinib is a first-line therapy for hepatocellular carcinoma (HCC), but its clinical efficacy is limited by drug resistance. ABHD17C, a depalmitoylation enzyme involved in HCC progression, has not been in...
Advances in SEC61G research: from ER translocon subunit to emerging pan-cancer oncogenic roles [0.03%]
SEC61G研究进展：从内质网转位子亚基到新兴的泛癌症致癌作用角色
Yu-Nan Man,Mao-Lin He
Yu-Nan Man
SEC61G, the γ subunit of the Sec61 translocon, has long been regarded as a passenger co-amplification target of EGFR on chromosome 7p11.2. Recent studies have revealed its independent oncogenic functions across multiple cancers. This revie...
Efficacy and safety profiles of CDK4/6 inhibitor in patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer (ABC) from the high-altitude versus low-altitude regions: a multi-center retrospective study [0.03%]
高海拔地区与低海拔地区激素受体阳性的人表皮生长因子受体2阴性晚期乳腺癌患者使用CDK4/6抑制剂的有效性和安全性特征：一项多中心回顾性研究
Yujing Tan,Yinyin Ye,Weihong Zhao et al.
Yujing Tan et al.
Background: CDK4/6 inhibitors (CDK4/6i) represent the standard treatment for HR+/HER2- ABC. The study assessed the efficacy and safety profiles of CDK4/6i from first-line (1 L) to third-line (3 L) in patients with HR+/HER...
Multicenter Study
Cancer biology & therapy. 2026 Dec 31;27(1):2683159. DOI:10.1080/15384047.2026.2683159 2026
The dual role of leukotrienes in the tumor microenvironment: balancing pro-tumorigenic and anti-tumor immunity [0.03%]
白三烯在肿瘤微环境中的双重作用：促肿瘤和抗肿瘤免疫间的平衡
Andrew Thake,Maria Caruso,Sebastian Fernandez-Bussy et al.
Andrew Thake et al.
Background: Leukotrienes are bioactive lipid mediators produced via the 5-lipoxygenase (5-LO) pathway and are essential for inflammatory signaling in the tumor microenvironment (TME), playing roles in angiogenesis, immune...
CD69 blockade restores the bone marrow niche and delays leukemogenesis in a mouse model of Nras G12D-driven chronic myelomonocytic leukemia [0.03%]
CD69阻断可恢复骨髓生态位，并可在NrasG12D驱动的慢性粒单核细胞白血病小鼠模型中延缓白血病发生
Yuchen Li,Xu Jiang,Yinfeng Gu et al.
Yuchen Li et al.
Background: A subset of patients with chronic myelomonocytic leukemia (CMML) carries NRAS mutations, which are associated with shorter overall survival and an increased risk of transformation to acute myeloid leukemia. Ho...
KIF18A inhibitor prevents chromosomally unstable osteosarcoma growth by activating spindle assembly checkpoint [0.03%]
KIF18A抑制剂通过激活纺锤体组装检验点防止染色体不稳定型骨肉瘤生长
Qiang Yan,Yan Zhang,Pengfei Wang et al.
Qiang Yan et al.
Background: Osteosarcoma survival rates have not improved significantly in decades, as complex gene mutations and intratumoral heterogeneity hinder new therapy development. To exploit the widespread chromosomal instabilit...