Current and Emerging Molecular Markers of Liver Diseases: A Pathogenic Perspective [0.03%]
肝病的分子标志物：发病机制角度的现状与前景
Yuanxin Liang,Grace L Guo,Lanjing Zhang
Yuanxin Liang
In the past decade, with the rapid development of molecular medicine and the application of more sophisticated methods for disease diagnosis and treatment, a number of molecular markers have become available for liver diseases. Pathogenesis...
Role of Noncoding RNAs in Acetaminophen-Induced Liver Injury [0.03%]
非编码RNA在 acetaminophen 诱导的肝损伤中的作用
Vivek Chowdhary,Pipasha Biswas,Kalpana Ghoshal
Vivek Chowdhary
Genomic and transcriptomic analyses have well established that the major fraction of the mammalian genome is transcribed into different classes of RNAs ranging in size from a few nucleotides to hundreds of thousands of nucleotides, which do...
Hepatocyte-Specific Hepatocyte Nuclear Factor 4 Alpha (HNF4) Deletion Decreases Resting Energy Expenditure by Disrupting Lipid and Carbohydrate Homeostasis [0.03%]
肝细胞特异性肝核因子4α缺失通过干扰脂质和碳水化合物稳态减少基础能量消耗
Ian Huck,E Matthew Morris,John Thyfault et al.
Ian Huck et al.
Hepatocyte nuclear factor 4 alpha (HNF4) is required for hepatocyte differentiation and regulates expression of genes involved in lipid and carbohydrate metabolism including those that control VLDL secretion and gluconeogenesis. Whereas pre...
Nicole Martucci,George K Michalopoulos,Wendy M Mars
Nicole Martucci
Integrin linked kinase (ILK) is a vital signaling protein ubiquitously expressed throughout the body. It binds to intracellular integrins to help promote signaling related to cell adhesion, apoptosis, proliferation, migration, and a plethor...
Wnt/-Catenin Signaling and Liver Regeneration: Circuit, Biology, and Opportunities [0.03%]
Wnt/-Catenin信号通路与肝再生：回路、生物学和机遇
Shikai Hu,Satdarshan P Monga
Shikai Hu
The liver is uniquely bestowed with an ability to regenerate following a surgical or toxicant insult. One of the most researched models to demonstrate the regenerative potential of this organ is the partial hepatectomy model, where two thir...
Ferroptosis and Acetaminophen Hepatotoxicity: Are We Going Down Another Rabbit Hole? [0.03%]
铁死亡与对乙酰氨基酚肝毒性：我们在探寻新的真相吗？
Hartmut Jaeschke,Olamide B Adelusi,Anup Ramachandran
Hartmut Jaeschke
Acetaminophen (APAP) hepatotoxicity is the most frequent cause of acute liver failure in the US. The mechanisms of APAP-induced liver injury have been under extensive investigations for decades, and many key events of this necrotic cell dea...
Characterization of the Gene Expression Patterns in the Murine Liver Following Intramuscular Administration of Baculovirus [0.03%]
家兔肌肉注射杆状病毒后小鼠肝基因表达谱的研究
Mitsuhiro Iyori,Ryohei Ogawa,Talha Bin Emran et al.
Mitsuhiro Iyori et al.
Intramuscular administration of wild-type baculovirus is able to both protect against Plasmodium sporozoite challenge and eliminate liver-stage parasites via a Toll-like receptor 9-independent pathway. To investigate its effector mechanism(...
The Conundrum of the Pericentral Hepatic Niche: WNT/-Catenin Signaling, Metabolic Zonation, and Many Open Questions [0.03%]
围绕着肝中央周边区域的困惑：WNT/-连环蛋白信号、代谢分区以及许多未解问题
Jan S Tchorz
Jan S Tchorz
WNT/-catenin signaling promotes stemness, proliferation, and cell fate decisions in various tissue stem cell compartments, which maintain organs with a high turnover of cells (e.g., skin, stomach, and gut). Thus, the -catenin target genes A...
The Dynamic Interplay Between Mast Cells, Aging/Cellular Senescence, and Liver Disease [0.03%]
肥大细胞、衰老/细胞衰老和肝病之间的动态相互作用
Debjyoti Kundu,Lindsey Kennedy,Vik Meadows et al.
Debjyoti Kundu et al.
Mast cells are key players in acute immune responses that are evidenced by degranulation leading to a heightened allergic response. Activation of mast cells can trigger a number of different pathways contributing to metabolic conditions and...
Epidemiological Realities of Alcoholic Liver Disease: Global Burden, Research Trends, and Therapeutic Promise [0.03%]
酒精性肝病的流行病学现状：全球疾病负担、研究趋势和治疗前景
Jia Xiao,Fei Wang,Nai-Kei Wong et al.
Jia Xiao et al.
Globally, alcohol consumption contributes to more than 3 million deaths each year. While much of its ramifications is preventable, a coherent public health discourse on how to limit alcohol-related harm has been overdue. By synthesizing inf...