Brenton R Ware,Grace E Brown,Valerie Y Soldatow et al.
Brenton R Ware et al.
Testing drugs in isogenic rodent strains to satisfy regulatory requirements is insufficient for derisking organ toxicity in genetically diverse human populations; in contrast, advances in mouse genetics can help mitigate these limitations. ...
Published Erratum
Gene expression. 2020 Jun 12;20(1):75-76. DOI:10.3727/105221620X15886997679754 2020
Satdarshan P Monga
Satdarshan P Monga
The incidence of hepatocellular cancer (HCC) is gradually rising. HCC occurs as a sequela to various chronic liver diseases and ensuing cirrhosis. There have been many therapies approved for unresectable HCC in the last 5 years, including i...
Acetaminophen Test Battery (ATB): A Comprehensive Method to Study Acetaminophen-Induced Acute Liver Injury [0.03%]
acetaminophen检测板（ATB）:一种研究对乙酰氨基酚致急性肝损伤的全面方法
Bharat Bhushan,Udayan Apte
Bharat Bhushan
Acetaminophen (APAP) overdose is the major cause of acute liver failure (ALF) in the Western world. Extensive research is ongoing to identify the mechanisms of APAP-induced ALF. APAP-induced acute liver injury is also one of the most common...
Downregulation of p16 Decreases Biliary Damage and Liver Fibrosis in the Mdr2/ Mouse Model of Primary Sclerosing Cholangitis [0.03%]
下调p16减少Mdr2缺陷小鼠原发性硬化性胆管炎模型的胆道损害和肝纤维化
Konstantina Kyritsi,Heather Francis,Tianhao Zhou et al.
Konstantina Kyritsi et al.
Biliary senescence and hepatic fibrosis are hallmarks of cholangiopathies including primary sclerosing cholangitis (PSC). Senescent cholangiocytes display senescence-associated secretory phenotypes [SASPs, e.g., transforming growth factor-1...
Immune Checkpoint Inhibitors in Hepatocellular Cancer: Current Understanding on Mechanisms of Resistance and Biomarkers of Response to Treatment [0.03%]
免疫检查点抑制剂在肝细胞癌中的耐药机制及治疗反应生物标志物的当前研究进展
Amblessed E Onuma,Hongji Zhang,Hai Huang et al.
Amblessed E Onuma et al.
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy worldwide and a leading cause of death worldwide. Its incidence continues to increase in the US due to hepatitis C infection and nonalcoholic steatohepatitis. Liver ...
Loss of ARF/INK4A Promotes Liver Progenitor Cell Transformation Toward Tumorigenicity Supporting Their Role in Hepatocarcinogenesis [0.03%]
ARF/INK4A的丢失促进肝干细胞向肿瘤发生性的转化支持他们在肝癌发生中的作用
Robyn P Strauss,Katherine M Audsley,Adam M Passman et al.
Robyn P Strauss et al.
Liver progenitor cells (LPCs) contribute to liver regeneration during chronic damage and are implicated as cells of origin for liver cancers including hepatocellular carcinoma (HCC). The CDKN2A locus, which encodes the tumor suppressors alt...
Microscale Collagen and Fibroblast Interactions Enhance Primary Human Hepatocyte Functions in Three-Dimensional Models [0.03%]
微尺度胶原蛋白和成纤维细胞的相互作用可增强三维模型中的初级人肝细胞功能
David A Kukla,Alexandra L Crampton,David K Wood et al.
David A Kukla et al.
Human liver models that are three-dimensional (3D) in architecture are indispensable for compound metabolism/toxicity screening, to model liver diseases for drug discovery, and for cell-based therapies; however, further development of such ...
Reduction in SNAP-23 Alters Microfilament Organization in Myofibrobastic Hepatic Stellate Cells [0.03%]
SNAP-23的减少改变了肌成纤维母细胞样肝星状细胞中的微丝组织状态
Haleigh B Eubanks,Elise G Lavoie,Jessica Goree et al.
Haleigh B Eubanks et al.
Hepatic stellate cells (HSC) are critical effector cells of liver fibrosis. In the injured liver, HSC differentiate into a myofibrobastic phenotype. A critical feature distinguishing myofibroblastic from quiescent HSC is cytoskeletal reorga...
If It Looks Like a Duct and Acts Like a Duct: On the Role of Reprogrammed Hepatocytes in Cholangiopathies [0.03%]
如果它看起来像一根导管且表现得像一根导管：论重新编程的肝细胞在胆道疾病中的作用
Kari Nejak-Bowen
Kari Nejak-Bowen
Cholangiopathies are chronic, progressive diseases of the biliary tree, and can be either acquired or genetic. The primary target is the cholangiocyte (CC), the cell type lining the bile duct that is responsible for bile modification and tr...
Long-Term Engineered Cultures of Primary Mouse Hepatocytes for Strain and Species Comparison Studies During Drug Development [0.03%]
小鼠原代肝细胞长期培养系统在药物研发中的品系和物种对比研究中的应用
Brenton R Ware,Grace E Brown,Valerie Y Soldatow et al.
Brenton R Ware et al.
Testing drugs in isogenic rodent strains to satisfy regulatory requirements is insufficient for derisking organ toxicity in genetically diverse human populations; in contrast, advances in mouse genetics can help mitigate these limitations. ...