SLC16A1 Activates the STAT3/SLC7A11 Pathway to Mediate Ferroptosis Resistance and Tumor Progression in Head and Neck Squamous Cell Carcinoma [0.03%]
SLC16A1通过激活STAT3/SLC7A11信号通路介导头颈部鳞状细胞癌的铁死亡抵抗和肿瘤进展
Chunhui Tian,Weipin Xie,Wen Li et al.
Chunhui Tian et al.
Background: In head and neck squamous cell carcinoma (HNSCC), solute carrier family 16 member 1 (SLC16A1) is associated with tumor advancement and reduced sensitivity to ferroptosis, yet the molecular basis of these effec...
Extrachromosomal DNA in Solid Tumors-Landscape, Immune Effects, and Resistance to Targeted Therapy [0.03%]
实体肿瘤中的细胞外染色体DNA：图谱、免疫效应和靶向治疗耐药性
Omar Badran,Siraj Attarya
Omar Badran
Extrachromosomal DNA (ecDNA) constitutes a principal factor in the amplification of oncogenes and the progression of tumors in solid malignancies. This review synthesizes emerging mechanistic, genomic, and immunologic evidence across multip...
The Real-World Endocrine Toxicity Profile of ICIs, VEGFR-TKIs, and Their Combination: Analysis of the FDA Adverse Event Reporting System (FAERS) Database [0.03%]
免疫检查点抑制剂、血管内皮生长因子受体酪氨酸激酶抑制剂及其联合治疗的现实世界内分泌毒性特征：对美国食品药品管理局不良事件报告系统数据库的分析
Nicola Marrano,Mariangela Caporusso,Cosimo Matino et al.
Nicola Marrano et al.
Background: Immune checkpoint inhibitors (ICIs) are a cornerstone of systemic therapy for renal cell carcinoma (RCC), used both in the adjuvant and metastatic settings across various lines of treatment, often in combinati...
Elevated C-Reactive Protein as a Potential Biomarker for Neurological Adverse Events in Immune Checkpoint Inhibitor Therapy: A Prospective Cohort Study [0.03%]
循环C-反应蛋白作为免疫检查点抑制剂相关神经毒性潜在生物标志物的前瞻性队列研究
Laura Duzzi,Nora Möhn,Emily Narten et al.
Laura Duzzi et al.
Objectives: Since 2011, immune checkpoint inhibitors (ICI) have transformed the treatment of various cancers. However, our understanding of the autoimmune adverse events, particularly those affecting the nervous system, r...
Kassiani Lalechou,Despoina Pantazi
Kassiani Lalechou
Cancer-associated thrombosis (CAT) is a leading cause of morbidity and mortality among cancer patients. While venous thromboembolic events have been extensively studied due to their higher incidence, arterial thrombosis in cancer patients-r...
Case Report: A Case of Neuroendocrine Carcinoma of the Endometrium with Deficient DNA Mismatch Repair Had Achieved Clinical Complete Response after Combination Therapy [0.03%]
病例报告：接受联合治疗后达临床完全缓解的错配修复缺陷型子宫内膜神经内分泌癌一例
Xie Ding,Xinfeng Liu,Cheng Dai et al.
Xie Ding et al.
Background: Immunotherapy has markedly reshaped the therapeutic landscape for patients with postoperative progression and metastasis. As a programmed death-1 (PD-1) inhibitor, camrelizumab has been proven to exhibit both ...
Case Reports
Oncology research. 2026 Apr 22;34(5):37. DOI:10.32604/or.2026.071213 2026
Integrated Global Phosphoproteomic, Bioinformatic, and Machine Learning Analysis Reveals Regulatory Networks of TOP1, TOP2A, TOP2B, and C1orf35 in Hepatocellular Carcinoma (HCC) [0.03%]
整合的全球磷酸蛋白质组学、生物信息学和机器学习分析揭示肝细胞癌（HCC）中TOP1、TOP2A、TOP2B和C1orf35的调控网络
Aktham Mestareehi
Aktham Mestareehi
Objective: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, largely due to late diagnosis, molecular heterogeneity, and limited prognostic biomarkers. Aberrant protein phosphorylati...
AI-Guided Discovery of Oncogenic Signaling Crosstalk in Tumor Progression and Drug Resistance [0.03%]
人工智能引导的肿瘤进展和药物抗性中的致癌信号交叉谈发现
Edward Sutanto,Rinni Sutanto,Sara Velichkovikj et al.
Edward Sutanto et al.
The rapid growth and accessibility of artificial intelligence (AI) and machine learning (ML) have opened many avenues to revolutionize biomedical research, particularly in oncogenesis. Oncogenesis is a hallmark process in the development of...
Data Mining for Identification of Targets and Repurposed Drugs to Eliminate Persistent Chronic Myeloid Leukaemia Stem Cells: Targeting RAS/RAF Signalling [0.03%]
数据挖掘鉴定靶标和重定位药物消除慢性髓性白血病持久性干细胞：靶向RAS/RAF信号通路
I Made Bayu Anggriawan,Heather G Jørgensen
I Made Bayu Anggriawan
Background: Persistent leukaemic stem cells (LSCs) in chronic myeloid leukaemia (CML) are insensitive to targeted tyrosine kinase inhibitors (TKIs). Identifying alternative molecular vulnerabilities may offer new therapeu...
Isoliquiritigenin Impedes Breast Cancer Progression through PITX1-PFKP-Mediated Glycolysis Reprogramming [0.03%]
isoliquiritigenin通过PITX1-PFKP介导的糖酵解重编程阻碍乳腺癌进展
Cong Liu,Zhenyu Zhang,Ronghua Feng et al.
Cong Liu et al.
Background: Breast cancer is the leading cause of cancer-related deaths in women, primarily due to distant metastasis. Metabolic reprogramming plays a critical role in tumor growth and spread, but the metabolic mechanisms...