Autophagic perturbation caused by reduced lysosomal activity positively regulates cell competition [0.03%]
由溶酶体活性降低引起的自噬扰动可正向调节细胞竞争
Eilma Akter,Shunsuke Kon
Eilma Akter
Newly emerging transformed epithelial cells are recognized and apically removed by surrounding normal cells through a biological event termed "cell competition". However, little is known about the mechanisms underlying this process. In a re...
Defects in PINK-PRKN-PARK7/DJ-1-dependent mitophagy and autosomal recessive Parkinson disease [0.03%]
与PINK-PRKN-PARK7/DJ-1依赖的线粒体自噬缺陷相关的常染色体隐性帕金森病
Dorien Imberechts,Wim Vandenberghe
Dorien Imberechts
PINK1-PRKN mediated mitophagy: differences between in vitro and in vivo models [0.03%]
基于体外和体内模型的PINK1-PRKN介导的线粒体自噬的区别
Rui Han,Yanting Liu,Shihua Li et al.
Rui Han et al.
Mitophagy is a key intracellular process that selectively removes damaged mitochondria to prevent their accumulation that can cause neuronal degeneration. During mitophagy, PINK1 (PTEN induced kinase 1), a serine/threonine kinase, works wit...
Eructophagy: macrophages use autophagic machinery to burp out parts of their meal [0.03%]
打嗝型自噬：巨噬细胞利用自噬机制将其部分餐点打嗝而出
Jenny A Nguyen,Catherine J Greene,Robin M Yates
Jenny A Nguyen
The phagolysosome is an antimicrobial and degradative organelle that plays key roles in macrophage-mediated inflammatory and homeostatic functions. Whereas mature phagolysosomes are known to sequester and degrade their contents into basic n...
Yuqing Lei,Ting Huang,Gaoyue Jiang et al.
Yuqing Lei et al.
Macroautophagy/autophagy is a catabolic recycling pathway and is tightly regulated by upstream signals. Autophagy genes are quickly upregulated upon stimuli such as nutrition limitation in response to the external environment. However, how ...
Yaiza R Varela,Alicia Alonso
Yaiza R Varela
LC3/GABARAP constitute a macroautophagy/autophagy-related protein family derived from yeast Atg8. The involvement of specific lipids in LC3/GABARAP function is poorly understood. Exploring the interaction of LC3/GABARAP proteins with phosph...
Development of new tools to study membrane-anchored mammalian Atg8 proteins [0.03%]
研究锚定在膜上的哺乳动物Atg8蛋白的新工具开发
Sang-Won Park,Pureum Jeon,Akinori Yamasaki et al.
Sang-Won Park et al.
A:C autophagic membrane:cytosol; ALS amyotrophic lateral sclerosis; ATG4 autophagy related 4; Atg8 autophagy related 8; BafA1 bafilomycin A1; BNIP3L/Nix BCL2 interacting protein 3 like; CALCOCO2/NDP52 calcium binding and coiled-coil domain ...
Correction [0.03%]
改正
Published Erratum
Autophagy. 2022 Oct 12:1-2. DOI:10.1080/15548627.2022.2122346 2022
Impaired TFEB activation and mitophagy as a cause of PPP3/calcineurin inhibitor-induced pancreatic β-cell dysfunction [0.03%]
PPARA基因变异通过抑制TFEB活化和线粒体自噬导致胰岛β细胞功能障碍
Kihyoun Park,Seong Keun Sonn,Seungwoon Seo et al.
Kihyoun Park et al.
Macroautophagy/autophagy or mitophagy plays crucial roles in the maintenance of pancreatic β-cell function. PPP3/calcineurin can modulate the activity of TFEB, a master regulator of lysosomal biogenesis and autophagy gene expression, throu...
Phosphatidylinositol-4-phosphate joins the dance of plant autophagosome formation [0.03%]
磷脂酰肌醇-4-磷酸参与植物自噬体形成的舞动
Rodrigo Enrique Gomez,Julie Castets,Josselin Lupette et al.
Rodrigo Enrique Gomez et al.
In plants, macroautophagy/autophagy is a key mechanism that contributes to their ability to cope with a wide range of environmental constraints such as drought, nutrient starvation or pathogen resistance. Nevertheless, the molecular mechani...