--Atg9 interactions via its transmembrane domains are required for phagophore expansion during autophagy [0.03%]
自噬过程中自体吞噬小泡的延伸需要Atg9通过其跨膜区进行交互作用
Sabrina Chumpen Ramirez,Rubén Gómez-Sánchez,Pauline Verlhac et al.
Sabrina Chumpen Ramirez et al.
During macroautophagy/autophagy, precursor cisterna known as phagophores expand and sequester portions of the cytoplasm and/or organelles, and subsequently close resulting in double-membrane transport vesicles called autophagosomes. Autopha...
Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy [0.03%]
α疱疹病毒被膜蛋白UL21通过TOLLIP介导的选择性自噬促进CGAS降解从而抑制天然免疫
Zicheng Ma,Juan Bai,Chenlong Jiang et al.
Zicheng Ma et al.
Alpha-herpesvirus causes lifelong infections and serious diseases in a wide range of hosts and has developed multiple strategies to counteract the host defense. Here, we demonstrate that the tegument protein UL21 (unique long region 21) in ...
Wayne D Hawkins,Emily R Grush,Daniel J Klionsky
Wayne D Hawkins
Macroautophagy/autophagy is the process by which portions of the cytoplasm are sequestered within a transient compartment and delivered to the degradative organelle of the cell, the vacuole or lysosome. Autophagy is a fundamental cytoprotec...
Transient systemic autophagy ablation irreversibly inhibits lung tumor cell metabolism and promotes T-cell mediated tumor killing [0.03%]
瞬时消融系统性自噬会不可逆地抑制肺肿瘤细胞的代谢并促进T细胞介导的肿瘤杀伤作用
Kyle Nunn,Jessie Yanxiang Guo
Kyle Nunn
Macroautophagy/autophagy is a highly conserved catabolic process pivotal to cellular homeostasis and support of tumorigenesis. Being a potential therapeutic target for cancer, we have worked to understand the implications of autophagy inhib...
The telomeric protein TERF2/TRF2 impairs HMGB1-driven autophagy [0.03%]
端粒蛋白TERF2/TRF2抑制HMGB1驱动的自噬反应
Sara Iachettini,Fabio Ciccarone,Carmen Maresca et al.
Sara Iachettini et al.
TERF2/TRF2 is a pleiotropic telomeric protein that plays a crucial role in tumor formation and progression through several telomere-dependent and -independent mechanisms. Here, we uncovered a novel function for this protein in regulating th...
An inducible expression system for the manipulation of autophagic flux in vivo [0.03%]
一种用于在活体内操纵自噬通量的诱导表达系统
Lars Schlotawa,Ana Lopez,Gentzane Sanchez-Elexpuru et al.
Lars Schlotawa et al.
Much of our understanding of the intracellular regulation of macroautophagy/autophagy comes from in vitro studies. However, there remains a paucity of knowledge about how this process is regulated within different tissues during development...
A/(H1N1) pdm09 NS1 promotes viral replication by enhancing autophagy through hijacking the IAV negative regulatory factor LRPPRC [0.03%]
甲型(H1N1)流感病毒NS1通过劫持IAV负调控因子LRPPRC促进自噬从而增强病毒感染力
Xing Guo,Zhenyu Zhang,Chaohui Lin et al.
Xing Guo et al.
The quadrilateral reassortant IAV A/(H1N1) pdm09 is the pathogen responsible for the first influenza pandemic of the 21st century. The virus spread rapidly among hosts causing high mortality within human population. Efficient accumulation o...
PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805 [0.03%]
PTP4A2通过去磷酸化VCP/p97的Tyr805残基促进lysophagy
Yunpeng Bai,Guimei Yu,Hong-Ming Zhou et al.
Yunpeng Bai et al.
Overexpression of PTP4A phosphatases are associated with advanced cancers, but their biological functions are far from fully understood due to limited knowledge about their physiological substrates. VCP is implicated in lysophagy via collab...
Ablation of endothelial Atg7 inhibits ischemia-induced angiogenesis by upregulating Stat1 that suppresses Hif1a expression [0.03%]
内皮细胞Atg7缺失通过上调Stat1抑制Hif1a表达从而抑制缺血诱导的血管生成
Hongmin Yao,Jian Li,Zhixue Liu et al.
Hongmin Yao et al.
Ischemia-induced angiogenesis is critical for blood flow restoration and tissue regeneration, but the underlying molecular mechanism is not fully understood. ATG7 (autophagy related 7) is essential for classical degradative macroautophagy/a...
LC3-dependent EV loading and secretion (LDELS) promotes TFRC (transferrin receptor) secretion via extracellular vesicles [0.03%]
LC3依赖的EV装载和分泌(LDELS)通过细胞外囊泡促进TFRC(转铁蛋白受体)的分泌
Jackson O Gardner,Andrew M Leidal,Tan A Nguyen et al.
Jackson O Gardner et al.
LC3-dependent EV loading and secretion (LDELS) is a secretory autophagy pathway in which the macroautophagy/autophagy machinery facilitates the packaging of cytosolic cargos, such as RNA-binding proteins, into extracellular vesicles (EVs) f...