Eating while intoxicated: characterizing the molecular mechanism behind V. cholerae toxin MakA-regulated autophagy [0.03%]
醉酒进食：霍乱弧菌毒素MakA调节的自噬分子机制特征分析
Dale P Corkery,Yao-Wen Wu
Dale P Corkery
Extracellular pathogens utilize secreted virulence factors to regulate host cell function. Recently we characterized the molecular mechanism behind host macroautophagy/autophagy regulation by the Vibrio cholerae toxin MakA. Cholesterol bind...
Randini Nanayakkara,Rajendra Gurung,Samuel J Rodgers et al.
Randini Nanayakkara et al.
Lysosomes are the primary degradative compartment within cells and there have been significant advances over the past decade toward understanding how lysosome homeostasis is maintained. Lysosome repopulation ensures sustained autophagy func...
Regulation of RB1CC1/FIP200 stability and autophagy function by CREBBP-mediated acetylation in an intrinsically disordered region [0.03%]
CREBBP介导的内在无序区乙酰化对RB1CC1/FIP200稳定性及其自噬功能的调控
Fei Yi,Chunmiao Cai,Banzhan Ruan et al.
Fei Yi et al.
RB1CC1/FIP200 is an essential macroautophagy/autophagy protein that plays an important role in a variety of biological and disease processes through its canonical autophagy-dependent and -independent functions. However, it remains largely u...
J Luke Postoak,Wenqiang Song,Lan Wu et al.
J Luke Postoak et al.
The development of a broad repertoire of T cells in the immune system requires interaction of T cell receptors expressed by immature T cells with peptide/major histocompatibility complexes (MHCs) displayed by specialized epithelial cells in...
Membrane Atg8ylation, stress granule formation, and MTOR regulation during lysosomal damage [0.03%]
溶酶体损伤期间的膜Atg8ylation，应激颗粒形成和MTOR调节
Jingyue Jia,Fulong Wang,Zambarlal Bhujabal et al.
Jingyue Jia et al.
The functions of mammalian Atg8 proteins (mATG8s) expand beyond canonical autophagy and include processes collectively referred to as Atg8ylation. Global modulation of protein synthesis under stress conditions is governed by MTOR and liquid...
MCOLN3/TRPML3 bridges the regulation of autophagosome biogenesis by PtdIns3P and the calcium channel [0.03%]
MCOLN3/TRPML3连接由PtdIns3P和钙通道调节的自噬体生物发生过程
Yuchen Lei,Daniel J Klionsky
Yuchen Lei
In recent years, an increasing number of studies have started to investigate the roles of ions and ion channels in macroautophagy/autophagy. One finding is that calcium regulates multiple stages of autophagy with lysosomal calcium release b...
WeiChao Hao,MeiJuan Dian,JiaHong Wang et al.
WeiChao Hao et al.
Mcroautophagy/autophagy plays an important role in maintaining homeostasis during nutrient starvation. However, whether epitranscriptomic events are involved in this process remains unclear. Our recent findings suggest that m6A reader YTHDF...
Daniel J Klionsky
Daniel J Klionsky
Over the past several years, I have been interacting with an increasing number of Iranian scientists, including those currently living in Iran as well as others who are being educated elsewhere or have independent positions outside of that ...
Keisuke Tabata,Marika Saeki,Tamotsu Yoshimori et al.
Keisuke Tabata et al.
Macroautophagy (hereafter autophagy) is a highly conserved intracellular degradation system to maintain cellular homeostasis by degrading cellular components such as misfolded proteins, nonfunctional organelles, pathogens, and cytosol. Conv...
Lysosomal dysfunction, autophagic defects, and CLN5 accumulation underlie the pathogenesis of KCTD7-mutated neuronal ceroid lipofuscinoses [0.03%]
溶酶体功能障碍，自噬缺陷以及CLN5蛋白的累积是KCTD7突变神经元蜡样脂褐质蓄积症的发病机制
Yalan Wang,Hongyan Wang,Chenji Wang
Yalan Wang
Lysosomes are essential catabolic organelles responsible for the degradation of biomacromolecules into low-molecular-weight materials for subsequent reuse. Neuronal ceroid lipofuscinoses (NCLs) are a group of fatal neurodegenerative lysosom...