The TBCK-PPP1R21-FERRY3/C12orf4 complex: a RAB5-GAP brake essential for endo-lysosomal homeostasis [0.03%]
TBCK-PPP1R21-FERRY3/C12orf4复合体：维持内溶酶体稳态的RAB5-GAP制动因子
Yingji Chen,Xiayun Xu,Yi Zheng et al.
Yingji Chen et al.
TBCK syndrome is a severe neurodevelopmental disorder characterized by hypotonia, intellectual disability, and progressive neurodegeneration. While the TBCK gene has been implicated in MTOR signaling, its primary molecular function has rema...
Autocrine SFRP2 (secreted frizzled related protein 2) enhances lung myofibroblast fibrogenic activity by suppressing PINK1-mediated mitophagy initiation [0.03%]
自分泌SFRP2通过抑制PINK1介导的线粒体自噬诱导增强肺肌成纤维细胞促纤维化活性
Yingying Lin,Tianxiang Lei,Yifan Jia et al.
Yingying Lin et al.
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease driven by persistent activation of pulmonary myofibroblasts, but the regulatory mechanisms sustaining this pathological state remain incompletely understood. Using sin...
α-hemolysin targets LGALS3 (galectin 3) to promote intracellular survival of Staphylococcus aureus via lysosomal disruption and autophagy inhibition [0.03%]
α-溶血素通过溶酶体破坏和自噬抑制将LGALS3（半乳糖凝集素3）定位于细胞内以促进金黄色葡萄球菌的胞内生存
Yanhao Zhang,Zhuo Zhao,Pu Han et al.
Yanhao Zhang et al.
Intracellular persistence caused by Staphylococcus aureus (S. aureus) is among the primary reasons for recurrence and difficulty in eradicating S. aureus infections. In this study, we identify the secreted protein Hla (α-hemolysin) by S. a...
Alice Viotti,Claudia Molinaro,Jessica Perego et al.
Alice Viotti et al.
Ischemic stroke is a severe medical condition characterized by diminished blood flow to the brain, resulting in a shortage of oxygen and nutrients. During ischemia, neurons surrounding the cerebral infarct initiate macroautophagy. However, ...
RETREG1/FAM134B-mediated ERGICphagy regulates GSDME-dependent dendritic cell pyroptosis during sepsis [0.03%]
RETREG1/FAM134B介导的ERGIC自噬调控脓毒症期间GSDME依赖性的树突细胞焦亡
Yu Duan,Peng-Yi He,Cheng-Long Zhu et al.
Yu Duan et al.
During the development of sepsis, aberrant dendritic cell (DC) pyroptosis results in a significant decrease in the numbers of DCs and immune dysfunction. However, the molecular mechanisms regulating DC pyroptosis in sepsis remain unclear. E...
Chaperone-mediated autophagy: the Achilles heel of the retinal pigment epithelium during age-related macular degeneration [0.03%]
年龄相关性黄斑变性时视网膜色素上皮细胞中分子伴侣介导的自噬是其薄弱环节
Juan Ignacio Jiménez-Loygorri,Ana Maria Cuervo,Deborah A Ferrington et al.
Juan Ignacio Jiménez-Loygorri et al.
Chaperone-mediated autophagy (CMA) is a selective autophagy pathway that targets specific proteins containing a KFERQ-like motif for lysosomal degradation. It has been shown by us and others that CMA decreases during physiological aging in ...
SLC29A1/ENT1 and SLC29A3/ENT3 differentially regulate autophagy [0.03%]
SLC29A1/ENT1和SLC29A3/ENT3差异调节自噬
Bhawana Bissa,Tejinder Kaur,Arnav Joshi et al.
Bhawana Bissa et al.
Despite the well-established role of equilibrative nucleoside transporters (ENTs) in salvaging nucleosides for DNA synthesis, the presence of multiple ENT subfamilies within a single genome suggests putative, non-redundant functions in main...
STING1 exacerbates iodinated contrast-induced acute kidney injury by promoting ferroptosis through chaperone-mediated autophagic degradation of FTH1 [0.03%]
STING1通过促进自噬降解FTH1来加剧碘对比剂引起的急性肾损伤及铁死亡
Ting Wu,Xi Wu,Juan Cai et al.
Ting Wu et al.
Iodinated contrast-induced acute kidney injury (CI-AKI) is a common clinical complication with poor prognostic outcomes, yet its molecular mechanisms remain incompletely understood. Ferroptosis, a regulated form of cell death driven by iron...
Control of phagophore membrane expansion: Atg8-Atg1 as the master switch [0.03%]
吞噬泡膜扩增的调控：Atg8-Atg1作为主开关
Yi-He Feng,Jing Zhu,Yu Ding et al.
Yi-He Feng et al.
Autophagosome formation is catalyzed by multiple branches of Atg protein machineries, calling for the existence of a master regulator to coordinate their distinct activities. A prime candidate of such a regulator is Atg8. This protein has a...
Omid Vakili,Daniel J Klionsky,Russel J Reiter et al.
Omid Vakili et al.
Autophagy, a conserved lysosomal degradation pathway, is increasingly recognized as a central regulator of metabolic health. Its impairment contributes directly to obesity and type 2 diabetes by disrupting nutrient sensing, stress adaptatio...