Synthesis and Characterization of Radio-Halogenated Talazoparib Analogues for Imaging and Radioligand Therapy [0.03%]
放射性卤化talazoparib类似物的合成与表征用于成像和放射配体治疗
Riccardo Muzzioli,Federica Pisaneschi,Seth T Gammon et al.
Riccardo Muzzioli et al.
Talazoparib (TZ) is a potent poly(ADP-ribose) polymerase 1/2 (PARP1/2) inhibitor that uniquely traps PARP complexes at sites of single-strand DNA damage thereby offering opportunities for targeted radioligand therapy. Radiolabeled halogenat...
Defining Glycan Recognition by DC-SIGN Using Native Mass Spectrometry [0.03%]
利用原位质谱技术定义DC-SIGN的糖链识别机制
Duong T Bui,Elena N Kitova,Lara K Mahal et al.
Duong T Bui et al.
C-type lectins (CTLs), many of which bind carbohydrates (glycans) in a Ca2+-dependent manner, are an important family of glycan-binding proteins that play essential roles in immune recognition and regulation. Among them, dendritic cell-spec...
Direct Small Molecule Modulation of LILRB4 (ILT3) Restores Antitumor Immunity In Vivo and in Patient-Derived Cells [0.03%]
直接的小分子调节LILRB4（ILT3）恢复体内和患者来源细胞的抗肿瘤免疫反应
Somaya A Abdel-Rahman,Zamara Mariam,Giuseppe Deganutti et al.
Somaya A Abdel-Rahman et al.
Small molecule targeting of suppressive myeloid immune checkpoints remains a major challenge in cancer immunotherapy, particularly for nonenzymatic receptors lacking conventional druggable active sites. Leukocyte immunoglobulin-like recepto...
Molecular Determinants of Ribosome Binding for the Antimicrobial Peptide Pdi1 [0.03%]
抗菌肽PDI1与核糖体结合的分子决定因素
Trevor T Dean,Alyah Ziyad,Dorota Klepacki et al.
Trevor T Dean et al.
Type II proline-rich antimicrobial peptides have emerged as promising therapeutic candidates due to their ability to inhibit a previously undrugged stage of bacterial protein synthesis: translation termination. The recent characterization o...
Alkyne Tags for Multiplexed, Optical Photothermal Infrared Imaging of Cellular Metabolites [0.03%]
用于细胞代谢物多重光学光热红外成像的炔烃标签
Halley M Lin-Jones,Tuyet Hoang,Yong Li et al.
Halley M Lin-Jones et al.
Optical photothermal infrared (OPTIR) microscopy has emerged as a powerful strategy for vibrational imaging within complex cellular environments. This platform offers subcellular resolution without the diffraction limits of traditional IR. ...
TEO-GalNAc: MS Tag-Free Chemoenzymatic Enrichment and Relative Assessment of Tn/T Antigen Sialylation Occupancy via Ketone-Oxime Chemistry [0.03%]
基于酮-肟化学的TEO-GalNAc：Tn / T抗原岩藻糖基化 occupancy 的化学酶法浓缩和相对评估及MS 标签-Free 方法
Li Liu,Yinping Tian,Zhuo Zhang et al.
Li Liu et al.
Tn/T antigens and their sialylated forms (STn/ST) are tumor-associated truncated O-glycans whose selective enrichment and MS analysis remain challenging due to limited enrichment efficiency and the MS-incompatible bulky tags in conventional...
Jennifer Sescil,Isabel Solowiej,Guanwei Zhou et al.
Jennifer Sescil et al.
Protease cleavage is a crucial process, associated with cellular signaling and viral infection. Here, we present a novel sensing motif based on a proximity-dependent biotin ligase, TurboID. The sensor, Biotin Annotating Genetically Encoded ...
Chemically Responsive Protein Switches for the Precise Control of Biological Activities [0.03%]
用于精确控制生物活性的化学响应型蛋白质开关
Jaime Franco Pinto,Naama Drahy,Séverine Divoux et al.
Jaime Franco Pinto et al.
Controlling the proximity or interaction of proteins with small molecules enables researchers to chemically regulate cellular functions. Here, we leveraged CATCHFIRE (chemically assisted tethering of chimera by fluorogenic induced recogniti...
Chemical Interactions between the Common Soil Bacteria Pseudomonas chlororaphis and Bacillus subtilis [0.03%]
荧光假单胞菌与枯草芽孢杆菌之间的化学相互作用
Zohar Tik,Shaked Uzi-Gavrilov,Bat-El Hagbi-Lazar et al.
Zohar Tik et al.
Chemical signaling between soil inhabitants is of tremendous importance to the health of many ecosystems, and at the same time detailed molecular knowledge underlying these conversations is surprisingly scarce. One of the major bacterial ge...
Pre-miR-21 Conformational Equilibrium Modulates the Efficacy of the Maturation Inhibitor L50 [0.03%]
miR-21的构象平衡调节成熟抑制剂L50的作用效果
Yuhei Nishimura,Yuji Tokunaga,Yutaka Kofuku et al.
Yuhei Nishimura et al.
The cyclic peptide L50 is a promising anticancer candidate that inhibits miR-21 maturation by targeting the Dicer cleavage site of pre-miR-21. A recent study revealed that pre-miR-21 exists in equilibrium between an Ade-29-deprotonated Bulg...