CDCA7 Promotes Proliferation and Suppresses Apoptosis in Gastric Cancer via HELLS-Mediated Chromatin Remodeling [0.03%]
CDCA7通过HELLS介导的染色质重塑促进胃癌细胞增殖并抑制凋亡
Jun Jiang,Yi-Ran Li,Xiaoting Wang et al.
Jun Jiang et al.
Background: In various tumor types, cell division cycle-associated 7 (CDCA7) is involved in chromatin remodeling and DNA methylation. However, its biological functions and regulatory mechanisms in gastric cancer (GC) rema...
Mebendazole Attenuates Cellular Invasion in a 3D Culture Model of Meningioma by Disrupting Rho-GTPase-Mediated Microtubule Function [0.03%]
美苯达唑通过破坏Rho-GTP酶介导的微管功能来减弱脑膜瘤细胞侵袭能力：一种三维培养模型研究
Munro Matthew James,López Vásquez Clara Elena,Wickremesekera Agadha et al.
Munro Matthew James et al.
Objective: Meningioma is the most common primary brain tumour. Invasion into the brain is a diagnostic feature of grade II meningiomas and is associated with recurrence and poor prognosis. Mebendazole is a microtubule inh...
Identify MTDH as a Key Gene of Radio-Resistance in Colorectal Cancer Based on Multi-Omics and Experimental Validation [0.03%]
基于多组学和实验验证鉴定结直肠癌放射抵抗的关键基因MTDH
Wei Xu,Yuanyuan Zhang,Yizhi Ge et al.
Wei Xu et al.
Objectives: Radio-resistance hinders the effectiveness of radiotherapy for treating colorectal cancer (CRC) patients. Metadherin (MTDH) is proposed to exert a pivotal role in resistance to radiotherapy in various malignan...
Integrative Machine Learning and Experimental Validation Identify MYBL2 as a Prognostic Biomarker and Therapeutic Target in Hepatocellular Carcinoma [0.03%]
集成机器学习和实验验证鉴定MYBL2作为肝细胞癌的预后生物标志物和治疗靶点
Ya-Ling Yang,Ying-Hsien Huang,Hung-Yu Lin
Ya-Ling Yang
Background: Hepatocellular carcinoma (HCC) presents with poor treatment outcomes, creating an urgent need for novel biomarkers to improve diagnosis, prognosis, and precision medicine. While the MYB family of oncogenes is ...
MYO18A Expression is a Prognostic Factor for Progression-Free Survival in Grade 4 Adult gliomas. Preliminary Report [0.03%]
肌动蛋白结合蛋白MYO18A表达是成人IV级胶质瘤无进展生存期的预后因素：初步报告
Aleksander Strąk,Ludmiła Grzybowska-Szatkowska,Paweł Cisek et al.
Aleksander Strąk et al.
Objectives: Brain gliomas are among the tumors with the worst prognosis, and their incidence is increasing. Postoperative temozolomide-based chemoradiotherapy for grades 3 and 4 gliomas extended overall survival (OS) by a...
Multidimensional Regulatory Network of YAP1 Driving Malignant Progression in Esophageal Cancer: Molecular Mechanisms and Targeted Therapy: A Review [0.03%]
泛素特异性蛋白酶28通过调节YAP1促进食管鳞癌恶性进展的机制及靶向治疗策略研究
Jun-Hui Chen,Si-Run Du,Chang Liu et al.
Jun-Hui Chen et al.
Esophageal cancer (EC) ranks among the most lethal gastrointestinal malignancies. Due to challenges in early diagnosis, molecular heterogeneity, and therapeutic resistance, patient prognosis remains extremely poor, necessitating the develop...
Machine Learning (ML) and Molecular Dynamics-Driven Optimization of VEGFR2 Ligands against Hepatocellular Carcinoma [0.03%]
基于机器学习和分子动力学的肝癌细胞VEGFR2受体配体优化研究
Farzana Yasmeen,Abdul Manan,Wook Kim et al.
Farzana Yasmeen et al.
Objectives: Vascular endothelial growth factor receptor 2 (VEGFR2) is a critical therapeutic target in hepatocellular carcinoma (HCC) due to its role in angiogenesis and tumor progression. While several inhibitors are cur...
Therapeutic Targets for Overcoming BCR::ABL1 Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia [0.03%]
慢性粒细胞白血病BCR::ABL1酪氨酸激酶抑制剂耐药的治疗靶点
Masanobu Tsubaki,Taira Matsuo,Rie Komori
Masanobu Tsubaki
Chronic myeloid leukemia (CML) is a hematopoietic malignancy originating from hematopoietic stem cells. It is characterized by the Philadelphia chromosome, which arises from a reciprocal translocation between chromosomes 9 and 22. The break...
A Novel Partial EMT-Associated Transcriptomic Signature for Prognostic Stratification in Ovarian Cancer [0.03%]
一种新颖的与部分上皮间质转化相关的转录组标志物用于卵巢癌预后分类
Chia-Chia Chao,Cheng-Yao Lin,Po-Chun Chen et al.
Chia-Chia Chao et al.
Background: Partial epithelial-mesenchymal transition (p-EMT) is a dynamic cellular state associated with metastasis and adverse outcomes in multiple cancers, but its prognostic significance in ovarian cancer remains uncl...
SLC16A1 Activates the STAT3/SLC7A11 Pathway to Mediate Ferroptosis Resistance and Tumor Progression in Head and Neck Squamous Cell Carcinoma [0.03%]
SLC16A1通过激活STAT3/SLC7A11信号通路介导头颈部鳞状细胞癌的铁死亡抵抗和肿瘤进展
Chunhui Tian,Weipin Xie,Wen Li et al.
Chunhui Tian et al.
Background: In head and neck squamous cell carcinoma (HNSCC), solute carrier family 16 member 1 (SLC16A1) is associated with tumor advancement and reduced sensitivity to ferroptosis, yet the molecular basis of these effec...