The COPS3-FOXO3 positive feedback loop regulates autophagy to promote cisplatin resistance in osteosarcoma [0.03%]
COPS3-FOXO3正反馈环通过调节自噬促进骨肉瘤的顺铂耐药性
Jianfang Niu,Taiqiang Yan,Wei Guo et al.
Jianfang Niu et al.
Chemotherapy is an important treatment modality for osteosarcoma (OS), but the development of chemoresistance limits the therapeutic efficacy of OS and results in a poor prognosis. Thus, a better understanding of the mechanisms underlying c...
The Valsa Mali effector Vm1G-1794 protects the aggregated MdEF-Tu from autophagic degradation to promote infection in apple [0.03%]
Valsa mali效应子Vm1G-1794保护聚集的MdEF-Tu免受自噬降解以促进苹果感染
Runmin Che,Changhai Liu,Qi Wang et al.
Runmin Che et al.
Macroautophagy/autophagy is a conserved degradation pathway in eukaryotes that is required for recycling unwanted intracellular components, maintaining homeostasis, and coping with biotic and abiotic stresses. Pathogens have evolved to subv...
Lingna Xu,Liquan Wang,Chao Tong
Lingna Xu
Miga is an evolutionarily conserved protein that localizes to the outer membrane of mitochondria and mediates endoplasmic reticulum (ER)-mitochondrial contacts through interaction with VAP proteins in the ER. We recently reported that Miga ...
Gabriela Sarango,Bénédicte Manoury,Arnaud Moris
Gabriela Sarango
Sidi Zhang,Noboru Mizushima
Sidi Zhang
In this issue, we answer a frequently asked question regarding the evolution of the macroautophagy/autophagy pathway. Keywords:...
Extracellular SQSTM1 exacerbates acute pancreatitis by activating autophagy-dependent ferroptosis [0.03%]
细胞外SQSTM1通过激活自噬依赖性铁死亡加重急性胰腺炎
Liangchun Yang,Fanghua Ye,Jiao Liu et al.
Liangchun Yang et al.
5-HETE, 5-hydroxyeicosatetraenoic acid; ACSL4, acyl-CoA synthetase long chain family member 4; AP, acute pancreatitis; ATG, autophagy related; AGER, advanced glycosylation end-product specific receptor; DAMPs, danger/damage-associated molec...
TraB, a novel plant ER-mitochondrial contact site protein functions as a mitophagy receptor in plants [0.03%]
TraB是一种新的植物内质网-线粒体接触蛋白，在植物中作为线粒体自噬受体发挥作用
Patrick Duckney,Chengyang Li,Patrick J Hussey et al.
Patrick Duckney et al.
Autophagic degradation of mitochondria (known as mitophagy) is known to occur in all eukaryotes, and is important for the turnover of damaged mitochondria and recycling of nutrients during starvation. Targeting of mitochondria for autophagi...
Daniel Schmitt,Süleyman Bozkurt,Pascale Henning-Domres et al.
Daniel Schmitt et al.
Autophagosome isolation enables the thorough investigation of structural components and engulfed materials. Recently, we introduced a novel antibody-based FACS-mediated method for isolation of native macroautophagic/autophagic vesicles and ...
VDAC1 balances mitophagy and apoptosis in leafhopper upon arbovirus infection [0.03%]
病毒侵染介壳虫时VDAC1在线粒体自噬和细胞凋亡之间的平衡作用
Qian Chen,Dongsheng Jia,Jiping Ren et al.
Qian Chen et al.
Mitophagy is a form of autophagy that selectively removes damaged mitochondria and attenuates mitochondrial-dependent apoptosis during viral infection, but how arboviruses balance mitophagy and apoptosis to facilitate persistent viral infec...
Defensosomes: a new role for autophagy proteins in innate immune defense [0.03%]
防御体：自噬蛋白在先天免疫防御中的新作用
Krystal L Ching,Victor J Torres,Ken Cadwell
Krystal L Ching
In recent years, the contribution of exosomes to immunity, inflammation and host-pathogen interaction have been appreciated. Exosomes are small secreted extracellular vesicles from endosomal origin that contain a myriad of cellular molecule...