Factors Affecting the Efficacy and Safety of First-Line Anti-PD-1 Therapy in Advanced Non-Small Cell Lung Cancer [0.03%]
影响晚期非小细胞肺癌一线抗PD-1治疗疗效和安全性的因素分析
Zhen Wang,Qian Xie,Yu Luo et al.
Zhen Wang et al.
Objective: This study assesses peripheral blood parameters as predictors of programmed cell death protein-1 (PD-1) inhibitor efficacy in advanced non-small cell lung cancer (NSCLC). Methods: We retrospectively analyzed 169 advanced NSCLC pa...
A New Paradigm of Bispecific Antibodies in Clinical Management of Gastrointestinal Cancers [0.03%]
双特异性抗体在胃肠肿瘤临床治疗中应用的新范式
Huimin Zhao,Xiuran Wang,Zhimeng Fan et al.
Huimin Zhao et al.
Gastrointestinal (GI) cancers represent a significant global health burden, characterized by high incidence, poor prognosis, and limited response to monotherapies. The advent of bispecific antibodies (BsAbs) has introduced a novel therapeut...
Germinal Center-Like Tertiary Lymphoid Structures Mark Immune Responsiveness and Enable Checkpoint Immunotherapy in Bladder Cancer [0.03%]
类似生发中心的三级淋巴组织结构可作为膀胱癌免疫反应的标志并介导免疫检查点治疗的效果
Zhihao Yin,Xi Zhen,Haonan Li et al.
Zhihao Yin et al.
Backgrounds: Tertiary lymphoid structures (TLSs) are increasingly recognized as modulators of anti-tumor immunity, yet their clinical relevance in bladder cancer remains incompletely understood, partly owing to heterogeneity in their matura...
Single-Cell Sequencing Reveals the Heterogeneity of Glioma and Identifies IGFBP2 as A Potential Therapeutic Target [0.03%]
单细胞测序揭示胶质瘤的异质性并鉴定出IGFBP2作为潜在治疗靶点
Jian-Lei Kang,Yu-Jie Xu,Qi-Tai Zhao et al.
Jian-Lei Kang et al.
Background: Glioma is among the most malignant brain tumors, and its heterogeneity contributes significantly to treatment failure. Comprehensive profiling of cellular and molecular heterogeneity across different glioma stages and recurrence...
Emerging Approaches in Breast Cancer: From Molecular Mechanisms to Diagnosis and Therapeutic Strategies [0.03%]
乳腺癌的新方法：从分子机制到诊断和治疗策略
Raquel Sanchez-Baltasar,Nerea Castañeda-Fernández,Jorge Olivares-Arancibia et al.
Raquel Sanchez-Baltasar et al.
Breast cancer (BC) is the most frequently diagnosed malignancy in women worldwide and remains one of the leading causes of cancer-related mortality, with substantial international disparities in incidence, stage at diagnosis, access to trea...
PARP9 Modulates Sunitinib Resistance in Clear Cell Renal Cell Carcinoma via STAT1/ IRF1 Signaling Pathway [0.03%]
PARP9通过STAT1/IRF1信号通路调节透明细胞肾细胞癌对苏尼替尼的耐药性
Lei Luo,Fengju Guan,Zhankun Wang et al.
Lei Luo et al.
Background: Resistance to sunitinib represents a major clinical obstacle in the management of clear cell renal cell carcinoma (ccRCC). This investigation aims to identify genes associated with sunitinib resistance and elucidate potential mo...
Integrative Analysis of Glycosylation-Related Genes Reveals Prognostic Subtypes, Immune Evasion, and Therapeutic Vulnerabilities in Lung Adenocarcinoma [0.03%]
整合分析糖基化相关基因揭示肺腺癌预后亚型、免疫逃逸及治疗弱点
Yu-Wei Liu,Yung-Kuo Lee,Kai-Fu Chang et al.
Yu-Wei Liu et al.
Background: Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer (NSCLC) and remains a leading cause of cancer-related mortality worldwide. Aberrant glycosylation contributes to tumor progression by regulating...
Resveratrol in Oral Squamous Cell Carcinoma: Preclinical Evidence and Translational Opportunities [0.03%]
白藜芦醇在口腔鳞癌中的研究证据和转化机遇
Alessandro Polizzi,Gaetano Isola,Monia Cecati et al.
Alessandro Polizzi et al.
Polyphenolic stilbenes are plant-derived compounds that have attracted increasing interest for their potential anticancer properties. Among them, resveratrol is the most extensively investigated molecule. Oral squamous cell carcinoma (OSCC)...
Julia Banaszkiewicz,Paweł Krawczyk,Tomasz Grenda et al.
Julia Banaszkiewicz et al.
Unfavorable epidemiological forecasts indicating a significant increase in cancer incidence and mortality, as well as limitations of traditional cancer treatment methods, prompt the search for new, more effective therapeutic strategies. In ...
Alessandro Poggi
Alessandro Poggi
The production of murine monoclonal antibodies (mAbs) with defined specificity in 1975 marked the subsequent revolution of cancer therapy. mAbs have been essential to characterize the functional features of molecules involved in cancer cell...