ARNTL2 regulated the oncogene c-myc and promoted the progression of esophageal cancer through activating ANXA2 transcription [0.03%]
ARNTL2通过激活ANXA2转录促进食管癌进展及调控原癌基因c-myc的作用机制研究
Yanzi Qin,Hongfei Ci,Zhaoyi Wang et al.
Yanzi Qin et al.
Objective: Aryl hydrocarbon receptor nuclear transporter-like 2 (ARNTL2) can bind to clock circadian regulator (CLOCK) to regulate gene expression and is abnormally expressed in various cancers. Nevertheless, its effects ...
Potential therapeutic GSK-3β inhibitor 9-ING-41 is active in combination with venetoclax in double-hit lymphoma (DHL) [0.03%]
潜在的治疗性GSK-3β抑制剂9-ING-41与维奈克拉在双打击淋巴瘤(DHL)中的联合应用活性研究
Haohao Lei,Yunxia Zhang,Haiqing Zheng et al.
Haohao Lei et al.
Background: Double-hit lymphoma (DHL) exhibits aggressive behavior due to dysregulated proliferation and resistance to apoptosis. Current therapies, including R-CHOP, show limited efficacy, necessitating novel strategies....
Progress in the study of molecular markers in the prognosis assessment and recurrence patterns of glioblastoma [0.03%]
分子标记物在胶质母细胞瘤预后评估及复发模式中的研究进展
Yuqing Hu,Xiaoqin Ge,Qianyun Xie et al.
Yuqing Hu et al.
Glioblastoma multiforme (GBM), the most invasive primary malignant tumor of the central nervous system, is characterized by an extremely poor prognosis and a high recurrence rate. Its significant molecular heterogeneity challenges precise d...
The roles of the small nucleolar RNA host gene family in ovarian cancer [0.03%]
卵巢癌中snoRNA宿主基因家族的作用机制研究
Tao Zhang,Dapeng Wu,Zhongjie Li et al.
Tao Zhang et al.
Ovarian cancer is one of the most malignant tumors in women. Long noncoding RNAs have been demonstrated to regulate multiple biological processes, including cell proliferation, migration, apoptosis, and drug resistance, in various cancers. ...
Challenges and caveats in manipulating extracellular vesicle secretion from pancreatic cancer cells [0.03%]
操纵胰腺癌细胞释放外泌体的挑战和局限性
Jennifer M Finan,Jonathan R Brody
Jennifer M Finan
Background: Extracellular vesicle (EV) signaling is important in multiple malignancies, including pancreatic ductal adenocarcinoma (PDAC). In this coordinated cell‒cell signaling mechanism, genetically altered tumor cell...
Patient-derived organoids (PDOs) as a promising platform for personalized treatment of colorectal cancer: current applications and future challenges [0.03%]
基于患者的肿瘤类器官(PDOs)在结直肠癌的个性化治疗中的应用及未来挑战
Yan Liu,Yao Zhang,Ran Zhang et al.
Yan Liu et al.
Colorectal cancer is a heterogeneous and molecularly complex cancer that often leads to poor prognosis. The standard treatment includes surgical resection and adjuvant therapies such as chemotherapy, radiotherapy, targeted therapy, and immu...
Unveiling the oncogenic role of lncRNA PIG13-DT in hepatocellular carcinoma progression [0.03%]
长链非编码RNA PIG13-DT在肝癌进展中的致癌作用
Hongjie Cai,Song Chen,Shuangyan Tang et al.
Hongjie Cai et al.
Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality due to delayed diagnosis and poor prognosis. Long non-coding RNAs (lncRNAs) are key cancer regulators, yet the role of C1orf21-DT (...
Loss of ACSL1 fuels ferroptosis resistance in clear cell renal carcinoma [0.03%]
ACSL1丢失可驱动透明细胞肾癌的铁死亡抵抗作用
Shangguo Wang,Yuxiong Wang,Bin Liu et al.
Shangguo Wang et al.
Background: Clear cell renal cell carcinoma (ccRCC), the most common kidney cancer subtype, is marked by lipid metabolism reprogramming and therapy resistance. Ferroptosis-an iron-dependent, lipid peroxidation-driven cell...
Yes-associated protein 1 in cancer: bridging mechanical transduction and epigenetic regulation [0.03%]
Yes相关蛋白1与癌症：连接机械转导和表观遗传调控
Tingting Liu,Shuo Yu,Lu Zhang et al.
Tingting Liu et al.
Yes-associated protein 1 (YAP1) and its paralog TAZ serve as central mechanotransductive transcription coactivators that integrate mechanical cues from the extracellular matrix, such as stiffness and fluid shear stress, with epigenetic modi...