Endosomal-dependent mitophagy coordinates mitochondrial nucleoid and mtDNA elimination [0.03%]
内体依赖的线粒体自噬协调了线粒体核区和mtDNA的消除
Ayesha Sen,Julia Boix,David Pla-Martín
Ayesha Sen
Mitophagy and its variants are considered important salvage pathways to remove dysfunctional mitochondria. Non-canonical mitophagy, independent of autophagosome formation and including endosomal-dependent mitophagy, operate upon specific in...
Effects of STAU1/staufen1 on autophagy in neurodegenerative diseases [0.03%]
STAU1/staufen1对神经退行性疾病中自噬的影响
Stefan M Pulst,Daniel R Scoles,Sharan Paul
Stefan M Pulst
The double-stranded RNA-binding protein, STAU1 (staufen double-stranded RNA binding protein 1) is a multifunctional protein that localizes to stress granules (SGs). We had previously found that STAU1 is overabundant in fibroblast cell lines...
Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes [0.03%]
小胶质细胞和巨噬细胞中自噬的抑制加剧了先天免疫反应并恶化了脑损伤的结果
Nivedita Hegdekar,Chinmoy Sarkar,Sabrina Bustos et al.
Nivedita Hegdekar et al.
Excessive and prolonged neuroinflammation following traumatic brain injury (TBI) contributes to long-term tissue damage and poor functional outcomes. However, the mechanisms contributing to exacerbated inflammatory responses after brain inj...
Kirti Lathoria,Pruthvi Gowda,Sonia B Umdor et al.
Kirti Lathoria et al.
Mutations in the Krebs cycle enzyme IDH1 (isocitrate dehydrogenase (NADP(+)) 1) are associated with better prognosis in gliomas. Though IDH1 mutant (IDH1R132H) tumors are characterized by their antiproliferative signatures maintained throug...
LYSET/TMEM251- a novel key component of the mannose 6-phosphate pathway [0.03%]
LYSET/TMEM251 - 曼诺糖-6-磷酸途径的关键新组分
Wenjie Qiao,Christopher M Richards,Sabrina Jabs
Wenjie Qiao
Degradation of macromolecules delivered to lysosomes by processes such as autophagy or endocytosis is crucial for cellular function. Lysosomes require more than 60 soluble hydrolases in order to catabolize such macromolecules. These soluble...
TTR (transthyretin) leads the autophagy disaster relief team against TARDBP/TDP-43 proteinopathy [0.03%]
转甲状腺素蛋白(TTR)带领自噬救灾队对抗TARDBP/TDP-43蛋白质病变
Yuan-Ping Chu,Pei-Chuan Ho,Kuen-Jer Tsai
Yuan-Ping Chu
TTR (transthyretin) strikes a neuroprotective function in the prevention of amyloid-β (Aβ) deposition in Alzheimer disease (AD). Perturbation of the stringently controlled TARDBP/TDP-43 (TAR DNA binding protein) expression gives rise to c...
LYSET/TMEM251/GCAF is critical for autophagy and lysosomal function by regulating the mannose-6-phosphate (M6P) pathway [0.03%]
LYSET/TMEM251/GCAF通过调节甘露糖-6-磷酸(M6P)途径对自噬和溶酶体功能至关重要
Bokai Zhang,Xi Yang,Ming Li
Bokai Zhang
Vertebrate cells rely on mannose-6-phosphate (M6P) modifications to deliver most lumenal hydrolases to the lysosome. As a critical trafficking signal for lysosomal enzymes, the M6P biosynthetic pathway has been thoroughly investigated. Howe...
Wenqiang Song,J Luke Postoak,Lan Wu et al.
Wenqiang Song et al.
Adipose tissue, or body fat, plays a critical role in the maintenance of health and the development of metabolic diseases. The pathological expansion of adipose tissue during obesity and the pathological reduction of adipose tissue during l...
The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc [0.03%]
线粒体自噬受体BNIP3对于椎间盘髓核细胞代谢稳态和线粒体功能的调节至关重要
Vedavathi Madhu,Miriam Hernandez-Meadows,Paige K Boneski et al.
Vedavathi Madhu et al.
The contribution of mitochondria to the metabolic function of hypoxic NP cells has been overlooked. We have shown that NP cells contain networked mitochondria and that mitochondrial translocation of BNIP3 mediates hypoxia-induced mitophagy....
Subhash Mehto,Soumya Kundu,Swati Chauhan et al.
Subhash Mehto et al.
The NOD1-NOD2-RIPK2-NFKB/NF-κB pro-inflammatory axis plays a significant role in regulating the immune response to bacterial infection. However, an excess of NFKB-dependent cytokine response can be detrimental and, thus, should be kept und...