INHBA Promotes the Progression of Gastric Cancer by Activating MAPK Signaling Pathway via Targeting ITGA6 [0.03%]
INHBA通过靶向ITGA6激活MAPK信号通路促进胃癌进展
Guojian Zhou,Rui Zhang,Lei Nie et al.
Guojian Zhou et al.
Objectives: Gastric cancer (GC) is among the most prevalent malignancies worldwide, ranking as the fifth most common cancer and the fifth leading cause of cancer-related mortality. This study intends to investigate how In...
TDO2-Associated Tryptophan Metabolism Correlates with Impaired Tertiary Lymphoid Structure Maturation and Reduced B Cell Class Switching in Breast Cancer [0.03%]
乳腺癌中与TDO2相关的色氨酸代谢与三级淋巴组织成熟缺陷和B细胞类别转换减少相关性研究
Weiping Yang,Wei Xiao,Wenhao Xu et al.
Weiping Yang et al.
Background: Tertiary lymphoid structures (TLSs) promote antitumor immunity and predict favorable immunotherapy outcomes in breast cancer. The study aimed to investigate how Tryptophan 2,3-dioxygenase (TDO2)-associated try...
FOXA2 as a SETD1A-Regulated Driver of Tamoxifen Resistance in Breast Cancer [0.03%]
SETD1A调控的乳腺癌他莫昔芬耐药驱动基因FOXA2
Myeong Ryeo Kim,Jae Rim Lee,Xiaohan Zhang et al.
Myeong Ryeo Kim et al.
Objectives: Tamoxifen is a key drug that provides endocrine therapy for estrogen receptor (ER) α-positive breast cancer; however, resistance remains a significant clinical challenge. This study aims to investigate the mo...
DNASE1L3 Mediates Hepatocellular Carcinoma Tumor Growth and Organoid Models via the Wnt/ β-Catenin Signaling Pathway [0.03%]
DNA酶I样蛋白3通过Wnt/β-catenin信号通路介导肝癌肿瘤生长和类器官模型
Shulong Zhang,Yijun Zhao,Li Geng et al.
Shulong Zhang et al.
Background: Hepatocellular carcinoma (HCC) is a highly lethal malignancy driven by both intrinsic oncogenic pathways and immune microenvironmental regulation. Emerging evidence suggests that DNASE1L3 may influence tumor b...
Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Locally Advanced Rectal Cancer Treated with Neoadjuvant Concurrent Chemoradiotherapy and Robotic-Assisted Resection [0.03%]
新辅助同期放化疗和机器人辅助切除治疗局部晚期直肠癌的预后价值：血清中性粒细胞与淋巴细胞比值的作用
Yen-Cheng Chen,Tsung-Kun Chang,Wei-Chih Su et al.
Yen-Cheng Chen et al.
Background: The long-term outcomes of robotic-assisted surgery and the prognostic significance of the pretreatment neutrophil-to-lymphocyte ratio (NLR) in locally advanced rectal cancer (LARC) remain uncertain. This study...
The Neuroimmune Axis in Gastric Cancer: Bridging Neural Regulation, Tumor Microenvironment, and Immunotherapy [0.03%]
胃癌的神免疫轴：神经调控、肿瘤微环境与免疫治疗之间的桥梁
Fangyuan Zhang,Xi Wang,Xinxin Shen et al.
Fangyuan Zhang et al.
Accumulating evidence indicates that the neuro-immune axis is central to gastric cancer pathogenesis. Dynamic, bidirectional signaling between neural circuits and immune cells promotes tumor progression, shapes an immunosuppressive microenv...
The Role of the Gut Microbiome in Clinical Outcomes of Colorectal Cancer: A Systematic Review (2020-2025) [0.03%]
肠道菌群在结直肠癌临床结局中的作用（2020-2025）系统综述
Iara Santos,Joana Liberal,Paulo Teixeira et al.
Iara Santos et al.
Background: The Colorectal Cancer (CRC) pathogenesis and therapeutic efficacy are influenced by the gut microbiome, making it a promising biomarker for predicting treatment responses and adverse effects. This systematic r...
Research on the Mechanism of "Cold Tumor" Formation and Immunotherapy for Its Transformation into "Hot Tumor" [0.03%]
冷肿瘤形成机制及转化为热肿瘤的免疫治疗研究
Liang Zhou,Jia Zhou,Zhengyi Wang
Liang Zhou
A clear goal in cold tumor research is to identify strategies for converting them into immunologically 'hot' tumors with enhanced immune cell infiltration and activity, thereby improving their responsiveness to immunotherapy. The genesis of...
Put the CAR-T before the HRS: Advances in Anti-CD30 Immunotherapy Targeting Hodgkin/Reed-Sternberg Cells in Classical Hodgkin Lymphoma [0.03%]
CAR-T在HRS细胞之前：经典霍奇金淋巴瘤中针对HRS细胞的抗CD30免疫治疗进展
Yuriy Mayasin,Maria Osinnikova,Daria Osadchaya et al.
Yuriy Mayasin et al.
Classical Hodgkin lymphoma (cHL) is characterized by rare Hodgkin/Reed-Sternberg (HRS) tumor cells that uniformly express cluster of differentiation (CD)30 molecules and orchestrate an immunosuppressive tumor microenvironment, making CD30 a...
Effect of Photosensitiser Chlorin E6 on Cancerous Bone Tumor Cells Using Photodynamic Therapy [0.03%]
光动力疗法中光敏剂血啉E6对骨肿瘤癌细胞的影响研究
Frank Traub,Muhammad A Panezai,Michaela Moisch et al.
Frank Traub et al.
Objectives: Photodynamic therapy (PDT) is a minimally invasive method used in the treatment of various cancers and skin diseases, but it is not widely used in bone cancer, where the current therapy is often not effective ...