Mei Luo,Leng Han
Mei Luo
Resistance to anti-cancer therapy is a major challenge for cancer treatment. Many studies revealed that macroautophagy/autophagy inhibition can overcome autophagy-mediated therapy resistance, but these efforts have not yet led to the succes...
TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection [0.03%]
TRIM7/RNF90通过调节ATG7泛素化促进李斯特菌感染期间的自噬过程
Jie Wang,Xiao Qin,Yulu Huang et al.
Jie Wang et al.
L. monocytogenes is a widely used infection model for the research on pathogenesis and host defense against gram-positive intracellular bacteria. Emerging evidence indicates that posttranslational modifications play a critical role in the r...
Léa P Wilhelm,Ian G Ganley
Léa P Wilhelm
Mitochondria, often called "the powerhouse" of the cell due to their role as the main energy supplier, regulate numerous complex processes including intracellular calcium homeostasis, reactive oxygen species (ROS) production, regulation of ...
Suresh Kumar,Ruheena Javed,Masroor A Paddar et al.
Suresh Kumar et al.
The precursors to mammalian autophagosomes originate from preexisting membranes contributed by a number of sources, and subsequently enlarge through intermembrane lipid transfer, then close to sequester the cargo, and merge with lysosomes t...
PEX13 prevents pexophagy by regulating ubiquitinated PEX5 and peroxisomal ROS [0.03%]
PEX13通过调节泛素化PEX5和过氧化物酶体ROS来防止pexophagy
Nicholas D Demers,Victoria Riccio,Doo Sin Jo et al.
Nicholas D Demers et al.
Peroxisomes are rapidly degraded during amino acid and oxygen deprivation by a type of selective autophagy called pexophagy. However, how damaged peroxisomes are detected and removed from the cell is poorly understood. Recent studies sugges...
Ji Feng,Jing Zhou,Yong Wu et al.
Ji Feng et al.
Ischemia may be the most common pathological occurrence to restrict nutrient availability and induce macroautophagy/autophagy. As a self-digestive process, autophagy helps sustain nutrient/energy and restrict damages in short-term scenarios...
Autophagy inhibition signals through senescence to promote tumor suppression [0.03%]
自噬抑制通过衰老促进肿瘤抑制信号传导
Nanfang Peng,Helen H Kang,Yan Feng et al.
Nanfang Peng et al.
Macroautophagy/autophagy, a stress-responsive cellular survival mechanism, plays important and context-dependent roles in cancer, and its inhibition has been implicated as a promising cancer therapeutic approach. The detailed mechanisms und...
Selma Dahmane,Kasturika Shankar,Lars-Anders Carlson
Selma Dahmane
Viruses are masters at using cellular pathways to aid their replication. Cryo-electron tomography of poliovirus-infected cells revealed how it utilizes macroautophagy to its advantage. Assembly of these non-enveloped virions takes place dir...
Substitution of PINK1 Gly411 modulates substrate receptivity and turnover [0.03%]
PINK1 Gly411的替代调节底物受性和转换率
Fabienne C Fiesel,Dominika Fričová,Caleb S Hayes et al.
Fabienne C Fiesel et al.
The ubiquitin (Ub) kinase-ligase pair PINK1-PRKN mediates the degradation of damaged mitochondria by macroautophagy/autophagy (mitophagy). PINK1 surveils mitochondria and upon stress accumulates on the mitochondrial surface where it phospho...
Regulation of autophagosome biogenesis and mitochondrial bioenergetics by the cholesterol transport protein GRAMD1C [0.03%]
胆固醇转运蛋白GRAMD1C对自噬体生物生成和线粒体生物能量学的调节作用
Chara Charsou,Matthew Yoke Wui Ng,Anne Simonsen
Chara Charsou
Autophagosomes are crucial components of the cellular recycling machinery that form at endoplasmic reticulum (ER)-associated sites. As the autophagosome membrane is largely devoid of transmembrane proteins, autophagosome biogenesis is thoug...