Correction to "Understanding the Glycosylation Pathways Involved in the Biosynthesis of the Sulfated Glycan Ligands for Siglecs" [0.03%]
“揭秘参与寡糖配体生物合成的糖基化途径”一文的更正通知
Jaesoo Jung,Edward N Schmidt,Hua-Chien Chang et al.
Jaesoo Jung et al.
Published Erratum
ACS chemical biology. 2025 Oct 13. DOI:10.1021/acschembio.5c00772 2025
Development of Second-Generation Acyl Silane Photoaffinity Probes for Cellular Chemoproteomic Profiling [0.03%]
用于细胞化学蛋白质组学分析的第二代酰基硅烷光亲和探针的发展
Annika C S Page,Lauren M Orr,Margot L Meyers et al.
Annika C S Page et al.
Deconvolution of the protein targets of hit compounds from phenotypic screens, often conducted in live cells, is critical for understanding mechanism of action and identifying potentially hazardous off-target interactions. While photoaffini...
SHAPE-Based Chemical Probes for Studying preQ1-RNA Interactions in Living Bacteria [0.03%]
基于SHAPE原理设计化学探针研究活菌中preQ1-RNA相互作用
José A Reyes Franceschi,Emilio L Cárdenas,Brandon J C Klein et al.
José A Reyes Franceschi et al.
Interrogating RNA-small molecule interactions inside cells is critical for advancing RNA-targeted drug discovery. In particular, chemical probing technologies that both identify small molecule-bound RNAs and define their binding sites in th...
Virus Propagation Linked to Exceedingly Rare Gene-Expression Errors: A Single-Molecule Microscopy Demonstration [0.03%]
利用单分子显微镜技术证明病毒传播与极罕见的基因表达错误有关
Raquel Luzón-Hidalgo,Gianluca D&#x;Agostino,Valeria A Risso et al.
Raquel Luzón-Hidalgo et al.
Many viruses use programmed frameshifting and stop-codon misreading to synthesize functional proteins at high levels. The underlying mechanisms involve complex RNA sequence/structure motifs and likely reflect optimization driven by natural ...
Taxodione Inhibits Glioblastoma Proliferation and Potentiates the Cytotoxicity of Paclitaxel [0.03%]
_taxodione抑制胶质母细胞瘤增殖并增强紫杉醇的细胞毒性
Kyle J Parella,Megan M Solans,Cynthia Vied et al.
Kyle J Parella et al.
Glioblastoma rapidly acquires resistance to conventional genotoxic therapy. This behavior is closely associated with the enhancement of stem-cell-like character during disease progression. Farnesyl diphosphate synthase (FDPS) plays an impor...
Biosynthesis of Antifungal Fusacandins Reveals Distinctive Fungal C- and Iterative O-type Glycosyltransferases [0.03%]
抗真菌融合抗生素菲萨康丁的生物合成揭示了独特的C-和迭代O-型糖基转移酶功能
Xin Wang,Cheng-Jun Cao,Yi Zou
Xin Wang
Fusacandin A (1) is a glycolipid natural product that targets β-1,3-glucan synthase and exhibits significant antifungal activity. Its most impressive structural feature is a C-arylglycosyl hydroxybenzyl moiety with a varying degree of O-gl...
Mechanism and Utility of the ATP-Grasp Enzyme BesA for the Synthesis of Non-natural Alkyne-Containing Dipeptides Applicable for Click Chemistry [0.03%]
用于合成适用于点击化学的非天然炔基肽的ATP- grasp酶BesA的机制和用途
Hono Otsuka,Takashi Fujishiro
Hono Otsuka
Terminal alkyne-containing biomolecules are key compounds utilized in bioorthogonal chemistry via azide-alkyne cycloaddition click chemistry. Various synthetic strategies for the introduction of the terminal alkyne to biomolecules have been...
A Cell-Potent Bisubstrate Inhibitor to Probe NatD Acetyltransferase Activity [0.03%]
一种细胞全能双底物抑制剂用于探针NatD乙酰转移酶活性
Yi-Hsun Ho,Emma K Seipp,Thitiwat Larndate et al.
Yi-Hsun Ho et al.
N-terminal acetyltransferase D (NatD) is a highly selective enzyme that acetylates the α-N-terminal amine of histones H4 and H2A, which share the SGRGK motif. Elevated NatD expression has been observed in lung, colorectal, breast, and bone...
Iodo-Labeling of Peptides for Quantitative MALDI MS Analysis─Screening for Bacteria-Binding Peptides from a Glycine-Zipper Library [0.03%]
用于定量MALDI质谱分析的肽的放射性碘标记──从甘氨酸拉链型文库中筛选与细菌结合的肽
Liao Hu,C Logan Mackay,David J Clarke et al.
Liao Hu et al.
Matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) is widely valued for its speed and sensitivity in biomolecular analysis, yet the inherently nonquantitative nature hampers its use in many applications including high-...
Amide Nitrogen Pyramidalization via N-H/N Interactions that Stabilize the δ/α Conformations in Turns, Loops, and 310- and α-Helices [0.03%]
酰胺氮通过N-H/N相互作用发生(py)化稳定转角、环肽及3₁₀和α螺旋中的δ/α构象
Noah J Daniecki,Glenn P A Yap,Neal J Zondlo
Noah J Daniecki
N-H/N interactions, between an amide N-H on one residue (i + 1) and the amide N lone pair on the prior (i) residue, have been observed in key structures in proteins, including turns, loops, and α-helices. However, there remains an incomple...