Rethinking preclinical models for genetically engineered porcine red blood cell xenotransfusion [0.03%]
遗传工程猪红细胞异种输血的非临床模型再思考
Xiayu Lei,Hidetaka Hara,Tao Li et al.
Xiayu Lei et al.
Genetically engineered porcine red blood cells (pRBCs) are emerging as a potential supplementary source of oxygen-carrying cells for transfusion medicine. Triple-knockout (TKO) pigs lacking major carbohydrate xenoantigens, including Gal, Ne...
HHV-7 encephalitis following allogeneic hematopoietic stem cell transplantation: A case report and literature review [0.03%]
造血干细胞移植后人类第七型疱疹病毒感染性脑炎1例及文献复习
Yilei Ma,Leqing Cao,Fengrong Wang et al.
Yilei Ma et al.
Human herpesvirus 7 (HHV-7) encephalitis commonly occurs in immunocompromised individuals and has a poor prognosis. We here reported 3 cases of HHV-7 encephalitis following allogeneic hematopoietic stem cell transplantation (allo-HSCT) with...
Donor-specific immunomodulation is mediated by mechanisms beyond CD4+ regulatory T cells [0.03%]
供者特异性免疫调节作用由调节性T细胞以外的因素介导
Makiko Kumagai-Braesch,Nils Ågren,Masaaki Watanabe et al.
Makiko Kumagai-Braesch et al.
Donor-specific immunomodulatory cells (DSIMC) have successfully induced donor-specific tolerance in clinical living donor liver transplantation. These cells are generated from recipient peripheral blood mononuclear cells (PBMCs) stimulated ...
Generation of bioengineered liver grafts densely recellularized using human liver organoids [0.03%]
利用人体肝类器官密集再细胞化的生物工程化肝脏移植的生成
Keita Sonoda,Hiroshi Yagi,Shogo Nagata et al.
Keita Sonoda et al.
Bioengineered livers using decellularized extracellular matrix (ECM) scaffolds hold promise for transplantation therapies. However, conventional recellularization methods involving cell injection via blood vessels encounter challenges in re...
Muse cell transplantation attenuates neuroinflammation and preserves endothelial reparative responses after radiation-induced brain injury [0.03%]
少突胶质前体细胞移植减轻放射性脑损伤后的神经炎症并保持内皮修复反应
Xiaojie Wang,Zheng Sun,Shuang Li et al.
Xiaojie Wang et al.
Radiation-induced brain injury (RIBI) is a serious complication of cranial radiotherapy and currently lacks effective disease-modifying treatment. Persistent neuroinflammation and neurovascular dysfunction are considered central to RIBI pro...
Stem cell and extracellular vesicle therapies for wound healing: An umbrella review of predominantly diabetic and preclinical evidence [0.03%]
干细胞和细胞外囊泡治疗伤口愈合：以糖尿病为主的临床前证据的伞式审查
Nadiar M Mussin,Amin Tamadon,Mahdi Mahdipour et al.
Nadiar M Mussin et al.
Chronic and complex skin wounds, including diabetic ulcers and burns, represent a major clinical challenge with substantial morbidity and healthcare costs. Regenerative approaches have evolved from stem cell-based therapies toward stem cell...
Chronic graft-versus-host disease: Update on pathobiology, biomarkers, and evolving treatment algorithms [0.03%]
慢性移植物抗宿主病：发病机制、生物标志物及治疗策略的新进展
Yibo Wu,Xiaolin Yuan,Jinya Lin et al.
Yibo Wu et al.
Chronic graft-versus-host disease (cGVHD) remains the leading cause of late non-relapse mortality and long-term disability after allogeneic hematopoietic cell transplantation (allo-HCT), affecting 30-70% of long-term survivors. Despite its ...
Human pancreatic duct cell-derived iPSCs show enhanced differentiation into insulin-producing cells [0.03%]
人胰导管细胞来源的诱导多能干细胞向胰岛素产生细胞分化的效率更高
Sung-Bin Lim,Moon-Kyu Lee
Sung-Bin Lim
Islet transplantation is a promising treatment for diabetes, but the shortage of donor islets limits its broad application. Induced pluripotent stem cells (iPSCs) provide an alternative source for generating insulin-producing cells; however...
Host immune determinants of stromal vascular fraction graft survival: Toward a concept of SVF therapy resistance - A systematic narrative review [0.03%]
脂肪基质血管部分移植存活的宿主免疫决定因素：关于基质血管部分治疗抵抗性的概念思考——系统性叙述综述
Caroline Nonnarath,Nicolas Serratrice
Caroline Nonnarath
Stromal vascular fraction (SVF)-based therapies and autologous fat grafting have emerged as promising regenerative strategies due to their pro-angiogenic, immunomodulatory, and trophic properties. However, despite encouraging preclinical an...