A distinct linker mediating ER-autophagosome membrane contact site (EACS) in plants [0.03%]
植物中独特的连接子介导内质网-自噬体膜接触位点(EACS)
Hao Ye,Jiayang Gao,Liwen Jiang
Hao Ye
Endoplasmic reticulum (ER) membrane contacts play a central role in regulating autophagosome formation in yeast and mammals. However, a direct functional linkage between the ER and autophagosomes in plants remains elusive. We have recently ...
Rapamycin and Alzheimer disease: a hypothesis for the effective use of rapamycin for treatment of neurodegenerative disease [0.03%]
雷帕霉素和阿尔茨海默病：关于雷帕霉素有效治疗神经退行性疾病的假说
Julian M Carosi,Timothy J Sargeant
Julian M Carosi
In 2019 we summarized work relating to the potential use of rapamycin for treating Alzheimer disease (AD). We considered the commentary necessary because use of rapamycin in people with AD is a very real prospect and we wanted to present a ...
Modeling Huntington disease through microRNA-mediated neuronal reprogramming identifies age-associated autophagy dysfunction driving the onset of neurodegeneration [0.03%]
通过microRNA介导的神经元重编程建模亨廷顿病，识别出与年龄相关的自噬功能障碍驱动了神经退行性病变的发生
Young Mi Oh,Seong Won Lee,Andrew S Yoo
Young Mi Oh
Huntington disease (HD) is an inherited neurodegenerative disease with adult-onset clinical symptoms. However, the mechanism by which aging triggers the onset of neurodegeneration in HD patients remains unclear. Modeling the age-dependent p...
Lucia Sedlackova,Tetsushi Kataura,Sovan Sarkar et al.
Lucia Sedlackova et al.
Age-related human pathologies present with a multitude of molecular and metabolic phenotypes, which individually or synergistically contribute to tissue degeneration. However, current lack of understanding of the interdependence of these mo...
Autophagic structures revealed by cryo-electron tomography: new clues about autophagosome biogenesis [0.03%]
基于冷冻电镜断层成像技术观察到的自噬结构及对自噬体形成的启示
Hana Popelka,Daniel J Klionsky
Hana Popelka
Transitions from the early to late phagophore, which occur to engulf cytoplasmic material within an autophagosome for macroautophagic/autophagic degradation, involve dynamic ultrastructural changes that are not fully understood. A recent st...
Louis R Parham,Nicolette M Johnson,Christopher J Lengner et al.
Louis R Parham et al.
Understanding how macroautophagy/autophagy contributes to tissue homeostasis is essential for understanding organismal health. The intestinal epithelium is an ideal model to define mechanisms that regulate tissue homeostasis because it hous...
Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress [0.03%]
EIF2S1（真核翻译起始因子2亚基α）的磷酸化在内质网应激期间TFEB和TFE3的核转位中不可或缺
Thao Thi Dang,Mi-Jeong Kim,Yoon Young Lee et al.
Thao Thi Dang et al.
There are diverse links between macroautophagy/autophagy pathways and unfolded protein response (UPR) pathways under endoplasmic reticulum (ER) stress conditions to restore ER homeostasis. Phosphorylation of EIF2S1/eIF2α is an important me...
PRKN/parkin-mediated mitophagy is induced by the probiotics Saccharomyces boulardii and Lactococcus lactis [0.03%]
产 probiotics Saccharomyces boulardii 和 Lactococcus lactis 诱导的 PRKN/parkin介导的线粒体自噬
Peter John Hawrysh,Jinghua Gao,Stephanie Tan et al.
Peter John Hawrysh et al.
Mitochondrial impairment is a hallmark feature of neurodegenerative disorders, such as Parkinson disease, and PRKN/parkin-mediated mitophagy serves to remove unhealthy mitochondria from cells. Notably, probiotics are used to alleviate sever...
Blockage of autophagosome-lysosome fusion through SNAP29 O-GlcNAcylation promotes apoptosis via ROS production [0.03%]
通过SNAP29的O-GlcNA酰化阻断自噬体-溶酶体融合促进ROS介导的细胞凋亡
Francesca Romana Pellegrini,Sara De Martino,Giulia Fianco et al.
Francesca Romana Pellegrini et al.
Macroautophagy/autophagy has been shown to exert a dual role in cancer i.e., promoting cell survival or cell death depending on the cellular context and the cancer stage. Therefore, development of potent autophagy modulators, with a clear m...
Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules [0.03%]
应力颗粒稳态通过TRIM21介导的G3BP1泛素化和自噬依赖性消除应力颗粒进行调节
Cuiwei Yang,Zhangshun Wang,Yingjin Kang et al.
Cuiwei Yang et al.
Eukaryotic stress granules (SGs) are highly dynamic assemblies of untranslated mRNAs and proteins that form through liquid-liquid phase separation (LLPS) under cellular stress. SG formation and elimination process is a conserved cellular st...