[This corrects the article on p. 301 in vol. 6, PMID: 9368101.].
Published Erratum
Gene expression. 2018 Sep 24;7(2):131. DOI: 2018
Inflammation and Cell Death During Cholestasis: The Evolving Role of Bile Acids [0.03%]
胆汁淤积期间的炎症和细胞死亡：胆汁酸的作用逐渐演变
Benjamin L Woolbright,Hartmut Jaeschke
Benjamin L Woolbright
Cholestasis results in blockage of bile flow whether the point of obstruction occurs extrahepatically or intrahepatically. Bile acids are a primary constituent of bile, and thus one of the primary outcomes is acute retention of bile acids i...
The Hippo Pathway and YAP Signaling: Emerging Concepts in Regulation, Signaling, and Experimental Targeting Strategies With Implications for Hepatobiliary Malignancies [0.03%]
Hippo信号通路与YAP信号转导：调控、信号转导及实验靶向策略的新概念及其对肝胆恶性肿瘤的意义
Nathan Werneburg,Gregory J Gores,Rory L Smoot
Nathan Werneburg
The Hippo pathway and its effector protein YAP (a transcriptional coactivator) have been identified as important in the biology of both hepatocellular carcinoma and cholangiocarcinoma. First identified as a tumor suppressor pathway in Droso...
Jia-Zhen Zhang,Jing-Jing Cai,Yao Yu et al.
Jia-Zhen Zhang et al.
Nonalcoholic fatty liver disease (NAFLD) is a common liver disease and a major cause of related complications such as cirrhosis and hepatocellular carcinoma (HCC). NAFLD progresses through the stages of simple steatosis, nonalcoholic steato...
Ming-Ming Chen,Jing-Jing Cai,Yao Yu et al.
Ming-Ming Chen et al.
Nonalcoholic steatohepatitis (NASH) is the second leading cause of liver transplantation in the US with a high risk of liver-related morbidities and mortality. Given the global burden of NASH, development of appropriate therapeutic strategi...
Sterol 12α-Hydroxylase Aggravates Dyslipidemia by Activating the Ceramide/mTORC1/SREBP-1C Pathway via FGF21 and FGF15 [0.03%]
胆固醇12α羟化酶通过FGF21和FGF15激活鞘氨醇/MTORC1/SREBP-1C通路加重脂质异常累积导致血脂紊乱
Preeti Pathak,John Y L Chiang
Preeti Pathak
Sterol 12α-hydroxylase (CYP8B1) is required for the synthesis of cholic acid in the classic bile acid synthesis pathway and plays a role in dyslipidemia and insulin resistance. However, the mechanism of the involvement of Cyp8b1 in dyslipi...
Emerging Players in Autophagy Deficiency-Induced Liver Injury and Tumorigenesis [0.03%]
自噬缺陷性肝损伤和肿瘤发生的新兴调控因子
Hua Yang,Hong-Min Ni,Wen-Xing Ding
Hua Yang
Studies using genetic mouse models that have defective autophagy have led to the conclusion that macroautophagy/autophagy serves as a tumor suppressor. One of such models is the liver-specific Atg5 or Atg7 knockout mice, and these knockout ...
Tirthadipa Pradhan-Sundd,Satdarshan Pal Monga
Tirthadipa Pradhan-Sundd
The term blood-bile barrier (BBlB) refers to the physical structure within a hepatic lobule that compartmentalizes and hence segregates sinusoidal blood from canalicular bile. Thus, this barrier provides physiological protection in the live...
Elimination of Wnt Secretion From Stellate Cells Is Dispensable for Zonation and Development of Liver Fibrosis Following Hepatobiliary Injury [0.03%]
去极化细胞分泌Wnt蛋白对于肝损伤后肝板区隔和肝纤维化的发展并非必需
Rong Zhang,Alexander T Kikuchi,Toshimasa Nakao et al.
Rong Zhang et al.
Alterations in the Wnt signaling pathway including those impacting hepatic stellate cells (HSCs) have been implicated in liver fibrosis. In the current study, we first examined the expression of Wnt genes in human HSC (HHSCs) after treatmen...
PRMT1-Dependent Macrophage IL-6 Production Is Required for Alcohol-Induced HCC Progression [0.03%]
酒精诱导的肝细胞癌发展的过程中依赖PRMT1调控的巨噬细胞产生IL-6是必需的
Jie Zhao,Maura O&#x;Neil,Anusha Vittal et al.
Jie Zhao et al.
Alcohol is a well-established risk factor for hepatocellular carcinoma, but the mechanisms are not well understood. Several studies suggested that alcohol promotes tumor growth by altering immune cell phenotypes in the liver. Arginine methy...