LYECs: lysosome-enhancing compounds as potential therapeutic approaches for Alzheimer disease [0.03%]
用于治疗阿尔茨海默病的溶酶体增强型化合物LYECs的研究
Limin Yin,Yu Zhou,Hong Liu et al.
Limin Yin et al.
More than 55 million people are suffering from Alzheimer's disease (AD), but there is still no effective treatment for it. Therefore, novel therapeutic approaches and regulatory mechanisms of protein quality control need to be further evalu...
RHOA, a small G-protein, signals to mitophagy through regulation of PINK1 protein stability and protects cardiomyocytes against ischemia [0.03%]
RHOA通过调节PINK1蛋白稳定性向线粒体自噬信号转导并保护心肌细胞免受缺血损伤
Michelle Tu,Shigeki Miyamoto
Michelle Tu
RHOA (ras homolog family member A) is a small G-protein that regulates a range of cellular processes including cell growth and survival. RHOA is a proximal downstream effector of G protein-coupled receptors coupling to GNA12/Gα12-GNA13/Gα...
Cardio-, hepato- and pneumoprotective effects of autophagy checkpoint inhibition by targeting DBI/ACBP [0.03%]
靶向DBI / ACBP抑制自噬检查点的心脏保护，肝脏保护和肺保护作用
Omar Motiño,Flavia Lambertucci,Gerasimos Anagnostopoulos et al.
Omar Motiño et al.
DBI/ACBP (diazepam binding inhibitor, also known as acyl coenzyme A binding protein), acts as a paracrine inhibitor of macroautophagy/autophagy. We characterized a monoclonal antibody neutralizing mouse DBI/ACBP (a-DBI) for its cytoprotecti...
A noncanonical autophagy function of ATG9A for Golgi integrity and dynamics [0.03%]
ATG9A的非经典自噬功能影响高尔基复合体的完整性和动态变化
Yuanyuan Meng,Qian Luo,Quan Chen et al.
Yuanyuan Meng et al.
In mammalian cells, the Golgi apparatus serves as the central hub for membrane trafficking. Notably, the membrane trafficking and Golgi integrity are tightly regulated by reversible post-translational modifications, such as glycosylation, p...
The Cys-N-degron pathway modulates pexophagy through the N-terminal oxidation and arginylation of ACAD10 [0.03%]
含胱氨酸的N末端衰减子途径通过ACAD10的N端氧化和精氨基化调节自噬体形成
Sang Mi Shim,Ha Rim Choi,Soon Chul Kwon et al.
Sang Mi Shim et al.
In the N-degron pathway, N-recognins recognize cognate substrates for degradation via the ubiquitin (Ub)-proteasome system (UPS) or the autophagy-lysosome system (hereafter autophagy). We have recently shown that the autophagy receptor SQST...
Autophagy proteins are essential for aminoglycoside-induced hearing loss [0.03%]
自噬相关蛋白对氨基糖苷类抗生素诱导的耳聋至关重要
Jinan Li,Chang Liu,Ulrich Müller et al.
Jinan Li et al.
Aminoglycosides (AGs) are widely used to treat severe infections. However, systemically administered AGs preferentially kill cochlear hair cells, resulting in irreversible hearing loss. Recently, we found that AGs bind to RIPOR2 and trigger...
Mitochondria-ER cooperation: NLRX1 detects mitochondrial protein import stress and promotes mitophagy through the ER protein RRBP1 [0.03%]
线粒体-内质网协作：NLRX1感应线粒体蛋白输入压力并通过内质网蛋白RRBP1促进自噬 mitochondrion
Samuel A Killackey,Yuntian Bi,Dana J Philpott et al.
Samuel A Killackey et al.
Mitochondria rely on efficient protein import across their membranes for optimal function. We have shown that numerous mitochondrial stressors all converge on a common pathway disrupting this import efficiency. We identified a novel pathway...
FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation [0.03%]
FOXP3+巨噬细胞抑制急性缺血性卒中诱导的神经炎症
Wei Cai,Mengyan Hu,Chunyi Li et al.
Wei Cai et al.
Proper termination of cell-death-induced neural inflammation is the premise of tissue repair in acute ischemic stroke (AIS). Macrophages scavenge cell corpses/debris and produce inflammatory mediators that orchestrate immune responses. Here...
Brassinosteroids modulate autophagy through phosphorylation of RAPTOR1B by the GSK3-like kinase BIN2 in Arabidopsis [0.03%]
brassinosteroid通过GSK3样的激酶BIN2磷酸化RAPTOR1B调节拟南芥自噬作用
Ching-Yi Liao,Yunting Pu,Trevor M Nolan et al.
Ching-Yi Liao et al.
Macroautophagy/autophagy is a conserved recycling process that maintains cellular homeostasis during environmental stress. Autophagy is negatively regulated by TOR (target of rapamycin), a nutrient-regulated protein kinase that in plants is...
Mala V Rao,Sandipkumar Darji,Philip H Stavrides et al.
Mala V Rao et al.
How macroautophagy/autophagy influences neurofilament (NF) proteins in neurons, a frequent target in neurodegenerative diseases and injury, is not known. NFs in axons have exceptionally long half-lives in vivo enabling formation of large st...