miR-122 Inhibits Hepatocarcinoma Cell Progression by Targeting LMNB2 [0.03%]
miR-122通过靶向LMNB2抑制肝癌细胞的进展
Xiao-Na Li,Hong Yang,Tao Yang
Xiao-Na Li
In the present study, we investigated the role of miR-122 in hepatocarcinoma progression and explored the mechanism. In hepatocarcinoma tissues and cells, we used qRT-PCR to validate the miR-122 expression level. Next, we used colony format...
Overexpression of the Long Noncoding RNA FOXD2-AS1 Promotes Cisplatin Resistance in Esophageal Squamous Cell Carcinoma Through the miR-195/Akt/mTOR Axis [0.03%]
长非编码RNA FOXC2-AS1通过miR-195/Akt/mTOR轴促进顺铂耐药在食管鳞癌中的过表达作用研究
Huasong Liu,Jun Zhang,Xiangyu Luo et al.
Huasong Liu et al.
Emerging evidence has demonstrated that long noncoding RNAs (lncRNAs) mediate the development of esophageal squamous cell carcinoma (ESCC) via various pathophysiological pathways. This study explored the impact of the lncRNA FOXD2-AS1 on ci...
Loss of Fingerprints as a Side Effect of Capecitabine Therapy: Case Report and Literature Review [0.03%]
卡培他滨治疗的副作用——指纹丢失：病例报告和文献回顾
Jian Zhao,Xia Zhang,Xiaonan Cui et al.
Jian Zhao et al.
Hand-foot syndrome (HFS) is the main side effect of capecitabine and affects the compression zones of the body such as the palms and soles, causing numbness, paresthesias, skin swelling or erythema, scaling, chapping, hard nodule-like blist...
Efficacy and Safety of Drug-Eluting Beads Transarterial Chemoembolization by CalliSpheres® in 275 Hepatocellular Carcinoma Patients: Results From the Chinese CalliSpheres® Transarterial Chemoembolization in Liver Cancer (CTILC) Study [0.03%]
载药微球TACE治疗275例肝细胞癌患者的有效性和安全性：中国康博支TM经导管动脉化疗栓塞治疗原发性肝癌(CTILC)研究结果
Junhui Sun,Guanhui Zhou,Xiaoxi Xie et al.
Junhui Sun et al.
The purpose of this study was to investigate the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) treatment in Chinese hepatocellular carcinoma (HCC) patients and the prognostic factors for treatment resp...
Clinical Trial
Oncology research. 2020 Feb 7;28(1):75-94. DOI:10.3727/096504019X15662966719585 2020
The lncRNA FEZF1-AS1 Promotes the Progression of Colorectal Cancer Through Regulating OTX1 and Targeting miR-30a-5p [0.03%]
长链非编码RNA FEZF1-AS1通过调控OTX1和靶向miR-30a-5p促进结直肠癌进展
Jing Li,Lian-Mei Zhao,Cong Zhang et al.
Jing Li et al.
Long noncoding RNAs (lncRNAs) participate in and regulate the biological process of colorectal cancer (CRC) progression. Our previous research identified differentially expressed lncRNAs in 10 CRC tissues and 10 matched nontumor tissues by ...
Profilin 2 Promotes Proliferation and Metastasis of Head and Neck Cancer Cells by Regulating PI3K/AKT/β-Catenin Signaling Pathway [0.03%]
profilin 2通过调节PI3K/AKT/β-catenin信号转导促进头颈癌细胞增殖和转移
Kecheng Zhou,Jie Chen,Jiayu Wu et al.
Kecheng Zhou et al.
Profilin 2 (PFN2) was found to be mainly expressed in neurons and involved in the development of the brain. In recent years, emerging evidence indicated that PFN2 is also significantly upregulated in various cancers including head and neck ...
miR-186 Suppresses the Progression of Cholangiocarcinoma Cells Through Inhibition of Twist1 [0.03%]
miR-186通过抑制Twist1抑制胆管癌细胞的增殖
Ming Zhang,Baochang Shi,Kai Zhang
Ming Zhang
Deregulation of miR-186 and Twist1 has been identified to be involved in the progression of multiple cancers. However, the detailed molecular mechanisms underlying miR-186-involved cholangiocarcinoma (CCA) are still unknown. In this study, ...
CRISPR/Cas9-Mediated Gene Knockout of ARID1A Promotes Primary Progesterone Resistance by Downregulating Progesterone Receptor B in Endometrial Cancer Cells [0.03%]
利用CRISPR/Cas9介导的ARID1A基因敲除通过下调孕激素受体B促进子宫内膜癌细胞原发性孕酮耐药性
Haizhen Wang,Zhenghua Tang,Ting Li et al.
Haizhen Wang et al.
Medroxyprogesterone (MPA) is used for the conservative treatment of endometrial cancer. Unfortunately, progesterone resistance seriously affects its therapeutic effect. The purpose of the current study was to investigate the influence of de...
Reactive Oxygen Species-Mediated Cezanne Inactivation by Oxidation of its Catalytic Cysteine Residue in Hepatocellular Carcinoma [0.03%]
肝癌中活性氧介导的通过氧化其催化半胱氨酸残基使CEZANNE失活
Zhongyuan Yin,Lin Yang,Feng Wu et al.
Zhongyuan Yin et al.
Cysteine oxidation occurs at the active site of deubiquitinases (DUBs) during many biologic signaling cascades. Here we report that hepatocellular carcinoma cells (HCCs) generated higher levels of endogenous reactive oxygen species (ROS). T...
Triptolide Inhibits Breast Cancer Cell Metastasis Through Inducing the Expression of miR-146a, a Negative Regulator of Rho GTPase [0.03%]
三萜化合物Triptolide通过诱导microRNA-146a表达抑制乳腺癌转移
Qin Liu,Wei Wang,Fangqiong Li et al.
Qin Liu et al.
Triptolide, an extract of Tripterygium wilfordii, has been shown to have a potent anticancer activity. In the present study, it was found that triptolide could effectively induce apoptosis and inhibit proliferation and invasion in malignant...