Microbiome and Response to Therapy in Triple Negative Breast Cancer: A Systematic Review [0.03%]
三阴性乳腺癌的微生物组和治疗反应：系统评价研究
Mariana Lopes,Carlos Vila Nova,Rui Caetano Oliveira et al.
Mariana Lopes et al.
Objectives: Triple-negative breast cancer (TNBC) accounts for approximately 15% of all invasive breast cancers and is characterized by aggressive behavior, limited therapeutic options, and poor clinical outcomes. Due to the absence of hormo...
Clinical Value of the Systemic Immune Inflammation Index and PD-L1 Expression in Advanced NSCLC Treated with Pembrolizumab: Real-World Preliminary Study [0.03%]
程序性死亡配体1表达和系统免疫炎症指数在帕博利珠单抗治疗晚期非小细胞肺癌中的临床价值：真实世界初步研究
Hyungkeun Cha,Yong Seok Lee,Gui Young Kwon et al.
Hyungkeun Cha et al.
Objective: Studies on the comprehensive utility of complete blood count-derived inflammatory biomarkers (CBC-IBs) as biomarkers in pembrolizumab-treated advanced non-small-cell lung cancer (NSCLC) are scarce. This study aimed to investigate...
UCK2 Drives Lung Adenocarcinoma Progression and Immune Dysregulation via the RHEB/mTOR Signaling Axis [0.03%]
UCK2通过RHEB/mTOR信号轴驱动肺腺癌进展和免疫失调
Xiaolin Wei,Jing Guo,Chuntao Tao et al.
Xiaolin Wei et al.
Objectives: Uridine-cytidine kinase 2 (UCK2) plays a crucial role in the pyrimidine salvage pathway, but its function in lung adenocarcinoma (LUAD) is still largely unclear. The study aimed to investigate the expression, prognostic value, b...
Repurposing Artesunate to Combat Progression and Metastasis via Targeting Circulating Tumor Cells [0.03%]
通过靶向循环肿瘤细胞再利用 Arteunate 来对抗癌症的发展和转移
Evangelia Pantazaka,Dimitrios Papakonstantinou,Argyro Roumeliotou et al.
Evangelia Pantazaka et al.
Objectives: Circulating tumor cells (CTCs) drive metastasis and exhibit resistance to conventional therapies, making them crucial therapeutic targets. Artesunate (AS), a derivative of artemisinin, displays anticancer activity, including inh...
After a Decade of Therapy Revolution in Cutaneous Melanoma-Perspectives on Emerging Treatment Strategies [0.03%]
皮肤黑色素瘤治疗革命的十年——展望新兴治疗策略的观点
Sebastian A Wohlfeil,Jochen S Utikal
Sebastian A Wohlfeil
Over the past decade, the therapeutic paradigm of cutaneous melanoma has been transformed strongly, driven by advances in immuno-oncology and precision medicine. Building on the success of immune checkpoint blockade and targeted therapy, ne...
Ethnic Disparities in Glioblastoma Markers: Impact of Chromosome 7 Gain and 10 Loss Alterations on Clinical Survival Outcomes [0.03%]
染色体7增多和10号染色体丢失的改变对临床预后影响胶质母细胞瘤标志物的民族差异
Fang-Ying Chiu,Yun Yen
Fang-Ying Chiu
Objective: Glioblastoma (GBM) is the most common primary malignant brain tumor and is characterized by significant intratumoral heterogeneity. This study aimed to investigate the clinical and genomic landscapes of GBM across diverse ethnic ...
Germline Predisposition in Pediatric Central Nervous System Tumors: Insights from a Multigene Panel Study [0.03%]
儿童中枢神经系统肿瘤的遗传易感性：来自多基因 panel 研究的见解
Meerim Park,Seungman Park,Ensel Oh et al.
Meerim Park et al.
Objectives: Germline variants in cancer predisposition genes have been increasingly recognized in pediatric cancers. However, their spectrum in East Asian children with central nervous system (CNS) tumors remains insufficiently defined. Thi...
Claudin 18.2 Expression in Gastric Adenocarcinoma: Diagnostic Reproducibility and Clinicopathologic Associations in A Western Cohort [0.03%]
Claudin 18.2在胃腺癌中的表达：西方人群的诊断再现性及临床病理特征关联研究
Cristina Díaz Del Arco,Luis Ortega Medina,Patricia Barreiro Sanabria et al.
Cristina Díaz Del Arco et al.
Background: Claudin 18.2 (CLDN18.2) has become a clinically relevant therapeutic target in gastric adenocarcinoma (GC), with zolbetuximab now approved for use in CLDN18.2-positive, HER2-negative advanced disease. The aim of this study was t...
Claudin-1 Interacts with CD81 and Promotes the Progression of Colorectal Cancer [0.03%]
Claudin-1与CD81相互作用并促进结直肠癌的发展
Kaidi Yin,Lili Deng,Wen Liu
Kaidi Yin
Objectives: Although claudin-1 (CLDN1) interacts with Cluster of Differentiation 81 (CD81) in various cell types, the specific mechanism underlying this interaction and its functional implications in colorectal cancer (CRC) cells remain poo...
Multi-Omics and Single-Cell Dissection Reveals EXT1 as a Glycosylation-Linked Therapeutic Target in Cancer [0.03%]
多组学和单细胞分析揭示EXT1为癌症中的糖基化相关治疗靶点
Wen-Hsin Hsu,Kai-Fu Chang,Chih-Hsuan Chang et al.
Wen-Hsin Hsu et al.
Background: Glycosylation and inflammation are pivotal in tumor progression, yet the specific glycosyltransferases bridging these processes remain poorly defined. This study investigated Exostosin-1 (EXT1), a key enzyme in heparan sulfate (...