Rui Liu,Tamar Avin-Wittenberg,Qingqiu Gong
Rui Liu
Chloroplasts are photosynthetic, protein-rich organelles unique to green plants and algae. In more complex plants, each mesophyll cell may contain up to 100 chloroplasts, each 5 - 10 µm in length, and 50% of plant proteins are stored in ch...
A secretory protein from " candidatus Liberibacter asiaticus" targets SNARE protein CsVTI13 to suppress autophagosome-vacuole fusion and promote bacterial infection [0.03%]
“Candidatus Liberibacter asiaticus”分泌蛋白通过靶向SNARE蛋白CsVTI13抑制自噬溶酶体融合并促进细菌感染
Xuejin Cui,Meixia Du,Xiyin Zheng et al.
Xuejin Cui et al.
Macroautophagy/autophagy functions in plant host immunity responses to pathogen infection. The molecular mechanisms and functions used by the citrus Huanglongbing (HLB)-associated intracellular bacterium "Candidatus Liberibacter asiaticus" ...
Hijacking a cellular highway: non-lipidated LC3 proteins and PCNT (pericentrin) drive influenza a virus uncoating [0.03%]
劫持细胞内运输途径：非脂化LC3蛋白和PCNT（中心体周围蛋白）驱动A型流感病毒解聚
Yingying Cong,Fulvio Reggiori
Yingying Cong
MAP1LC3/LC3 (microtubule associated protein 1 light chain 3) proteins have long been thought to carry out their cellular and organismal functions, including macroautophagy/autophagy, exclusively in their lipidated form, also referred to as ...
PPP2/PP2A-mediated dephosphorylation of LC3B links PINK1-PRKN/Parkin-mediated mitophagy to SCA12 pathogenesis [0.03%]
PINK1-PRKN/Parkin介导的线粒体自噬与SCA12发病机制中PPP2/PP2A介导的LC3B去磷酸化的作用链接研究
Ningning Li,Hongyu Hou,Dan Su et al.
Ningning Li et al.
Atg8-family proteins are autophagosome-associated proteins and play important roles in macroautophagy/autophagy, a conserved process for degrading defective or excessive cellular components. Post-translational modifications of mammalian Atg...
Atg2/TRAPPIII-Ypt1 axis: deciphering the phagophore-ERES connection [0.03%]
自噬起始中的Atg2/TRAPPIII-Ypt1轴：揭秘吞噬体与内质网出芽位点的联系
Rubén Gómez-Sánchez,J Christopher Fromme,Christian Ungermann et al.
Rubén Gómez-Sánchez et al.
De novo generation of membrane contact sites (MCSs) between the nascent phagophore and the endoplasmic reticulum (ER), particularly the ER exit sites (ERES), are crucial for autophagy as they provide the lipids necessary for the phagophore ...
Jayanta Debnath,Gourish Mondal
Jayanta Debnath
In breast cancer, macroautophagy/autophagy suppresses key steps of the metastatic cascade, including colonization and outgrowth at distant sites. However, the molecular mechanisms behind this suppression have remained unclear. Our recent st...
Targeted genome editing of ZKSCAN3 mitigates the neurotoxicity caused by mutant HTT (huntingtin) in a Huntington disease animal model and three-dimensional cell culture of Huntington disease [0.03%]
靶向ZKSCAN3基因组编辑可缓解亨廷顿舞蹈病动物模型和三维细胞培养中的突变HTT（亨廷顿蛋白）神经毒性作用
Hyun Jung Park,JiYeon Kim,Jiwoo Choi et al.
Hyun Jung Park et al.
Huntington disease (HD) is a neurodegenerative disease caused by the expression of a mutant form of HTT (huntingtin; mHTT), caused by an abnormal expansion of polyglutamine in HTT. In HD, macroautophagy/autophagy dysfunction can cause mHTT ...
Aging-rewired metabolic cues promote autophagy and senescence via DRAM1 [0.03%]
DRAM1代谢调节自噬和衰老促进机体应对衰老失调
Jinghong Yang,Haobin Sun,Keqing Xu et al.
Jinghong Yang et al.
Being a major contributor to cell senescence and aging, DNA damage activates macroautophagy/autophagy, but how this process is affected by aging-rewired metabolism in normal biological systems remains to be explored. Here in cultured human ...
Pneumolysin-dependent and independent non-canonical autophagy processes mediate host defense against pneumococcal infection [0.03%]
肺炎链球菌感染的宿主防御依赖和独立于肺炎毒素的非经典自噬途径
Bartosz J Michno,Niedharsan Pooranachandran,Tonisha C Smith et al.
Bartosz J Michno et al.
Streptococcus pneumoniae is an opportunistic pathogen responsible for life-threatening diseases including pneumonia and meningitis. The host defense against pneumococci relies heavily on macrophages, which can effectively internalize and de...
Non-canonical role of ATG4B in PRMT1-mediated DNA repair and leukemia progression [0.03%]
ATG4B在PRMT1介导的DNA修复及白血病发生中的非经典作用
Zhenkun Wang,Yuting Fu,Shuyi Lin et al.
Zhenkun Wang et al.
Accumulating evidence indicates that many ATG (autophagy related) proteins perform non-canonical functions beyond their canonical roles in autophagy, particularly when they localize to subcellular compartments outside the cytoplasm. Althoug...