Primary Debulking Surgery Versus Neoadjuvant Chemotherapy in Advanced Ovarian Cancer: A Meta-Analysis of All Randomized Clinical Trials with Subgroup Analysis by Patient Profile [0.03%]
晚期卵巢癌初始手术与新辅助化疗的 meta 分析及亚组分析：按患者状况分层
Carlo Ronsini,Giuseppe Cucinella,Maria Cristina Solazzo et al.
Carlo Ronsini et al.
Background: The optimal sequencing of surgery and chemotherapy in advanced epithelial ovarian cancer remains debated. While primary debulking surgery (PDS) has been considered the standard approach, recent randomized tria...
PSMD2-Mediated MAPK Signaling Promotes Bladder Cancer Development and Immune Microenvironment Remodeling [0.03%]
PSMD2介导的MAPK信号促进膀胱癌发生及免疫微环境重塑
Shuwen Sun,Jingcheng Zhang,Zongtai Zheng et al.
Shuwen Sun et al.
Objectives: Bladder cancer (BCa) progression is closely linked to the immune microenvironment. However, the key molecules that regulate this microenvironment and their specific mechanisms remain poorly understood. This st...
Maureen Veilleux,Anh Nguyen,Charles Cao et al.
Maureen Veilleux et al.
ADP-ribosyltransferases (ARTs) regulate key processes in cancer, including DNA repair, transcription, immune responses, and treatment resistance. The clostridial toxin-like ADP-ribosyltransferase (ARTC) family and the diphtheria toxin-like ...
Cytokines IL-6, IL-10, and CCL5 Secreted by Infiltrating B Cells Promote Cell Migration of Human Prostate Cancer Cell Lines [0.03%]
浸润B细胞分泌的白细胞介素-6、白细胞介素-10和CCL5促进人前列腺癌细胞系迁移
Crystal J Byrd,Monasia Evans,Woojung Kim et al.
Crystal J Byrd et al.
Objective: The progression of prostate cancer cells to metastasis is supported by their tumor microenvironment. Within this microenvironment, infiltrating immune cells, such as B cells, can be either anti-tumorigenic or p...
Multi-Scale Transcriptomic Sequencing Data Analysis Reveals LINC00467 is Associated with Malignant Progression in Breast Cancer: An In Silico and In Vitro Study [0.03%]
多尺度转录组测序数据分析揭示长链非编码RNA LINC00467与乳腺癌恶性进展相关：基于生物信息学和实验的联合研究
Hui Zha,Chao Li,Jia Chen et al.
Hui Zha et al.
Objective: Long non-coding RNAs have been found to play a pivotal role in breast cancer, yet the majority of these lncRNAs remain to be thoroughly investigated. This study aimed to explore the role of differentially expre...
Adolescent Renal Tumours: Diagnostic and Therapeutic Challenges in a Transitional Age Group-A Multidisciplinary Case Report Series from a Single Center [0.03%]
青少年肾肿瘤：一个过渡年龄段的诊断和治疗挑战——单中心多学科病例报告系列
Antonio Ruggiero,Fernando Fuccillo,Valerio Di Paola et al.
Antonio Ruggiero et al.
Background: The management of renal neoplasms in adolescent patients poses unique clinical challenges due to their transitional position between paediatric and adult populations. This age group exhibits marked heterogenei...
Case Reports
Oncology research. 2026 Mar 23;34(4):36. DOI:10.32604/or.2026.072807 2026
Sunitinib and Fenofibrate as Combination Therapy for MDR Glioblastoma: Insights from In Vitro and In Silico Studies [0.03%]
索拉非尼和非诺贝特作为难治性胶质母细胞瘤的联合治疗：来自体外和计算机模拟研究的见解
Saad Alobid,Hussam Albassam,Tebyan O Mirgany et al.
Saad Alobid et al.
Objective: Glioblastoma (GB) therapy is challenged by tumor heterogeneity and multidrug resistance (MDR), highlighting the need for effective therapies. This study aimed to explore the combined anticancer effects of Sunit...
KNL1 Regulates Ferroptosis Resistance and Migration in Lung Adenocarcinoma Cells via AMPK-mTOR Signaling [0.03%]
KNL1通过AMPK-mTOR信号调节肺腺癌细胞的铁死亡抵抗和迁移能力
Yiran Dong,Jingyue Wang,Jiayang Chen et al.
Yiran Dong et al.
Background: Lung adenocarcinoma (LUAD), the most prevalent histological subtype of lung cancer, remains a leading cause of cancer-related mortality due to late diagnosis, metastasis, and therapy resistance. The aim of the...
Comprehensive Bioinformatics Analysis and Experimental Verification RNF186 Is a Recurrence Signature Gene of Hepatocellular Carcinoma that Promotes Cell Proliferation [0.03%]
全面生物信息学分析和实验验证RNF186是促进细胞增殖的肝癌复发标志基因
Shanbao Ke,Junya Yan,Xiao Feng et al.
Shanbao Ke et al.
Objectives: Tumor recurrence is a major determinant of poor prognosis in hepatocellular carcinoma (HCC), yet its cellular and molecular basis remains incompletely understood. This study aimed to identify recurrence-associ...
Exploring Machine Learning Approaches for Decision Support in Neoadjuvant Therapy of Locally Advanced Rectal Cancer [0.03%]
探索机器学习在局部晚期直肠癌新辅助治疗决策支持中的方法
Eshita Dhar,Muhammad Ashad Kabir,Divyabharathy Ramesh Nadar et al.
Eshita Dhar et al.
Objectives: Decisions regarding CT after nCCRT for locally advanced rectal cancer (LARC) are challenging due to limited evidence guiding treatment. This study aimed to (i) evaluate the predictive performance of machine le...