Transthyretin abnormalities in amyotrophic lateral sclerosis: High molecular weight species in cerebrospinal fluid and stromal deposits in choroid plexus [0.03%]
肌萎缩侧索硬化中前蛋白转运异常：脑脊液中的高分子量物质和脉络丛基质沉积物
Mahlon Collins,Heather Kwapiszeski,Jiyan An et al.
Mahlon Collins et al.
Transthyretin (TTR) is a plasma and cerebrospinal fluid (CSF) protein involved in transporting thyroid hormone and retinol, with additional roles in the central nervous system (CNS). The tetrameric structure of TTR is essential for its func...
Quantification of Alzheimer disease neuropathology using tissue microarrays [0.03%]
用于组织芯片的阿尔茨海默病神经病理学量化
Hoang-Tuong Nguyen-Hao,Jie Liu,Mario Novelli et al.
Hoang-Tuong Nguyen-Hao et al.
Alzheimer's disease (AD) is characterized by the hallmark pathologies of β-amyloid plaques and neurofibrillary tangles (NFTs), which vary across brain regions and between affected individuals. As a rapid research method to quantify hallmar...
Identification of disease-associated molecular signatures in the Prp-TDP-43A315T mouse model of ALS: Toward preclinical biomarker development [0.03%]
ALS小鼠模型中疾病相关分子标志物的鉴定普罗帕酮-tdp-43a315t向临床生物标记物发展
Yara Al Ojaimi,Samira Osman,Hugo Alarcan et al.
Yara Al Ojaimi et al.
Identifying disease-related molecular signatures that can be used as biomarkers is critical for the development of preclinical therapies for amyotrophic lateral sclerosis (ALS). In this study, we focused on the Prp-TDP-43A315T transgenic mo...
Antemortem radiologic and histopathologic presentation of Marchiafava-Bignami disease [0.03%]
Marchiafava-Bignami病的术前放射学和组织病理学表现
Leyla Canbeldek,Raquel T Yokoda,Lakshmi S Kulumani Mahadevan et al.
Leyla Canbeldek et al.
Marchiafava-Bignami disease (MBD) is a rare disorder, characterized by demyelination and cystic necrosis of the corpus callosum; it is typically seen in the setting of chronic alcoholism but may also occur with severe malnutrition. Clinical...
Neuromuscular pathology and mitochondrial dysfunction in sorbitol dehydrogenase gene-related distal hereditary motor neuropathies [0.03%]
索特糖脱氢酶基因相关远端遗传性运动神经病的神经肌肉病理和线粒体功能异常
Zhenyu Li,Xujun Chu,Yize Li et al.
Zhenyu Li et al.
Biallelic variants in sorbitol dehydrogenase (SORD) have been reported to be a major cause of autosomal recessive distal hereditary motor neuropathy (dHMN). In this study, the clinical and pathological features of 10 patients with SORD gene...
Clinicopathological characterization of enteric glia in colorectal cancer: Insights from a population-based cohort [0.03%]
基于人群的队列研究中肠胶质细胞在结直肠癌中的临床病理特征分析
Meike S Thijssen,Maartje Massen,Jaleesa R M van der Meer et al.
Meike S Thijssen et al.
Enteric glia contribute to the regulation of mucosal homeostasis and intestinal immunity. Enteric glia dysfunction is linked to various gastrointestinal disorders. We aimed to characterize the phenotype of enteric glia in colorectal cancer ...
Abundant nigral neuronal cytoplasmic inclusions in multiple system atrophy with slowly progressive levodopa-responsive parkinsonism [0.03%]
多系统萎缩症伴缓慢进展的左旋多巴反应性帕金森病患者黑质神经元胞浆内包涵体丰富
Toshimasa Ikeda,Teppei Fujioka,Mari Yoshida et al.
Toshimasa Ikeda et al.
Temporal progression of axonal degeneration in the visual system in experimental autoimmune encephalomyelitis: Insights from high-resolution neuropathology [0.03%]
高分辨率神经病理学揭示的实验性自身免疫性脑脊髓炎中视觉系统轴突变性的时程变化
Chang Liu,Athanasios S Alexandris,Marjan Gharagozloo et al.
Chang Liu et al.
Multiple sclerosis (MS) is characterized by inflammation, demyelination, and axonal degeneration in the CNS, leading to progressive neurological disability is generally regarded as an autoimmune disorder. Visual impairment, a frequent sympt...
Expanding the differential diagnosis for dural-based spindle cell neoplasms: A report of a rare GLI1-altered mesenchymal tumor of the CNS [0.03%]
中枢神经系统罕见的GLI1变异肉瘤性肿瘤的诊断报告
Monica Ospina-Romero,Shaan M Raza,Komal Shah et al.
Monica Ospina-Romero et al.
FGFR1 fusions in genomically and epigenetically bona fide glioblastoma, IDH-wildtype [0.03%]
基因组和表观基因型均符合的胶质母细胞瘤中IDH野生型FGFR1融合基因
Riley H Lochner,Suzanne Z Powell,Kar-Ming Fung et al.
Riley H Lochner et al.