Rethinking Causation in Cancer with Evolutionary Developmental Biology [0.03%]
从进化发育生物学视角再思考癌症的病因学问题
Katherine E Liu
Katherine E Liu
Despite the productivity of basic cancer research, cancer continues to be a health burden to society because this research has not yielded corresponding clinical applications. Many proposed solutions to this dilemma have revolved around imp...
A Phenomenological and Dynamic View of Homology: Homologs as Persistently Reproducible Modules [0.03%]
同源性的现象学和动态观点：同源物作为持久可再现的模块
Daichi G Suzuki,Senji Tanaka
Daichi G Suzuki
Homology is a fundamental concept in biology. However, the metaphysical status of homology, especially whether a homolog is a part of an individual or a member of a natural kind, is still a matter of intense debate. The proponents of the in...
J H van Hateren
J H van Hateren
A new theory that naturalizes biological function is explained and compared with earlier etiological and causal role theories. Etiological (or selected effects) theories explain functions from how they are caused over their evolutionary his...
Harry Smit
Harry Smit
Darwin's theory predicts that linguistic behavior gradually evolved out of animal forms of communication (signaling). However, this prediction is confronted by the conceptual problem that there is an essential difference between signaling a...
Epidemiology Without Biology: False Paradigms, Unfounded Assumptions, and Specious Statistics in Radiation Science (with Commentaries by Inge Schmitz-Feuerhake and Christopher Busby and a Reply by the Authors) [0.03%]
缺乏生物学的流行病学：辐射科学中的错误范式、无根据假设和可疑统计（作者回应以及Inge Schmitz-Feuerhake与Christopher Busby评论）
Bill Sacks,Gregory Meyerson,Jeffry A Siegel
Bill Sacks
Radiation science is dominated by a paradigm based on an assumption without empirical foundation. Known as the linear no-threshold (LNT) hypothesis, it holds that all ionizing radiation is harmful no matter how low the dose or dose rate. Ep...
Jorge Wagensberg
Jorge Wagensberg
Any discipline of human knowledge is characterized by three fundamental elements: the complexity of its content, the method used for its elaboration, and the language used for its expression. This article argues that any method for making k...
Brett Calcott,Arnon Levy,Mark L Siegal et al.
Brett Calcott et al.
Biologists frequently draw on ideas and terminology from engineering. Evolutionary systems biology-with its circuits, switches, and signal processing-is no exception. In parallel with the frequent links drawn between biology and engineering...
Maureen A O&#x;Malley,Orkun S Soyer,Mark L Siegal
Maureen A O&#x;Malley
Evolutionary systems biology (ESB) is an emerging hybrid approach that integrates methods, models, and data from evolutionary and systems biology. Drawing on themes that arose at a cross-disciplinary meeting on ESB in 2013, we discuss in de...
Johannes Jaeger,Manfred Laubichler,Werner Callebaut
Johannes Jaeger
In a recent opinion piece, Denis Duboule has claimed that the increasing shift towards systems biology is driving evolutionary and developmental biology apart, and that a true reunification of these two disciplines within the framework of e...
John Huss
John Huss
Research on the human microbiome has generated a staggering amount of sequence data, revealing variation in microbial diversity at the community, species (or phylotype), and genomic levels. In order to make this complexity more manageable a...