YWHAE/14-3-3ε crotonylation regulates leucine deprivation-induced autophagy [0.03%]
YWHAE/14-3-3ε的肉桂酰化调控由leucine剥夺诱导的自噬过程
Zilong Zheng,Qing Zhong,Xianghua Yan
Zilong Zheng
Macroautophagy/autophagy is an important process responsible for protein turnover and cell survival in amino acid-deprived conditions, especially for leucine (Leu). With the dramatic advances in mass spectrometry, many new post-translationa...
Hagai Abeliovich,Jayanta Debnath,Wen-Xing Ding et al.
Hagai Abeliovich et al.
In this editors' corner, the section editors were asked to indicate where they see the autophagy field heading and to suggest what they consider to be key unanswered questions in their specialty area. ...
Sensitive imaging of Endoplasmic reticulum (ER) autophagy with an acidity-reporting ER-Tracker [0.03%]
酸性报告内质网荧光探针在自噬中敏感的成像内质网(endoplasmic reticulum, ER)
Yilong Shi,Xiaoxue Zou,Xianghui Zheng et al.
Yilong Shi et al.
Macroautophagic/autophagic turnover of endoplasmic reticulum (reticulophagy) is critical for cell health. Herein we reported a sensitive fluorescence-on imaging of reticulophagy using a small molecule probe (ER-proRed) comprised of green-em...
Qian Xue,Ding Yan,Xi Chen et al.
Qian Xue et al.
Ferroptosis is a type of iron-dependent regulated cell death characterized by unrestricted lipid peroxidation and membrane damage. Although GPX4 (glutathione peroxidase 4) plays a master role in blocking ferroptosis by eliminating phospholi...
Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy [0.03%]
中风时小神经胶质细胞的吞噬功能障碍由能量耗竭和自噬诱导引起
Sol Beccari,Virginia Sierra-Torre,Jorge Valero et al.
Sol Beccari et al.
Microglial phagocytosis of apoptotic debris prevents buildup damage of neighbor neurons and inflammatory responses. Whereas microglia are very competent phagocytes under physiological conditions, we report their dysfunction in mouse and pre...
The chaperone-assisted selective autophagy complex dynamics and dysfunctions [0.03%]
伴蛋白介导的选择性自噬复合体的动态变化和功能障碍
Barbara Tedesco,Leen Vendredy,Vincent Timmerman et al.
Barbara Tedesco et al.
Each protein must be synthesized with the correct amino acid sequence, folded into its native structure, and transported to a relevant subcellular location and protein complex. If any of these steps fail, the cell has the capacity to break ...
The nucleoprotein of influenza A virus inhibits the innate immune response by inducing mitophagy [0.03%]
甲型流感病毒的核蛋白通过诱导线粒自噬来抑制先天免疫反应
Bo Zhang,Shuai Xu,Minxuan Liu et al.
Bo Zhang et al.
Mitophagy is a form of autophagy that plays a key role in maintaining the homeostasis of functional mitochondria in the cell. Viruses have evolved various strategies to manipulate mitophagy to escape host immune responses and promote virus ...
Endothelial TFEB signaling-mediated autophagic disturbance initiates microglial activation and cognitive dysfunction [0.03%]
内皮TFEB信号介导的自噬紊乱启动小胶质细胞激活和认知功能障碍
Yaping Lu,Xiang Chen,Xiuxiu Liu et al.
Yaping Lu et al.
Cognitive impairment caused by systemic chemotherapy is a critical question that perplexes the effective implementation of clinical treatment, but related molecular events are poorly understood. Herein, we show that bortezomib exposure lead...
DBI/ACBP is a targetable autophagy checkpoint involved in aging and cardiovascular disease [0.03%]
DBI/ACBP是与衰老和心血管疾病相关的可靶向自噬检点蛋白
Léa Montégut,Adrien Joseph,Hui Chen et al.
Léa Montégut et al.
DBI/ACBP (diazepam binding inhibitor, acyl-CoA binding protein) is a phylogenetically conserved paracrine inhibitor of macroautophagy/autophagy. As such, DBI/ACBP acts as a pro-aging molecule. Indeed, we observed that the knockout of ACB1 (...
AutophagosOMES: identification of autophagosomal cargo in CD4+ T cells by proteomics [0.03%]
自噬体组分：通过蛋白质组学识别CD4+ T细胞中的自噬体货物蛋白
Faris Jafri,Megan Moore,Shree Padma Metur et al.
Faris Jafri et al.
Macroautophagy/autophagy, a cellular process that sequesters and breaks down cellular components in the lysosome/vacuole, is important in various events where cell composition undergoes changes. Broadly, autophagy is involved in T cell regu...