Deubiquitinase USP15 restricts LC3-dependent targeting of Mycobacterium tuberculosis [0.03%]
脱泛素酶USP15限制结核分枝杆菌的LC3依赖性靶向作用
Kathryn C Rahlwes,Priscila C Campos,Beatriz R S Dias et al.
Kathryn C Rahlwes et al.
Macroautophagy/autophagy enables macrophages to degrade intracellular Mycobacterium tuberculosis (Mtb), and this defense depends on E3 ubiquitin ligases such as PRKN/PARKIN/PARK2 and SMURF1, which tag Mtb-associated structures for lysosomal...
Mitophagic activity and protein levels differ across and within muscles: implications for future skeletal muscle mitophagy research [0.03%]
线粒体自噬活性和蛋白质水平在肌肉间和肌内存在差异：对未来骨骼肌线粒体自噬研究的影响
Fasih A Rahman,Mackenzie Q Graham,Joe Quadrilatero
Fasih A Rahman
Skeletal muscle is a heterogeneous tissue consisting of fibers with distinct contractile speeds, metabolic profiles, and cellular signaling. This heterogeneity may extend to mitochondrial quality control processes such as mitophagy. Using m...
SNX16 functions as a nutrient-sensitive regulator of autophagosomal components recycling [0.03%]
SNX16作为营养敏感的自噬溶酶体循环调节因子参与自噬流
Yueguang Que,Huilin Rong
Yueguang Que
In macroautophagy/autophagy, the inner membrane of the autophagosome and its contents are degraded within the autolysosome, while outer membrane proteins are recycled via a process known as autophagosomal components recycling (ACR). ACR is ...
Correction [0.03%]
改正
Published Erratum
Autophagy. 2026 Jan 24:1. DOI:10.1080/15548627.2026.2622231 2026
Daolin Tang,Rui Kang,Daniel J Klionsky
Daolin Tang
A recent study published in Nature by Zhang et al. reported that cytosolic acetyl-CoA functions as a signaling metabolite that regulates NLRX1-dependent mitophagy during nutrient stress. This discovery reveals a metabolic checkpoint for mit...
Jianshuang Li,Wenjun Wang,Li He et al.
Jianshuang Li et al.
Mitochondria maintain homeostasis through dynamic remodeling and stress-responsive pathways, including the formation of specialized subdomains. Peripheral mitochondrial fission generates small MTFP1-enriched mitochondria (SMEM), which encap...
Lactucopicrin promotes the autophagic degradation of MAP2K4/MKK4 by mediating CCDC50 palmitoylation to alleviate osteoarthritis progression [0.03%]
莴苣苦脂素通过介导CCDC50棕榈酰化促进MAP2K4/MKK4的自噬降解以缓解骨关节炎进展
Wenjun Li,Qijie Sun,Konghe Hu et al.
Wenjun Li et al.
Macroautophagy/autophagy plays a crucial role in maintaining cellular homeostasis and protecting against osteoarthritis (OA). Its dysregulation contributes to OA progression by promoting chondrocyte senescence, inflammation, and cartilage d...
Molecular engineering of lysosome-based degraders unveils a rapidly expanding therapeutic strategy [0.03%]
基于溶酶体的降解剂分子工程技术揭示了一种迅速扩展的治疗策略
Adele Rivault,Jade Dussart-Gautheret,Rachid Benhida et al.
Adele Rivault et al.
The targeted degradation of oncogenic or misfolded proteins has emerged as a promising therapeutic strategy. While proteolysistargeting chimeras (PROTACs) and related technologies have successfully hijacked the ubiquitin-proteasome system t...
The PI4K2A-OSBPL6/ORP6-PS axis mediates lysosomal membrane repair to restore neuronal lipid homeostasis and promote neuronal survival after spinal cord injury [0.03%]
PI4K2A-OSBPL6/ORP6-PS轴介导溶酶体膜修复，恢复神经元脂质稳态并促进脊髓损伤后的神经元存活
Haojie Zhang,Yu Kang,Tianlun Zhao et al.
Haojie Zhang et al.
Dysfunction of the neuronal macroautophagy/autophagy-lysosome system is a critical contributor to neuronal death following spinal cord injury (SCI), but the underlying mechanisms remain elusive. Our study demonstrated that SCI induced impai...
Apoptotic bodies derived from human umbilical cord mesenchymal stem cells improve recovery from myocardial infarction in swine [0.03%]
人脐带间充质干细胞凋亡体改善猪心脏梗死后的恢复效果
Wei Luo,Hao Li,Pengfei Zhang et al.
Wei Luo et al.
Apoptotic bodies (ABs) are a type of extracellular vesicles (EVs) that could contribute to the paracrine effect of stem cells. However, their potential in treating cardiovascular diseases is largely unexplored. This study investigated the t...