Inhibition of Proliferation by Knockdown of Transmembrane (TMEM) 168 in Glioblastoma Cells via Suppression of Wnt/β-Catenin Pathway [0.03%]
通过抑制Wnt/β-catenin途径下调跨膜(TMEM)168基因能抑制胶质母细胞瘤细胞增殖
Jie Xu,Zhongzhou Su,Qiuping Ding et al.
Jie Xu et al.
Human glioblastoma multiforme (GBM) accounts for the majority of human brain gliomas. Several TMEM proteins, such as TMEM 45A, TMEM 97, and TMEM 140, are implicated in human brain gliomas. However, the roles of TMEM168 in human GBM remain p...
Anticancer Effects of Gleditsia sinensis Extract in Rats Transplanted With Hepatocellular Carcinoma Cells [0.03%]
刺槐提取物的抗肿瘤作用及机制研究
Yue Cai,Chizhi Zhang,Lei Zhan et al.
Yue Cai et al.
The thorns of Gleditsia sinensis have been historically used in Chinese medicine and are considered one of the fundamental therapeutic herbs. Its anticancer effects are currently being explored. Hepatocellular carcinoma (HCC) is the most co...
Extracellular S100A11 Plays a Critical Role in Spread of the Fibroblast Population in Pancreatic Cancers [0.03%]
细胞外S100A11在胰腺癌纤维母细胞播散中起关键作用
Hitoshi Takamatsu,Ken-Ichi Yamamoto,Nahoko Tomonobu et al.
Hitoshi Takamatsu et al.
The fertile stroma in pancreatic ductal adenocarcinomas (PDACs) has been suspected to greatly contribute to PDAC progression. Since the main cell constituents of the stroma are fibroblasts, there is crosstalking(s) between PDAC cells and su...
miR-374a Inhibitor Enhances Etoposide-Induced Cytotoxicity Against Glioma Cells Through Upregulation of FOXO1 [0.03%]
mir-374a抑制剂通过上调FOXO1增强鬼臼毒素对胶质瘤细胞毒性的研究
Wei Ni,Lin Luo,Ping Zuo et al.
Wei Ni et al.
Glioma is a commonly diagnosed brain tumor that shows high mortality rate. Despite the great advancement of cancer therapy in recent years, chemotherapy is still an important approach for treatment of glioma. However, long-term chemotherapy...
PAR2 Inhibition Enhanced the Sensitivity of Colorectal Cancer Cells to 5-FU and Reduced EMT Signaling [0.03%]
抑制PAR2可增强结直肠癌细胞对5-氟尿嘧啶的敏感性并减少EMT信号转导
Qiuying Quan,Fengyun Zhong,Xinwei Wang et al.
Qiuying Quan et al.
The aim of this study was to investigate the underlying mechanisms that transforming growth factor-β (TGF-β)-mediated epithelial-to-mesenchymal transition (EMT) in tumor cells contributes to 5-FU resistance. A series of experiments involv...
miR-101 Represses T-Cell Acute Lymphoblastic Leukemia by Targeting CXCR7/STAT3 Axis [0.03%]
微小核糖核酸-101通过靶向CXCR7/STAT3轴抑制T细胞急性淋巴细胞白血病
Xue-Yi Yang,Ye Sheng
Xue-Yi Yang
Although miR-101 is involved in the development and progression of T-cell acute lymphoblastic leukemia (T-ALL), the underlying molecular mechanisms remain unclear. In this article, we report that miR-101 expression was inversely correlated ...
miR-203 Inhibits the Invasion and EMT of Gastric Cancer Cells by Directly Targeting Annexin A4 [0.03%]
microRNA-203通过直接靶向胞质分化抗原Annexin A4抑制胃癌细胞侵袭及上皮间质转化现象的研究
Jianye Li,Bin Zhang,Jizhao Cui et al.
Jianye Li et al.
Many studies have shown that downregulated miR-203 level is in a variety of cancers including gastric cancer (GC). However, the precise molecule mechanisms of miR-203 in GC have not been well clarified. In the current study, we investigated...
Synergistic Efficacy of the Demethylation Agent Decitabine in Combination With the Protease Inhibitor Bortezomib for Treating Multiple Myeloma Through the Wnt/β-Catenin Pathway [0.03%]
DNA去甲基化药物地西他滨联合蛋白酶体抑制剂硼替佐米协同治疗多发性骨髓瘤的分子机制：作用于Wnt/β-catenin信号通路
Yulong Jin,Li Xu,Xiaodong Wu et al.
Yulong Jin et al.
Multiple myeloma (MM) is a hematopoietic malignancy characterized by the clonal proliferation of antibody-secreting plasma cells. Bortezomib (BZM), the first FDA-approved proteasome inhibitor, has significant antimyeloma activity and prolon...
Knockdown of IARS2 Inhibited Proliferation of Acute Myeloid Leukemia Cells by Regulating p53/p21/PCNA/eIF4E Pathway [0.03%]
IARS2敲低通过调控p53/p21/PCNA/eIF4E通路抑制急性髓系白血病细胞增殖
Hong Li,Yaning Tian,Xiang Li et al.
Hong Li et al.
IARS2 encodes mitochondrial isoleucine-tRNA synthetase, which mutation may cause multiple diseases. However, the biological function of IARS2 on acute myeloid leukemia (AML) has not yet been identified. In the present study, qRT-PCR was use...
Nutlin-3-Induced Sensitization of Non-Small Cell Lung Cancer Stem Cells to Axitinib-Induced Apoptosis Through Repression of Akt1/Wnt Signaling [0.03%]
Nutlin-3通过抑制Akt1/Wnt信号传导使非小细胞肺癌干细胞对Axitinib诱导的凋亡敏感
Meng Wang,Xin Wang,Yuan Li et al.
Meng Wang et al.
The aim of this study was to investigate the potential biological activities of nutlin-3 in the regulation of growth and proliferation of non-small cell lung cancer (NSCLC) stem cells (CSCs), which may help in sensitizing to axitinib-induce...