Identification of BRCA2 Likely Germline Pathogenic Variants in Patients with Multiple Primary Lung Adenocarcinomas [0.03%]
BRCA2可能的生殖系致病突变与多原发肺腺癌患者的临床病理特征相关性研究
Dat Quoc Tran,Mayu Takeda,Eiji Sugihara et al.
Dat Quoc Tran et al.
Objectives: Genetic risk models have substantially advanced our understanding of germline pathogenic variants (GPVs) in some malignancies, whereas their clinical significance in lung cancer remains unclear. The present study aimed to better...
Clinical Applications of CDK4/6 Inhibitors in HR+/HER2, and Personalized Treatment Strategies: A Narrative Review [0.03%]
cyclin依赖性激酶4和6在HR+/HER2乳腺癌中的临床应用及个体化治疗策略：叙述性综述
Guoliang Zhong,Tianqing Yang,Shuqi Lin et al.
Guoliang Zhong et al.
Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2-negative (HR+/HER2-) breast cancer treatment has made a breakthrough due to the introduction of cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors. This article mainly rev...
Exploring Novel E3 Ligases and Neosubstrates for Molecular Glue Degraders and Therapeutic Applications in Cancer [0.03%]
探索新型E3连接酶和 neo-底物用于分子胶降解剂及癌症治疗应用中的研究
Ji Hoon Jang,Joo-Young Kim,Tae-Jin Lee
Ji Hoon Jang
Molecular glue degraders (MGDs) are an emerging class of small molecules that promote selective protein degradation by inducing neomorphic interactions between E3 ubiquitin ligases and non-native substrates, referred to as neosubstrates. Cl...
CHK1 as a Metabolic and Immunological Regulator: Implications for Cancer Therapy [0.03%]
CHK1作为代谢和免疫调节因子在癌症治疗中的作用
Maria Franza,Aurora Melfi,Filippo Acconcia et al.
Maria Franza et al.
Checkpoint kinase 1 (CHK1), a key regulator of cell cycle checkpoints, plays a central role in the DNA damage response network, serving as a critical mediator that links DNA damage detection to DNA repair mechanisms. In recent years, severa...
Neurotransmitter-Mediated Signaling in Glioblastoma and Glial Tumors: Biology and Therapeutic Opportunities [0.03%]
胶质瘤和神经胶质肿瘤中的神经递质介导信号通路的生物学特性及其治疗价值
Pietro Tralongo,Mariagiovanna Ballato,Valeria Zuccalà et al.
Pietro Tralongo et al.
Glioblastoma (GB) is the most common primary malignant brain tumor of adulthood, and despite optimal safe resection and chemoradiation, it is still lethal. Neuroscience of cancer has shown that neuronal activities, as well as neurotransmitt...
Retraction: Long Noncoding RNA CRNDE Promotes Multiple Myeloma Cell Growth by Suppressing miR-451 [0.03%]
撤稿：长链非编码RNA CRNDE通过抑制miR-451促进多发性骨髓瘤细胞增殖
Oncology Research Editorial Office
Oncology Research Editorial Office
[This retracts the article DOI: 10.3727/096504017X14886679715637.]. © 2026 The Author. Published by Tech Science Press.
Metal-Based Therapeutic Approaches for Overcoming Cancer Drug Resistance: Mechanisms, Drug Delivery Strategies, and Clinical Perspectives [0.03%]
基于金属的克服癌症药物耐受性的治疗策略：机理、药物输送策略和临床观点
Kirill V Chernov,Artemii M Savin,Daria E Otvodnikova et al.
Kirill V Chernov et al.
The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug...
Baclofen Inhibits Glioma Proliferation via the MEK/ERK/CREB Pathway [0.03%]
巴氯芬通过MEK/ERK/CREB途径抑制胶质瘤增殖
Boqi Zhou,Liping Shen,Xiaojie Lu
Boqi Zhou
Objectives: Gamma-aminobutyric acid type B (GABAB) receptors are involved in tumor progression, and baclofen exerts broad-spectrum antitumor effects in various cancers. Nevertheless, its specific function and underlying molecular mechanisms...
EZH2 in Acral Lentiginous Melanoma: Molecular, Epigenetic, and Therapeutic Perspectives [0.03%]
肢端雀斑样黑色素瘤中的EZH2：分子、表观遗传及治疗学观点
Daniel Arcuschin de Oliveira,Melissa Yoshimi Sakamoto Maeda Nisimoto,Jaciara Moreira Sodré Hunnicutt et al.
Daniel Arcuschin de Oliveira et al.
Acral lentiginous melanoma (ALM) is characterized by a low mutational burden, frequent chromosomal rearrangements, and profound epigenetic dysregulation, distinguishing it from ultraviolet (UV)-induced melanoma. Among the epigenetic regulat...
Polypharmacy in Elderly Patients Receiving First-Line Treatment for Pancreatic Adenocarcinoma: Analysis of Potential Drug-Drug Interactions and Outcome [0.03%]
老年胰腺导管腺癌一线治疗患者多重用药分析及其潜在的药物相互作用和预后研究
Stefano Vecchia,Rebecca Chinelli,Arianna Orcesi et al.
Stefano Vecchia et al.
Objectives: Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality and mainly affects older adults, who frequently experience polypharmacy. While systemic therapy may improve outcomes in selected older patien...