New advances in the use of patient-derived organoids and mouse models for assessing heterogeneity among metastatic colorectal cancers [0.03%]
Suidong Wang,Yiran Li,Wei Wu et al.
Suidong Wang et al.
Metastatic colorectal cancers (mCRCs) exhibit substantial heterogeneity at the genetic, transcriptomic, histological, and microenvironmental levels, which contributes to therapeutic resistance and variable clinical outcomes. Patient-derived...
Qin Yang,Yinsheng Xi,Zhihong Yang et al.
Qin Yang et al.
This study investigated donor and islet isolation procedural factors influencing the islet yield during human islet isolation for transplantation. We retrospectively analyzed 133 islet isolations from deceased donors performed over 15 years...
Research landscapes and knowledge structure of cardiac xenotransplantation: A bibliometric analysis [0.03%]
Shangxuan Li,Guanzheng Cui,Ziqiang Dai et al.
Shangxuan Li et al.
Cardiac xenotransplantation is advancing rapidly from basic research to early clinical use, but its research landscape has not been comprehensively mapped. We conducted a bibliometric and science-mapping analysis of English-language article...
Tobias Niederegger,Thomas Schaschinger,Gabriel Hundeshagen et al.
Tobias Niederegger et al.
Vascularized composite allotransplantation (VCA) enables functional and aesthetic reconstruction after complex tissue loss but remains limited by donor scarcity and immunosuppression. Xenotransplantation, using tissues from other species, o...
Preclinical safety assessment and immunological evaluation of xenogeneic mammary cells of porcine origin, utilized as an intralesional immunotherapeutic agent [0.03%]
异种细胞作为免疫治疗剂的临床前安全性和免疫学评价研究——以猪乳腺干细胞为例
Liang-Chih Liu,Chih-Rong Shyr,Ting-Yu Lin et al.
Liang-Chih Liu et al.
Xenogeneic cells isolated from safe animal tissues and expanded ex vivo hold potential as immunotherapeutic agents capable of stimulating the body's immune system to treat cancers. This study aimed to evaluate the in vivo safety and immunol...
Molecular mechanisms responsible for mesenchymal stem cell-dependent improvement of islet cell transplantation [0.03%]
间充质干细胞依赖性改善胰岛细胞移植的分子机制研究
Vladislav Volarevic,Carl Randall Harrell,Crissy Fellabaum et al.
Vladislav Volarevic et al.
Islet cell transplantation holds great promise for restoring glycemic control in patients with type 1 diabetes. However, its long-term efficacy remains limited due to poor islet survival, immune rejection, and insufficient vascularization. ...
Gelatin sponge loaded with hypoxic human umbilical cord mesenchymal stem cell exosomes promotes healing of enterocutaneous fistula [0.03%]
载有低氧人脐带间充质干细胞外泌体的明胶海绵促进肠皮肤瘘愈合
Yankui Liu,Wenwen Yu,Guang Wang et al.
Yankui Liu et al.
Enterocutaneous fistula (ECF) traditionally relies on surgical treatment and lacks effective therapies to promote tissue regeneration. This study constructed a composite system based on hypoxia-preconditioned human umbilical cord mesenchyma...
Xiaojuan Yang,Miaohui Wang,Xuhang Fan et al.
Xiaojuan Yang et al.
Recent years have witnessed rapid progress in mitochondrial transplantation (MT) as a novel strategy for restoring mitochondrial function in diverse pathological conditions, including somatic mitochondrial transfer and reproductive mitochon...
Long-term outcomes of autologous cell transplantation for patients with non-TAO autoimmune disease-related critical limb ischemia [0.03%]
自体细胞移植治疗非TAO自身免疫性疾病相关严重肢体缺血患者的长期疗效分析
Hao Liu,Lingwei Zou,Yuan Fang et al.
Hao Liu et al.
Autoimmune disease-related critical limb ischemia (AD-CLI) represents a significant portion of no-option critical limb ischemia (NO-CLI). Despite the demonstrated safety and efficacy of cell transplantation for NO-CLI, most studies focused ...
A novel GMP-manufactured medicinal product candidate composed of NK and γδ T cells as adjunct immunotherapy for hematopoietic stem cell transplantation [0.03%]
一种新型符合GMP标准的药物候选产品，包含NK和γδT细胞，作为造血干细胞移植的免疫治疗辅助疗法
Fabio Morandi,Martina Della Lastra,Gino Tripodi et al.
Fabio Morandi et al.
γδ T lymphocytes and NK cells are effective to kill tumors or viral-infected cells avoiding graft versus host disease (GvHD), thus they have attracted high interest as potential tool for adoptive cell therapy. We generated an advanced the...